Prognostic significance of distal renal tubular acidosis in posterior urethral valve

Sharma, Raj Kumar; Sharma, Ajay; Kapoor, Rakesh; Gupta, Amit

doi:10.1007/s004670100590

Cited by 9 publications

(4 citation statements)

References 18 publications

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“…Written informed consent was obtained from the parents or legal guardians of the participants prior to enrolment, and assent was taken from the subjects. The study group selection was based on the reported high prevalence of idRTA in patients with PUV [15,16]. The exclusion criteria were chronic kidney disease (CKD) after the surgical intervention, an alternative etiology of short stature, follow-up time shorter than 1 year, or loss to follow-up.…”

Section: Methodsmentioning

confidence: 99%

Bicarbonate therapy improves growth in children with incomplete distal renal tubular acidosis

et al. 2009

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Incomplete distal renal tubular acidosis (idRTA) has recently been associated with osteoporosis and growth retardation, attributed to the mild persistent metabolic acidosis. We hypothesized a therapeutic benefit from bicarbonate therapy on growth parameters in children with idRTA. In a study group of 40 surgically treated patients with posterior urethral valve (PUV) and normal estimated glomerular filtration rate, we evaluated the change in height standard deviation scores (SDSs) while they were on bicarbonate therapy in the presence of idRTA and complete distal renal tubular acidosis (dRTA). Age- and gender-matched healthy subjects constituted the control group (n = 55). Incomplete dRTA was evaluated by ammonium chloride acidification. The baseline height SDS of -1.94 +/- 0.41 and -5.31 +/- 1.95 in the groups with idRTA and complete dRTA, respectively, were significantly lower than that of the controls. After a follow-up period of 24.7 +/- 8.3 months on sodium bicarbonate therapy, the idRTA patients had a 66% increase in height SDS compared with 26% and 3% increases in the patients with PUV with complete dRTA and without dRTA, respectively. At the end of follow-up, mean height SDS in the group with idRTA no longer remained significantly lower than that of the controls (P = 0.42). We concluded that bicarbonate therapy improves height SDS in idRTA. This issue needs further validation in larger studies.

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Section: Methodsmentioning

confidence: 99%

Bicarbonate therapy improves growth in children with incomplete distal renal tubular acidosis

et al. 2009

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“…Hypocitraturia can be idiopathic or can be a manifestation of systemic metabolic acidosis, hypokalemia[4041] or inflammatory bowel disease. Hypocitraturia is treated with potassium citrate supplementation.…”

Section: Metabolic Risk Factorsmentioning

confidence: 99%

Epidemiology of pediatric urolithiasis

Sharma¹,

Filler²

2010

Indian J Urol

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Pediatric urolithiasis has increased globally in the last few decades. There has been a change in the pattern of stone composition with an increase in the frequency of kidney stones and a decrease in bladder stones. The role of familial predisposition and environmental factors in pediatric urolithiasis is now better understood. Metabolic factors are more common in pediatric urolithiasis than in adult stone disease. This review updates on the epidemiology of pediatric urolithiasis with a focus on the changing trends in the stone disease, current spectrum of stone disease encountered in clinical practice, individual predisposition and the role of environmental factors in stone formation.

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“…Unilateral ureter obstruction (UUO) and other forms of obstructive renal disease lead to tubular remodeling and may be associated in some forms with transient or persistent forms of renal tubular acidosis, mostly distal renal tubular acidosis [63,64]. In a rat model of adult bilateral ureter obstruction (for 24 hrs), a strong decrease in the expression of some acid-base transporting protein such as NHE3 or NBCn1 was documented.…”

Section: Regulation Of Pendrin In Disease Modelsmentioning

confidence: 99%

The Anion Exchanger Pendrin (SLC26A4) and Renal Acid-base Homeostasis

Wagner

Mohebbi

Capasso

et al. 2011

Cell Physiol Biochem

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The anion exchanger pendrin (Pds, SLC26A4) transports various anions including bicarbonate, chloride and iodide. In the kidney, pendrin is exclusively expressed on the luminal pole of bicarbonate-secretory type B intercalated cells. Genetic ablation of pendrin in mice abolishes luminal chloride-bicarbonate exchanger activity from type B intercalated cells suggesting that pendrin is the apical bicarbonate extruding pathway. The renal expression of pendrin is developmentally adapted and pendrin positive cells originate from both the uretric bud and mesenchyme. In adult kidney, pendrin expression and activity is regulated by systemic acid-base status, dietary electrolyte intake (mostly chloride), and hormones such as angiotensin II and aldosterone which can affect subcellular localization, the relative number of pendrin expressing cells, and the overall abundance consistent with a role of pendrin in maintaining normal acid-base homeostasis. This review summarizes recent findings on the role and regulation of pendrin in the context of the kidneys role in acid-base homeostasis in health and disease.

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Prognostic significance of distal renal tubular acidosis in posterior urethral valve

Cited by 9 publications

References 18 publications

Bicarbonate therapy improves growth in children with incomplete distal renal tubular acidosis

Bicarbonate therapy improves growth in children with incomplete distal renal tubular acidosis

Epidemiology of pediatric urolithiasis

The Anion Exchanger Pendrin (SLC26A4) and Renal Acid-base Homeostasis

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