Prognostic significance of Dickkopf-1 in head and neck squamous cell carcinoma

Chen, Kai; Li, Jin; Ouyang, Yanfeng; Xie, Yulong; Xu, Guiqiong; Xia, Tianliang; You, Rui; Liu, Guichao; He, Han; Huang, Rong; Chen, Mingyuan

doi:10.1080/14737140.2023.2289597

Cited by 2 publications

(1 citation statement)

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“…In prostate cancer, the pro-cancer effect of DKK-1 is related to increased bone metastasis growth and decreased bone induction [ 35 ]. In HNSCC, the expression level of DKK1 was increased in patients with higher T-stage HNSCC, and this increase was related to shorter OS and PFS/DFS [ 36 ]. Our results suggest that DKK1 overexpression in HNSCC is strongly correlated with a range of clinical features, dismal prognosis, and immune filtration.…”

Section: Discussionmentioning

confidence: 99%

Dickkopf-1 is an immune infiltration-related prognostic biomarker of head and neck squamous cell carcinoma

Zhao,

Liu,

et al. 2024

Aging

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Immunotherapy is currently one of the most viable therapies for head and neck squamous cell carcinoma (HNSCC), characterized by high immune cell infiltration. The Wnt-signaling inhibitor and immune activation mediator, Dickkopf-1 (DKK1), has a strong correlation with tumor growth, tumor microenvironment, and, consequently, disease prognosis. Nevertheless, it is still unclear how DKK1 expression, HNSCC prognosis, and tumor-infiltrating lymphocytes are related. To better understand these associations, we examined how DKK1 expression varies across different tumor and normal tissues. In our study, we investigated the association between DKK1 mRNA expression and clinical outcomes. Next, we assessed the link between DKK1 expression and tumor immune cell infiltration. Additionally, using immunohistochemistry, we evaluated the expression of DKK1 in 15 healthy head and neck tissue samples, and the expression of CD3, CD4, and DKK1 in 27 HNSCC samples. We also explored aberrant DKK1 expression during tumorigenesis. DKK1 expression was remarkably higher in HNSCC tissues than in healthy tissues, and was shown to be associated with tumor stage, grade, lymph node metastasis, histology, and a dismal clinical prognosis in HNSCC. DKK1 expression in HNSCC tissues was inversely correlated with CD3+ (P < 0.0001) and CD4+ (P < 0.0001) immune cell infiltration, while that in immune cells was inversely associated with HNSCC prognosis. These findings offer a bioinformatics perspective on the function of DKK1 in HNSCC immunotherapy and provide justification for clinical research on DKK1-targeted HNSCC treatments. DKK1 is a central target for improving the efficacy of HNSCC immunotherapy.

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Section: Discussionmentioning

confidence: 99%