Prognostic significance of cyclooxygenase-2 pathway and angiogenesis in head and neck squamous cell carcinoma

Gallo, Oreste; Masini, Emanuela; Bianchi, Benedetta; Bruschini, Luca; Paglierani, Milena; Franchi, Alessandro

doi:10.1053/hupa.2002.125376

Cited by 200 publications

(203 citation statements)

References 34 publications

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“…Studies investigating this association have reached different conclusions. Three studies (26,27) reported a statistically significant association between the overexpression of VEGF and the presence of lymph node metastasis, whereas other investigations including the present one did not find such association (4,20,28). Accordingly, this would indicate that the expression of VEGF in oral SCC does not play a determinant role in regional lymph node metastasis.…”

Section: Discussioncontrasting

confidence: 45%

Immunohistochemical expression of MMP-9 and VEGF in squamous cell carcinoma of the tongue

et al. 2012

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Section: Discussioncontrasting

confidence: 45%

Immunohistochemical expression of MMP-9 and VEGF in squamous cell carcinoma of the tongue

et al. 2012

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“…Here, we demonstrated that elevated levels of urinary PGE-M were associated with reduced disease-specific and overall survival. These findings are also consistent with prior studies which reported that both elevated COX-2 and PGE 2 at the invasive front of the tumor predict for worse disease-free and overall survival in HNSCC patients (20,47). As mentioned above, PGE 2 has multiple effects that can potentially explain the link between elevated urinary PGE-M and poor prognosis.…”

Section: Discussionsupporting

confidence: 82%

“…COX-2 levels are increased in oral leukoplakia, a premalignant condition (9). Moreover, high levels of COX-2 and PGE 2 have been associated with poor prognosis in HNSCC patients (20). Use of NSAIDs, prototypic inhibitors of PGE 2 synthesis, has been associated with a reduced risk of HNSCC in epidemiologic studies (21,22).…”

Section: Introductionmentioning

confidence: 99%

Elevated Levels of Urinary PGE-M Are Found in Tobacco Users and Indicate a Poor Prognosis for Oral Squamous Cell Carcinoma Patients

Kekatpure

Wang

et al. 2016

Cancer Prevention Research

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Cyclooxygenase-2 (COX-2)-derived prostaglandin E 2 (PGE 2 ) plays a role in the development and progression of epithelial malignancies. Measurements of urinary PGE-M, a stable metabolite of PGE 2 , reflect systemic PGE 2 levels. Here, we investigated whether urinary PGE-M levels were elevated in healthy tobacco users and in patients with oral squamous cell carcinoma (OSCC). Median urinary PGE-M levels were increased in healthy tobacco quid chewers [21.3 ng/mg creatinine (Cr); n ¼ 33; P ¼ 0.03] and smokers (32.1 ng/mg Cr; n ¼ 31; P < 0.001) compared with never tobacco quid chewers-never smokers (18.8 ng/mg Cr; n ¼ 30). Urinary PGE-M levels were also compared in OSCC patients versus healthy tobacco users. An approximately 1-fold increase in median urinary PGE-M level was found in OSCC patients (48.7 ng/mg Cr, n ¼ 78) versus healthy controls (24.5 ng/mg Cr, n ¼ 64; P < 0.001). We further determined whether baseline urinary PGE-M levels were prognostic in OSCC patients who underwent treatment with curative intent. A nearly 1-fold increase in baseline urinary PGE-M levels (64.7 vs. 33.8 ng/mg Cr, P < 0.001) was found in the group of OSCC patients who progressed (n ¼ 37) compared with the group that remained progression free (n ¼ 41). Patients with high baseline levels of urinary PGE-M had both worse disease-specific survival [HR, 1.01 per unit increase; 95% confidence interval (CI), 1.01-1.02; P < 0.001] and overall survival (HR, 1.01 per unit increase; 95% CI, 1.00-1.02; P ¼ 0.03). Taken together, our findings raise the possibility that NSAIDs, prototypic inhibitors of PGE 2 synthesis, may be beneficial for reducing the risk of tobacco-related aerodigestive malignancies or treating OSCC patients with high urinary PGE-M levels. Cancer Prev Res; 9(6); 428-36. Ó2016 AACR.

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“…Consequently, the treatment outcome of these patients does not always correlate with the stage, which is the most important prognostic factor. Recently, COX-2 expression appeared to predict a shorter survival in patients with head and neck cancer (3).…”

Section: Introductionmentioning

confidence: 99%

Expression of Cyclooxygenase (COX)-2 as a Prognostic Factor in Nasopharyngeal Cancer

Kim

Park

et al. 2004

Cancer Res Treat

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P urpose: To evaluate the relationship between treatment failure and C O X -2 expression in nasopharyngeal cancer patients treated with chemotherapy and radiotherapy.M aterials and M ethods: The subjects of this study were 22 nasopharyngeal cancer patients. The patients were treated with neoadjuvant chemotherapy, followed by radiotherapy, or with radiotherapy alone. The formalinfixed, paraffin-embedded tissues of 11 patients who developed a locoregional recurrence (n=7) or distant metastasis (n=4) were compared with those of 11 disease free patients. P rognostic factors, including histological type, stage, radiation dose and chemotherapy, were well balanced between the two groups. The C O X-2 expression was determined immunohistochemically.R esults: C O X -2 expression was stronger in the patients with a locoregional recurrence or distant metastasis than in those free of disease. The C O X -2 distribution scores of the control group were as follows: 0 in 7, 1 in 2 and 2 in 2 patients. In the recurrence group, the scores were as follows; 0 in 3, 1 in 1, 2 in 2 and 3 in 5 patients. COX-2 expression was shown to have a statistically significant influence on the treatment failure by the M ann-W hitney U test (p=0.024) and M antel-H aenszel C hi-S quare test (p=0.018). It also significantly influenced the treatment failure when an analysis was performed within patients with a undifferentiated histology

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Prognostic significance of cyclooxygenase-2 pathway and angiogenesis in head and neck squamous cell carcinoma

Cited by 200 publications

References 34 publications

Immunohistochemical expression of MMP-9 and VEGF in squamous cell carcinoma of the tongue

Immunohistochemical expression of MMP-9 and VEGF in squamous cell carcinoma of the tongue

Elevated Levels of Urinary PGE-M Are Found in Tobacco Users and Indicate a Poor Prognosis for Oral Squamous Cell Carcinoma Patients

Expression of Cyclooxygenase (COX)-2 as a Prognostic Factor in Nasopharyngeal Cancer

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