Prognostic significance of COX-2 and β-catenin in colorectal carcinoma

Kazem, Amani; Sayed, Khaled El; Kerm, Yasser El

doi:10.1016/j.ajme.2013.05.007

Cited by 16 publications

(21 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More deeply invasive tumors (T3/T4) showed a higher grade of expression of b-catenin than superficial tumors (T1/T2). Similar findings have been reported previously both in CRC and in other types of human carcinoma (Moon et al, 2005;Kazem et al, 2014). In the present series also and in agreement with others (Elzagheid et al, 2008;Kazem et al, 2014), high-grade expression of bcatenin was associated with lymph node metastasis.…”

Section: Discussionsupporting

confidence: 95%

“…Similar findings have been reported previously both in CRC and in other types of human carcinoma (Moon et al, 2005;Kazem et al, 2014). In the present series also and in agreement with others (Elzagheid et al, 2008;Kazem et al, 2014), high-grade expression of bcatenin was associated with lymph node metastasis. Most cases of negative node (N0) were grade II b-catenin immunoreactivity, and most cases of positive lymph node (N1/N2) were grade III b-catenin immunoreactivity.…”

Section: Discussionsupporting

confidence: 95%

“…Grade III b-catenin immunoreactivity in both the cytoplasm and nuclei of tumor cells was seen in 23 (39.7%) cases of colorectal carcinoma. Similar results were described in previous studies (Kazem et al, 2014), which found b-catenin reactivity of grade II in 60% of the cases; Grade III b-catenin immunoreactivity in both the cytoplasm and nuclei of tumor cells was seen in 40% of their cases. In this study, no significant correlation was found between b-catenin reactivity and the sex, the age, the tumor localization, or the histological type.…”

Section: Discussionsupporting

confidence: 91%

“…Grade III expression of b-catenin was observed significantly with an increasing tumor grade, findings that are supported by other publications (Willert and Jones, 2006;Kazem et al, 2014). However, others (Cesar Wong et al, 2004) reported lower expression of b-catenin in high-grade tumors.…”

Section: Discussionsupporting

confidence: 70%

“…b-Catenin plays an important role in the WNT signaling pathway. Mutations in Wnt/adenomatous polyposis coli/b-catenin (CTNNB1) signaling pathway members have been found in many colorectal carcinomas (Kazem et al, 2014). Nuclear bcatenin expression provides additional information in predicting the patient outcome in advanced CRC (Elzagheid et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Immunohistochemical study of β-catenin and HER2/neu in colorectal carcinoma

Mohamed¹,

Tealeb²

2015

Egyptian Journal of Pathology

View full text Add to dashboard Cite

Background Colorectal cancer is the third most commonly diagnosed cancer in men and the second in women. b-Catenin plays an important role in the WNT signaling pathway. Mutations in Wnt/adenomatous polyposis coli/b-catenin (CTNNB1) signaling pathway members have been found in many colorectal carcinomas. The human epidermal growth factor receptor 2/neu (HER2/neu) gene is located on the chromosomal region 17q12. It encodes a transmembrane glycoprotein that belongs to the EGF/erbB growth factor receptor family. HER2/neu expression has been reported in colorectal cancer and is one of the most promising targeted therapies in the treatment of this type of malignancy.Aim The aim of this study was to study the significance of b-catenin and HER2/neu expression in colorectal carcinomas in correlation with the histopathological parameters. Materials and methodsThis study included 58 previously diagnosed cases of colonic adenocarcinoma together with the adjacent mucosa of all cases. Immunohistochemical expression of b-catenin and HER2/neu was studied, and correlation of their expression with different histopathologic features was performed.Results A statistically significant relationship was found between b-catenin expression and the tumor grade, the stage, and the lymph node status, whereas the relationship of HER2/neu expression with other parameters was statistically insignificant.Conclusion The evaluation of b-catenin expression combined with other pathologic parameters may yield more accurate information about the prognosis of colonic adenocarcinoma, whereas no such information may be obtained with HER2/neu expression.

show abstract

Section: Discussionsupporting

confidence: 95%

Section: Discussionsupporting

confidence: 95%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Immunohistochemical study of β-catenin and HER2/neu in colorectal carcinoma

Mohamed¹,

Tealeb²

2015

Egyptian Journal of Pathology

View full text Add to dashboard Cite

show abstract

TUSC3 promotes colorectal cancer progression and epithelial-mesenchymal transition (EMT) through WNT/β-catenin and MAPK signalling

Wang

Guo

et al. 2016

J. Pathol.

View full text Add to dashboard Cite

Colorectal cancer (CRC) is one of the most common malignancies and is the second leading cause of cancer death in humans. Tumour suppressor candidate 3 (TUSC3) plays an important role in embryogenesis and metabolism. Deletion of TUSC3 often causes non-syndromic mental retardation. Even though TUSC3 deregulation is frequently observed in epithelial cancers, the function of TUSC3 in CRC has remained unknown. In this study, we observed greater expression of TUSC3 at the mRNA and protein level in clinical colorectal tumour samples compared with paired normal tissues. Gain- and loss-of-function analyses were performed to evaluate the functional significance of TUSC3 in CRC initiation and progression. Immunoblotting, immunofluorescence, and co-immunoprecipitation analyses were used to identify potential pathways with which TUSC3 might be involved. Overexpression of TUSC3 in CRC cells induced epithelial-mesenchymal transition (EMT) in CRC cells, accompanied by down-regulation of the epithelial marker, E-cadherin, and up-regulation of the mesenchymal marker, vimentin. Increased proliferation, migration, and invasion, as well as accelerated xenograft tumour growth, were observed in TUSC3-overexpressing CRC cells, while opposite effects were achieved in TUSC3-silenced cells. In conclusion, our study demonstrated the oncogenic role of TUSC3 in CRC and showed that TUSC3 may be responsible for alternations in the proliferation ability, aggressiveness, and invasive/metastatic potential of CRC through regulating the MAPK, PI3K/Akt, and Wnt/β-catenin signalling pathways.

show abstract

Multiple oncogenic roles of nuclear β-catenin

Kumar

Bashyam

2017

J Biosci

View full text Add to dashboard Cite

β-Catenin is essential for embryonic development and required for cell renewal/regeneration in adult life. Cellular β-catenin exists in three different pools: membranous, cytoplasmic and nuclear. In this review, we focus on functions of the nuclear pool in relation to tumorigenesis. In the nucleus, beta-catenin functions as both activator and repressor of transcription in a context-dependent manner. It promotes cell proliferation and supports tumour growth by enhancing angiogenesis. β-Catenin-mediated signalling regulates cancer cell metabolism and is associated with tumour-initiating cells in multiple malignancies. In addition, it functions as both pro- and anti-apoptotic factor besides acting to inhibit recruitment of inflammatory anti-tumour T-cells. Thus, β-catenin appears to possess a multifaceted nuclear function that may significantly impact tumour initiation and progression.

show abstract

Prognostic significance of COX-2 and β-catenin in colorectal carcinoma

Cited by 16 publications

References 43 publications

Immunohistochemical study of β-catenin and HER2/neu in colorectal carcinoma

Immunohistochemical study of β-catenin and HER2/neu in colorectal carcinoma

TUSC3 promotes colorectal cancer progression and epithelial-mesenchymal transition (EMT) through WNT/β-catenin and MAPK signalling

Multiple oncogenic roles of nuclear β-catenin

Contact Info

Product

Resources

About