2022
DOI: 10.3389/fonc.2022.981036
|View full text |Cite
|
Sign up to set email alerts
|

Prognostic significance of copy number variation in B-cell acute lymphoblastic leukemia

Abstract: Copy number variations (CNVs) are widespread in both pediatric and adult cases of B-cell acute lymphoblastic leukemia (B-ALL); however, their clinical significance remains unclear. This review primarily discusses the most prevalent CNVs in B-ALL to elucidate their clinical value and further personalized management of this population. The discovery of the molecular mechanism of gene deletion and the development of targeted drugs will further enhance the clinical prognosis of B-ALL.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
(2 citation statements)
references
References 86 publications
0
2
0
Order By: Relevance
“…Furthermore, our study showed that prognosis is strongly influenced by the association with CNVs and/or somatic mutations. The prognostic value of CNVs and somatic gene mutations in CLL has been previously reported by others [45][46][47][48] and also by our team [44]. The data of the current study showed similar results, since the presence of somatic mutations (HR = 2.4, 95% CI = 1.01-5.19, p = 0.03) and CNVs (HR = 2.1, 95% CI = 0.99-4.35, p = 0.05) were found to be individual risk factors for OS together with an age above 65 years at diagnosis.…”
Section: Discussionmentioning
confidence: 57%
“…Furthermore, our study showed that prognosis is strongly influenced by the association with CNVs and/or somatic mutations. The prognostic value of CNVs and somatic gene mutations in CLL has been previously reported by others [45][46][47][48] and also by our team [44]. The data of the current study showed similar results, since the presence of somatic mutations (HR = 2.4, 95% CI = 1.01-5.19, p = 0.03) and CNVs (HR = 2.1, 95% CI = 0.99-4.35, p = 0.05) were found to be individual risk factors for OS together with an age above 65 years at diagnosis.…”
Section: Discussionmentioning
confidence: 57%
“…The gain of chromosome 21 in patients with Down Syndrome was associated with leukemogenesis [ 99 ], and gain of chromosome 1q was associated with multiple myeloma (MM) [ 100 ]. Furthermore, the detection and characterization of CNVs could help in monitoring the prognosis of patients with hematologic malignancies such as ALL [ 101 ]. Although WGS improved the efficiency of detecting chromosomal alterations in various hematologic disorders [ 102 ], detecting CNVs can be challenging because they can be difficult to distinguish from noise in sequencing data.…”
Section: Ai-assisted Genomic Testing For Hematologic Disordersmentioning
confidence: 99%