Prognostic significance of combined microRNA-206 and CyclinD2 in gastric cancer patients after curative surgery: A retrospective cohort study

Shi, Huichang; Han, Jun; Yue, Shun; Zhang, Tiecheng; Zhu, Weiguo; Zhang, Dahong

doi:10.1016/j.biopha.2014.12.037

Cited by 20 publications

(16 citation statements)

References 29 publications

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“…Generally, the expression level of identical miR in GIC patients was consistent. For example, Yang et al [2] reported that decreased miR-206 expression correlated with worse OS in GC patient and the finding was confirmed by Shi et al [58]. While there were inversely results from different research institutions for identical miR associated prognosis of GIC patients.…”

Section: Discussionmentioning

confidence: 87%

Prognostic role of microRNAs in human gastrointestinal cancer: A systematic review and meta-analysis

et al. 2017

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BackgroundGastrointestinal cancers (GICs) mainly including esophageal, gastric and colorectal cancer, are the most common cause of cancer-related death and lead into high mortality worldwide. We performed this systematic review and meta-analysis to elucidate relationship between multiple microRNAs (miRs) expression and survival of GIC patients.MethodsWe searched a wide range of database. Fixed-effects and random-effects models were used to calculate the pooled hazard ratio values of overall survival and disease free survival. In addition, funnel plots were used to qualitatively analyze the publication bias and verified by Begg's test while it seems asymmetry.Results60 studies involving a total of 6225 patients (1271 with esophageal cancer, 3467 with gastric cancer and 1517 with colorectal cancer) were included in our meta-analysis. The pooled hazard ratio values of overall survival related to different miRs expression in esophageal, gastric, colorectal and gastrointestinal cancer were 2.10 (1.78-2.49), 2.02 (1.83-2.23), 2.54 (2.14-3.02) and 2.15 (1.99-2.31), respectively. We have identified a total of 59 miRs including 23 significantly up-regulated expression miRs (miR-214, miR-17, miR-20a, miR-200c, miR-107, miR-27a, etc.) and 36 significantly down-regulated expression miRs (miR-433, let-7g, miR-125a-5p, miR-760, miR-206, miR-26a, miR-200b, miR-185, etc.) correlated with poor prognosis in GIC patients. Moreover, 35 of them revealed mechanisms.ConclusionOverall, specific miRs are significantly associated with the prognosis of GIC patients and potentially eligible for the prediction of patients survival. It also provides a potential value for clinical decision-making development and may serve as a promising miR-based target therapy waiting for further elucidation.

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Section: Discussionmentioning

confidence: 87%

Prognostic role of microRNAs in human gastrointestinal cancer: A systematic review and meta-analysis

et al. 2017

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“… 58 – 62 But some studies showed that CCND2 mRNA is overexpressed in GC. 36 , 63 – 65 Therefore, more studies are needed to evaluate the expression of CCND2 in GC to resolve the conflicting picture. In this report, there was no difference of CCND2 expression between GC and normal tissues.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance and biological roles of cyclins in gastric cancer

Zhang¹,

Li²,

Wang³

et al. 2018

OTT

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Background and aimCyclins have been reported to be overexpressed with poor prognosis in several human cancers. However, limited numbers of studies evaluated the expressions and prognostic roles of cyclins in gastric cancer (GC). We aim to evaluate the expressions and prognostic roles of cyclins. Also, further efforts were made to explore biological function of the differentially expressed cyclins.MethodsCyclins expressions were analyzed by Oncomine and The Cancer Genome Atlas datasets, and the prognostic roles of cyclins in GC patients were investigated by the Kaplan–Meier Plotter database. Then, a comprehensive PubMed literature search was performed to identify expression and prognosis of cyclins in GC. Biological functions of the differentially expressed cyclins were explored through Enrich R platform, and KEGG and transcription factor were analyzed.ResultsThe expression levels of CCNA2 (cyclin A2), CCNB1 (cyclin B1), CCNB2 (cyclin B2), and CCNE1 (cyclin E1) mRNAs were identified to be significantly higher in GC tissues than in normal tissues in both Oncomine and The Cancer Genome Atlas datasets. High expressions of CCNA2, CCNB1, and CCNB2 mRNAs were identified to be related with poor overall survival in Kaplan–Meier Plotter dataset. Evidence from clinical studies showed that CCNB1 was related with overall survival in GC patients. Cyclins were associated with several biological pathways, including cell cycle, p53 signaling pathway, FoxO signaling pathway, viral carcinogenesis, and AMPK signaling pathway. Enrichment analysis also showed that cyclins interacted with some certain transcription factors, such as FOXM1, SIN3A, NFYA, and E2F4.ConclusionBased on our results, high expressions of cyclins were related with poor prognosis in GC patients. The above information might be useful for better understanding the clinical and biological roles of cyclins mRNA and guiding individualized treatments for GC patients.

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“…Upregulation of miR-206 differed from miR-1 and tended to serve as a chemoresistance indicator (26). However, when detected alone, repressed miR-206 expression in GC tissues and GC cell lines are consistent in several studies (54)(55)(56)(57)(58). Lin et al compared miR-206 expression in primary GC tissues with those in normal adjacent mucosa from 30 patients, miR-206 expression was found to be significantly decreased in 30 of the GC samples (54).…”

Section: Mirs In Gcmentioning

confidence: 62%

“…In addition, miR-206-low/CCND2-high expression was associated with a significantly worst overall survival of all miR-206/ CCND2 groups (P<0.001). Furthermore, multivariate analysis identified miR-206 and/or CCND2 expression as independent prognostic factors for overall survival in patients with gastric cancer (58).…”

Section: Target Genes and Pathways Involved In The Mir-1 -133 And -2mentioning

confidence: 99%

Insights into roles of the miR-1, -133 and -206 family in gastric cancer (Review)

et al. 2016

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Gastric cancer (GC) remains the third most common cause of cancer deaths worldwide and carries a high rate of metastatic risk contributing to the main cause of treatment failure. An accumulation of data has resulted in a better understanding of the molecular network of GC, however, gaps still exist between the unique bio-resources and clinical application. MicroRNAs are an important part of non-coding RNAs and behave as major regulators of tumour biology, alongside their well-known roles as intrinsic factors of gene expression in cellular processes, via their post-transcriptional regulation of components of signalling pathways in a coordinated manner. Deregulation of the miR-1, -133 and -206 family plays a key role in tumorigenesis, progression, invasion and metastasis. This review aims to provide a summary of recent findings on the miR-1, -133 and -206 family in GC and how this knowledge might be exploited for the development of future miRNA-based therapies for the treatment of GC.

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Prognostic significance of combined microRNA-206 and CyclinD2 in gastric cancer patients after curative surgery: A retrospective cohort study

Cited by 20 publications

References 29 publications

Prognostic role of microRNAs in human gastrointestinal cancer: A systematic review and meta-analysis

Prognostic role of microRNAs in human gastrointestinal cancer: A systematic review and meta-analysis

Clinical significance and biological roles of cyclins in gastric cancer

Insights into roles of the miR-1, -133 and -206 family in gastric cancer (Review)

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