Prognostic significance of clinical stage, histologic grade, and nuclear DNA content in squamous-cell carcinoma of the anus

Goldman, Sven; Auer, Gert; Erhardt, Kerstin; Seligson, U

doi:10.1007/bf02556494

Cited by 48 publications

(18 citation statements)

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“…Others using flow cytometric DNA analysis have failed to demonstrate any DNA aneuploid histograms in even poorly differentiated squamous cell carcinomas of the anus (Fenger & Bichel, 1981). By contrast the very different technique and criteria of photographic cytophotometry classifies most squamous cell anal cancers as aneuploid (Goldman et al, 1987). But even with this much higher incidence of aneuploidy, this latter study could still not demonstrate any correlation between the ploidy of anal cancers and patient prognosis (Goldman et al, 1987).…”

Section: Disoncontrasting

confidence: 57%

“…By contrast the very different technique and criteria of photographic cytophotometry classifies most squamous cell anal cancers as aneuploid (Goldman et al, 1987). But even with this much higher incidence of aneuploidy, this latter study could still not demonstrate any correlation between the ploidy of anal cancers and patient prognosis (Goldman et al, 1987).…”

Section: Disoncontrasting

confidence: 55%

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Carcinoma of the anal canal and flow cytometric DNA analysis

Scott

Beart²,

Weiland³

et al. 1989

Br J Cancer

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Carcinoma of the anal canal is an uncommon malignancy, accounting for only 1-3% of colorectal cancers (Goligher, 1984). Flow cytometric DNA analysis has attracted interest as a possible prognostic tool in patients with colorectal cancer (Wolley et al., 1982; Armitage et al., 1985;Kokal et al., 1986;Quirke et al., 1987; Scott et al., 1987a, b tional 28 patients had been fixed continuously in formalin for a penrod of several years. As the tumour tissue of these 28 patients would not stain satisfactonrly with propidium iodide (Schutte et al., 1985), they also had to be excluded from the study.A DNA histogram was obtained from the anal cancers of 135 patients. DNA histograms with a single GO GI peak were classified as DNA diploid. A DNA diploid ploidy pattern was given by 82 anal canal cancers (cv of GO/GI peak 7.95%).DNA histograms that contained an additional GO/GI peak with a DNA index (DI) value of between 1.10 and 1.99 were classified as DNA aneuploid (Hiddemann et al., 1984); this latter pattern was seen in 15 anal cancers. Finally, DNA ploidy patterns with an especially large G2 peak (mean DI 2.10; s.e.m. 0.05) containing more than 10% of the measured cell nuclei (Tribukait et al., 1982). in the absence of aggregation (no 6c peak), were classified as DNA tetraploid; this category of DNA tetraploid included 20 anal cancers. The DNA histograms of the remaining 18 anal carcinomas were of such poor quality that they could not be classified.Statistical analyses were carred out using the SAS procedures (SAS Program Institute, 1986). The program FREQ was used to test associations of clinicopathological features of the anal canal cancers with their DNA pattern. All P values were determined using the Pearson X2 statistic. The survival curves were generated using the Kaplan-Meier method (Kaplan & Meier, 1958), and univariate survival comparisons were made using the log-rank statistic (Mantel & Haenszel, 1959 (Table I). Similarly, little correlation was seen between tumour ploidy and patient age, although younger patients (less than 45 years) had proportionately more DNA non-diploid patterns (Table I). Large anal cancers (greater than 5cm diameter) gave more DNA non-diploid patterns than smaller anal cancers (Table I).

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Section: Disoncontrasting

confidence: 57%

Section: Disoncontrasting

confidence: 55%

Carcinoma of the anal canal and flow cytometric DNA analysis

Scott

Beart²,

Weiland³

et al. 1989

Br J Cancer

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“…Indeed a median value of 53% (mean value of 56%) represents one of the highest indices reported in the literature for an epithelial cancer. Our results are compatible with the high proliferating cell nuclear antigen indices (means ranging from 66% to 83%) reported by Noffsinger et al (1994) in a series of 34 anal carcinomas, and are consistent with the demonstration by Goldman et al (1987) of tumour aneuploidy in most anal carcinoma specimens studied. Moreover, this high Mib-1 index may shed light on the remarkable radio-and chemosensitivity of these carcinomas.…”

Section: Correlation Of Mib 1 Index With Different End Pointssupporting

confidence: 92%

“…Correlation between Mib-1 index and clinicopathological parameters Because some clinical factors have been reported to be of prognostic value (Salmon et al, 1986;Goldman et al, 1987;Touboul et al, 1994;Allal et al, 1997), correlations of these parameters with Mib-1 indices were studied to assess potential linkage. In addition, a univariate analysis of the present series was undertaken to determine which clinical or therapeutic factors were significantly associated with a decrease in locoregional control.…”

Section: Correlation Of Mib 1 Index With Different End Pointsmentioning

confidence: 99%

Apparent lack of prognostic value of MIB-1 index in anal carcinomas treated by radiotherapy

Allal

Alonso-Pentzke²,

Remadi³

1998

Br J Cancer

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Summary This study was conducted to investigate the influence of Mib-1 index on outcome in 55 patients with T1-4 anal carcinomas treated radically by radiotherapy (RT) alone (24) or by concomitant chemo-radiotherapy (31). Median follow-up for surviving patients was 94 months (range 17-179 months). Tissue materials were obtained from pretreatment biopsies. A modified immunoperoxidase technique consisting of microwave heating of routinely processed material was employed using the Mib-1 antibody (Immunotech, 1:50). The median Mib-1 index for all patients was 53% (range 18-96%). Subgroups of patients with high vs low Mib-1 indices (separated by the median value) had statistically similar outcomes regarding 5-year overall survival (64% vs 65% P = 0.7), locoregional control (77% vs 69%, P = 0.5) and disease-free survival (73% vs 66%, P = 0.5). Moreover, no significant association was found between mean Mib-1 indices and various clinicopathological parameters studied (age, sex, circumferential tumour extent, T-stage, N-stage and histological type). In conclusion, Mib-1 index failed to predict the outcome of patients with anal carcinomas treated conservatively by radiotherapy with or without chemotherapy. It is noteworthy that the median Mib-1 index observed in anal carcinomas in this study was among the highest yet reported for cancers of epithelial origin.

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“…There exists no generally accepted prognostic factors for anal carcinoma (3), but advanced tumour stage (T3-T4) and/or lymph node involvement (NILN3) appear to involve poor prognosis (8, 46, 91, 93 -95). There is a discrepancy in the literature whether histopathological grade and nuclear DNA content of the tumour might be of prognostic value (45,82,92,(93)(94)(95)(96).…”

Section: Chemotherapymentioning

confidence: 99%

Diagnosis and Treatment of Anal Carcinoma: An overview

Tanum

1992

Acta Oncologica

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Prognostic significance of clinical stage, histologic grade, and nuclear DNA content in squamous-cell carcinoma of the anus

Cited by 48 publications

References 10 publications

Carcinoma of the anal canal and flow cytometric DNA analysis

Carcinoma of the anal canal and flow cytometric DNA analysis

Apparent lack of prognostic value of MIB-1 index in anal carcinomas treated by radiotherapy

Diagnosis and Treatment of Anal Carcinoma: An overview

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