Prognostic significance of CD44v6, p63, podoplanin and MMP‐9 in oral squamous cell carcinomas

Monteiro, Luís Silva; Delgado, L.; Ricardo, Sara; Amaral, Barbas do; Salazar, Filomena; Jj, Pacheco; Lopes, Carlos; Bousbaa, Hassan; Warnakulasuryia, S

doi:10.1111/odi.12442

Cited by 33 publications

(66 citation statements)

References 52 publications

(102 reference statements)

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“…MMP‐9 is known to induce tumor angiogenesis, a key factor in tumor progression . Studies have reported a relationship between MMP‐9 expression and the prognosis of patients with oral cancer . Katayama et al and Kosunen et al demonstrated that overexpression of MMP‐9 is associated with cervical lymph node metastasis, an advanced clinical stage, and poor tumor differentiation.…”

Section: Discussionmentioning

confidence: 99%

“…The inflammatory markers TAN, MMP‐9, and IL‐17 have been individually proposed as prognostic biomarkers in oral squamous cell carcinoma (OSCC) . Garley et al and Li et al observed that the supernatants and blood serum of patients with oral cancer exhibit higher concentrations of IL‐17 than those of healthy subjects, and this difference is associated with tumor growth and metastasis .…”

Section: Introductionmentioning

confidence: 99%

“…Garley et al and Li et al observed that the supernatants and blood serum of patients with oral cancer exhibit higher concentrations of IL‐17 than those of healthy subjects, and this difference is associated with tumor growth and metastasis . Most of the clinical studies on TAN and MMP‐9 demonstrate that they are associated with poor clinical outcomes, including decreased survival . Similarly, neoangiogenesis shows a positive relationship with poorer prognosis in OSCC …”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, no study has yet evaluated this set of markers in OSCC samples. In this way, the characterization of co‐expression of these markers (TAN, MMP‐9, IL‐17, and angiogenesis) in OSCC is relevant, as it seems to contribute to events such as extracellular matrix degradation and angiogenesis, which lead to local invasion, progression, spreading of neoplastic cells, and consequently poor clinical outcomes …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Immunohistochemical analysis of neutrophils, interleukin‐17, matrix metalloproteinase‐9, and neoformed vessels in oral squamous cell carcinoma

Silva

Dallarmi

Araujo

et al. 2018

J Oral Pathology Medicine

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Immunohistochemical analysis of neutrophils, interleukin‐17, matrix metalloproteinase‐9, and neoformed vessels in oral squamous cell carcinoma

Silva

Dallarmi

Araujo

et al. 2018

J Oral Pathology Medicine

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show abstract

“…Generally, OSCC patients with elevated TP63 levels have a poorer survival rate. However, inconsistent results regarding the association of TP63 expression with OSCC patient prognosis have also been described [39]. These conflicting results may be attributed to the different demographic characteristics, anatomic sites [40], and spatiotemporal expression patterns of the TP63 isoforms in patients with OSCC.…”

Section: Discussionmentioning

confidence: 99%

Interplay between ΔNp63 and miR-138-5p regulates growth, metastasis and stemness of oral squamous cell carcinoma

Zhuang

Xie²,

et al. 2017

Oncotarget

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TP63 acts as a master regulator in epithelia development and in the progression of various cancers, but its role in oral cancer pathogenesis remains unknown. This study aimed to explore the role of TP63 in the progression of oral squamous cell carcinoma (OSCC). This study shows that ΔNp63, the predominant isoform of TP63, is significantly upregulated in OSCC tissues and cell lines compared with their normal counterparts, and its expression is closely correlated with pathological differentiation, lymph node metastasis and clinical stage in patients with OSCC. The overexpression of ΔNp63 promotes growth, metastasis and stem-like properties in OSCC cells, and ΔNp63 depletion significantly represses OSCC cellular phenotypes in vitro and in vivo. The ΔNp63 isoform transcriptionally suppresses miR-138-5p expression; restoration of miR-138-5p expression partially abolishes the effect of upregulating ΔNp63. This study also demonstrates that miR-138-5p directly targets ΔNp63, resulting in crosstalk with ΔNp63. The correlation between ΔNp63 and miR-138-5p was further validated in OSCC tissues and was found to be significantly associated with the prognosis of patients with OSCC. Therefore, our data reveal that the interplay between ΔNp63 and miR-138-5p promotes OSCC progression by regulating cell growth, metastasis and stemness.

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Guanylate binding protein 5 is an immune‐related biomarker of oral squamous cell carcinoma: A retrospective prognostic study with bioinformatic analysis

Hasegawa,

Amano,

Kihara

et al. 2024

Cancer Medicine

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BackgroundCancer utilizes immunosuppressive mechanisms to create a tumor microenvironment favorable for its progression. The purpose of this study is to histologically characterize the immunological properties of the tumor microenvironment of oral squamous cell carcinoma (OSCC) and identify key molecules involved in the immunological microenvironment and patient prognosis.MethodsFirst, overlapping differentially expressed genes (DEGs) were screened from OSCC transcriptome data in public databases. Correlation analysis of DEGs with known immune‐related genes identified genes involved in the immune microenvironment of OSCC. Next, stromal patterns of tumor were classified and immunohistochemical staining was performed for immune cell markers (CD3, CD4, Foxp3, CD8, CD20, CD68, and CD163), programmed death‐ligand 1 (PD‐L1), and guanylate binding protein 5 (GBP5) in resected specimens obtained from 110 patients with OSCC who underwent resection. Correlations between each factor and their prognostic impact were analyzed.ResultsAmong the novel OSCC‐specific immune‐related genes screened (including ADAMDEC1, CXCL9, CXCL13, DPT, GBP5, IDO1, and PLA2G7), GBP5 was selected as the target gene. Histopathologic analysis showed that multiple T‐cell subsets and CD20‐positive cells were less common in the advanced stages, whereas CD163‐positive cells were more common in advanced stages. The immature type in the stromal pattern category was associated with less immune cell infiltration, lower expression of PD‐L1 in immune cells, lower expression of GBP5 in the stroma, and shorter overall survival and recurrence‐free survival. Expression of GBP5 in the tumor and stroma correlated with immune cell infiltration of tumors and PD‐L1 expression in tumor and immune cells. Patients with low tumor GBP5 expression and high stromal expression had significantly longer overall survival and recurrence‐free survival.ConclusionsThe stromal pattern category may reflect both invasive and immunomodulatory potentials of cancer‐associated fibroblasts in OSCC. GBP5 has been suggested as a potential biomarker to predict the prognosis and therapeutic efficacy of immune checkpoint inhibitors.

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Prognostic significance of CD44v6, p63, podoplanin and MMP‐9 in oral squamous cell carcinomas

Abstract: Podoplanin and MMP-9 together could contribute to tumour progression and dissemination of OSCC. Their combined overexpression showed an adverse effect on survival, suggesting that they could be regarded as important prognostic biomarkers in OSCC.

Cited by 33 publications

References 52 publications

Immunohistochemical analysis of neutrophils, interleukin‐17, matrix metalloproteinase‐9, and neoformed vessels in oral squamous cell carcinoma

Immunohistochemical analysis of neutrophils, interleukin‐17, matrix metalloproteinase‐9, and neoformed vessels in oral squamous cell carcinoma

Interplay between ΔNp63 and miR-138-5p regulates growth, metastasis and stemness of oral squamous cell carcinoma

Guanylate binding protein 5 is an immune‐related biomarker of oral squamous cell carcinoma: A retrospective prognostic study with bioinformatic analysis

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