Prognostic Significance of BMI-1 But Not MEL-18 Expression in Pulmonary Squamous Cell Carcinoma

Abe, Sosei; Yamashita, Shinichi; Miyahara, So; Wakahara, J.; Yamamoto, Leona; Mori, Ryo; Imamura, Naoko; Yoshida, Yasuhiro; Waseda, Ryuichi; Hiratsuka, Masafumi; Shiraishi, Takeshi; Nabeshima, Kazuki; Iwasaki, Atsushi

doi:10.21873/anticanres.11531

Cited by 4 publications

(1 citation statement)

References 23 publications

(23 reference statements)

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“…In addition, several recent studies reported that the upregulation of BMI-1 was associated with poor prognosis in many cancers, including cancer of the renal cell, tongue, uterine, and lung. 17 , 32 , 33 , 34 Therefore, we analyzed the correlations between the salivary BMI-1 levels and clinical outcomes in patients with SACC. Our data showed that patients whose saliva contained high levels of BMI-1 had poor overall and disease-specific survival.…”

Section: Discussionmentioning

confidence: 99%

B-cell specific Moloney murine leukemia virus insertion site 1 contributes to invasion, metastasis, and poor prognosis in salivary adenoid cystic carcinoma

Wang

Zhu

Gao

et al. 2024

Journal of Dental Sciences

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Section: Discussionmentioning

confidence: 99%

B-cell specific Moloney murine leukemia virus insertion site 1 contributes to invasion, metastasis, and poor prognosis in salivary adenoid cystic carcinoma

Wang

Zhu

Gao

et al. 2024

Journal of Dental Sciences

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Prognostic value of Bmi-1 oncoprotein expression in non-small cell lung cancer

Xiong

Kuang

et al. 2018

Frontiers in Laboratory Medicine

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Bmi-1 overexpression as an efficient prognostic marker in patients with nonsmall cell lung cancer

et al. 2017

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Background:The prognostic effect of B-cell-specific Moloney leukemia virus insertion site 1 (Bmi-1) in patients with nonsmall cell lung cancer (NSCLC) remains controversial. We thus performed a meta-analysis to reveal the correlation between Bmi-1 with clinical features and overall survival (OS) in NSCLC.Methods:Relevant studies were searched through PubMed, Embase, and Web of Science. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) as well as odds ratios (ORs) and 95% CIs were calculated by using STATA version 12.0.Results:Fourteen studies consisting of 1323 patients were included for quantitative analysis. The results showed that Bmi-1 was significantly associated with tumor size (n = 7, OR = 1.79, 95% CI = 1.19–2.71, P = .005, fixed effect), poor differentiation (OR = 1.61, 95% CI = 1.11–2.33, P = .011, fixed effect), and distant metastasis (n = 4, OR = 4.69, 95% CI = 1.52–14.41, P = .007, fixed effect). In addition, high Bmi-1 expression also predicted poor OS (HR = 1.62, 95% CI = 1.14–2.3, P < .001). There was no significant publication bias for any of the analyses.Conclusion:In conclusion, Bmi-1 overexpression was correlated with tumor size, poor differentiation, distant metastasis, and worse OS in NSCLC. Therefore, Bmi-1 could be recommended as an efficient prognostic marker for NSCLC.

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Prognostic Significance of BMI-1 But Not MEL-18 Expression in Pulmonary Squamous Cell Carcinoma

Abstract: BMI-1 expression, but not MEL-18, is associated with a favorable prognosis and is a possible prognostic factor of pulmonary squamous cell carcinoma.

Cited by 4 publications

References 23 publications

B-cell specific Moloney murine leukemia virus insertion site 1 contributes to invasion, metastasis, and poor prognosis in salivary adenoid cystic carcinoma

B-cell specific Moloney murine leukemia virus insertion site 1 contributes to invasion, metastasis, and poor prognosis in salivary adenoid cystic carcinoma

Prognostic value of Bmi-1 oncoprotein expression in non-small cell lung cancer

Bmi-1 overexpression as an efficient prognostic marker in patients with nonsmall cell lung cancer

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