Prognostic significance of Bax, Bcl-2, and p53 expressions in cervical squamous cell carcinoma treated by radiotherapy

Wootipoom, Virach; Lekhyananda, Nol; Phungrassami, Temsak; Boonyaphiphat, Pleumjit; Thongsuksai, Paramee

doi:10.1016/j.ygyno.2004.03.012

Cited by 41 publications

(39 citation statements)

References 25 publications

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“…Baalbergen et al [29] found a significantly worse 5-year disease-specific survival if p53 staining was strongly positive in cervical adenocarcinoma cases. Overexpression of p53 and Bcl-2 provides independent prognostic information for the poor disease-free survival in cervical cancer cases [47] . Precursor lesions of the cervix persist longer and progress more quickly in women with oncogenic HPV infection than in women with non-oncogenic infections or without HPV [48] .…”

Section: Discussionmentioning

confidence: 99%

Co-Expression of p53 and Bcl-2 Proteins in Human Papillomavirus-Induced Premalignant Lesions of the Uterine Cervix: Correlation with Progression to Malignancy

Singh¹,

Srivastava²,

Singh³

et al. 2009

Tumor Biol

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Objective(s): To analyze aberrant expression of the apoptotic protein p53 and the anti-apoptotic protein Bcl-2 in premalignant lesions of the uterine cervix induced by human papillomavirus (HPV) infection and its significance for early diagnosis of cervical cancer. Materials and Methods: Cytological adequate smears (n = 382) from various grades of squamous intraepithelial lesions (SILs; n = 142), ‘atypical squamous cells of unknown significance’ (ASCUS; n = 128) and normal tissue (n = 112) were investigated immunocytochemically for aberrant expression of p53 and Bcl-2 proteins using the streptavidin-biotin-peroxidase method; HPV status was analyzed in cervical smears using general and type-specific primers. Results: HPV-DNA of any type was detected in 25.7% (98/382) of cases. HPV16 was seen in 58.2% (57/98), HPV18 in 20.4% (20/98) and other HPV types in 21.4% (21/98). Abnormal nuclear expression of p53 protein and cytoplasmic expression of Bcl-2 protein were noted in cervical dysplasia and an association with the presence of HPV16/HPV18 was noted. The intensity of immunoreactivity for p53 and Bcl-2 proteins varied between different cytological grades of cervical smears. Follow-up data revealed that cases with high-risk HPV and co-induced expression of apoptosis-regulatory proteins presented a trend to progressive disease. Conclusions: The detection of both p53 and Bcl-2 proteins in cervical smears can be used as independent diagnostic marker for early-stage HPV-associated cervical cancer.

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Section: Discussionmentioning

confidence: 99%

Co-Expression of p53 and Bcl-2 Proteins in Human Papillomavirus-Induced Premalignant Lesions of the Uterine Cervix: Correlation with Progression to Malignancy

Singh¹,

Srivastava²,

Singh³

et al. 2009

Tumor Biol

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“…In order to establish a new predictor of the outcome of radiotherapy for human cervical carcinoma, Harima et al, (1998) established that the increased Bcl2 expression after radiotherapy is correlated with poor survival, while increased Bax expression after radiotherapy is correlated with good survival; these findings suggest that the levels of Bax and Bcl2 expression after radiotherapy are useful prognostic markers in patients with human cervical carcinoma (Harima et al, 1998). Some studies confirm that evaluation of Bax and Bcl2 expressions provide independent prognostic information for the clinical course of the disease and therefore could be developed as prognostic indicators for cervical cancer: Bax expression was associated with good survival while Bcl2expression was associated with poor survival, and combination of Bcl2+/Bax+ was significantly associated with poorer disease free survival (Wootipoom et al, 2004).…”

Section: Wwwintechopencommentioning

confidence: 82%

The Indicators of Predicting Disease Outcome in HPV Carcinogenesis

Bleoţu¹,

Anton²

2012

Topics on Cervical Cancer With an Advocacy for Prevention

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“…Cervical cancers with Bcl-2 expression have been reported to exhibit radiation resistance and poor prognoses (39)(40)(41). However, contradictory results have also been found in terms of Bcl-2 expression and patient prognosis (42)(43)(44)(45)(46)(47)(48)(49).…”

Section: Hdra Developed By Hoffman Et Almentioning

confidence: 99%

Factors affecting platinum sensitivity in cervical cancer

et al. 2015

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Abstract. The present study aimed to investigate the association between nedaplatin (NDP) sensitivity and the expression of biological factors in cervical cancer. A total of 45 cervical cancer specimens, including 18 pretreatment biopsies and 27 surgical specimens, were used in histoculture drug response assays to determine the chemosensitivity of cervical cancer specimens to NDP. Each specimen was assessed for immunohistochemical expression of Ki-67, p53, B-cell lymphoma-2 (Bcl-2), Bcl-2-associated X protein (Bax), cleaved caspase-3, cyclooxygenase-2 (COX-2), and excision repair cross-complementation group 1 (ERCC1). The results revealed that low or negative expression of p53, Bcl-2 and COX-2, and high or positive expression of cleaved caspase-3 were significantly correlated with high sensitivity to NDP. However, there were no significant differences in Ki-67, Bax or ERCC1 expression between the low and high sensitivity groups. These findings indicate that sensitivity to platinum may be easily predicted by immunostaining for the detection of these specific factors in pretreatment biopsies or surgical specimens. The expression profiles of these targets may therefore provide additional information for planning individualized chemotherapy in the treatment of cervical cancer.

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Prognostic significance of Bax, Bcl-2, and p53 expressions in cervical squamous cell carcinoma treated by radiotherapy

Cited by 41 publications

References 25 publications

Co-Expression of p53 and Bcl-2 Proteins in Human Papillomavirus-Induced Premalignant Lesions of the Uterine Cervix: Correlation with Progression to Malignancy

Co-Expression of p53 and Bcl-2 Proteins in Human Papillomavirus-Induced Premalignant Lesions of the Uterine Cervix: Correlation with Progression to Malignancy

The Indicators of Predicting Disease Outcome in HPV Carcinogenesis

Factors affecting platinum sensitivity in cervical cancer

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