Prognostic significance of Bax and Fas Ligand in erionite and asbestos induced Turkish malignant pleural mesothelioma

Köktürk, Nurdan; Firat, Pınar; Akay, Hadı; Kadılar, Cem; Öztürk, Can; Zorlu, Faruk; Güngen, Yücel; Emri, Salïh

doi:10.1016/j.lungcan.2005.05.025

Cited by 21 publications

(21 citation statements)

References 32 publications

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“…41 The reduced level of this tumor suppressor has been associated with a poor outcome. 42 Despite the expression of multiple antiapoptotic BCL2 family members, 43,44 expression of these proteins does not predict an outcome consistent with findings in vitro. 45,46 Global gene-expression analysis has identified a four-gene signature comprising KIAA097, GDP-dissociation inhibitor 1 (GDIA1), cytosolic thyroid hormone-binding protein (CTHBP) and an expressed sequence tag similar to the L6 tumor antigen, which correctly classified a training sample into good and poor prognostic groups.…”

Section: Biological Prognostic Factorsmentioning

confidence: 85%

Advances in the systemic therapy of malignant pleural mesothelioma

et al. 2008

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Malignant pleural mesothelioma is an aggressive thoracic malignancy associated with exposure to asbestos, and its incidence is anticipated to increase during the first half of this century. Chemotherapy is the mainstay of treatment, yet sufficiently robust evidence to substantiate the current standard of care has emerged only in the past 5 years. This Review summarizes the evidence supporting the clinical activity of chemotherapy, discusses the use of end points for its assessment and examines the influence of clinical and biochemical prognostic factors on the natural history of malignant pleural mesothelioma. Early-phase clinical trials of second-line and novel agents are emerging from an increased understanding of mesothelioma cell biology. Coupled with high-quality translational research, such developments have real potential to improve the outlook of patients at a time of increasing incidence.

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Section: Biological Prognostic Factorsmentioning

confidence: 85%

Advances in the systemic therapy of malignant pleural mesothelioma

et al. 2008

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“…A recent study similarly showed co-expression of the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1, with variable loss of expression of the anti-apoptotic Bad, Bak, Bax, Bid, and Bim [142]. Expression of Fas ligand and loss of Bax were recently shown to correlate with shorter survival [143]. Silencing methylation of TNF-related apoptosis-inducing ligand (TRAIL) receptors has been found in various cancers, including clinical specimens and MM cell lines, documenting an important mechanism for the evasion of apoptosis [144].…”

Section: Apoptosis and Cell Cycle Moleculesmentioning

confidence: 88%

New Diagnostic and Molecular Characteristics of Malignant Mesothelioma

Davidson

2008

Ultrastructural Pathology

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Malignant mesothelioma is a primary cancer of the serosal cavities, an anatomic site that is also frequently affected by metastatic disease, predominantly from primary carcinomas of the lung, breast, and ovary. Advances in immunohistochemistry have resulted in improved diagnostic sensitivity and specificity in the differential diagnosis between metastatic adenocarcinoma and malignant mesothelioma in both cytological and histological material. Recently, the author's group applied high throughput technology to the identification of new markers that may aid in differentiating malignant mesothelioma from ovarian and peritoneal serous carcinoma, tumors with closely related histogenesis and antigenic profile. In addition to the improved tools available for serosal cancer diagnosis, knowledge regarding the biology of malignant mesothelioma has been accumulating in recent years. This review presents current data regarding the diagnostic and biological aspects of malignant mesothelioma.

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“…3 pRb immunoreaction in exposed lung. Immunolocalization in bronchial epithelium (940) pathophysiology of interstitial lung disease related to asbestos and asbestos-like materials (Lee et al 1997;Kokturk et al 2005).…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical expression of retinoblastoma and phospho-retinoblastoma protein in lung sheep exposed to fluoro-edenite fibers

et al. 2009

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The immunohistochemical expression of retinoblastoma protein (Rb) and its phosphorylated form (pRb) was investigated in an in vivo sheep model, i.e., lung tissue exposed to asbestos-like fibers. Rb is a phosphoprotein with a central role in controlling the cell cycle, cell growth regulation, differentiation, and apoptosis. pRb functions as a checkpoint in the G(1) phase, favoring cell growth, while the hypophosphorylated form (Rb) not only promotes cell-cycle arrest and a return to the G(1) phase, but also appears to be a key player in most instances of apoptosis. pRb overexpression was detected in alveolar epithelium and the interstitium, especially close to the fluoro-edenite fibers, whereas Rb immunostaining was faint or absent. The data suggest that the altered balance between pRb and Rb expression may be a programmed response to protect the organism against uncontrolled cell proliferation.

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Prognostic significance of Bax and Fas Ligand in erionite and asbestos induced Turkish malignant pleural mesothelioma

Cited by 21 publications

References 32 publications

Advances in the systemic therapy of malignant pleural mesothelioma

Advances in the systemic therapy of malignant pleural mesothelioma

New Diagnostic and Molecular Characteristics of Malignant Mesothelioma

Immunohistochemical expression of retinoblastoma and phospho-retinoblastoma protein in lung sheep exposed to fluoro-edenite fibers

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