Prognostic significance of atherogenic index of plasma, atherogenic coefficient and lipoprotein combined index among elderly patients with non-ST-segment elevation myocardial infarction in 1-year follow-up

Abstract

OBJECTIVES: Coronary artery disease (CAD) remains a leading cause of death in elderly patients. Recently, novel lipoproteins-Atherogenic Index of Plasma (AIP), Atherogenic Coeffi cient (AC) and Lipoprotein Combine Index (LCI) have been suggested as CAD risk factors; their clinical usefulness, however, remains unknown. The aim of the study was to assess the predictive value of AIP, AC and LCI concerning incidence of major adverse cardiovascular events (MACE) and all-cause mortality in 1-year follow-up. METHODS: For the study, 1,083 patients, aged 60 or older, with NSTEMI were enrolled and divided into two groups: young-old and old-old. RESULTS: MACE occurred in 11.8 % of the patients; LCI showed a borderline signifi cance, but only in univariate analysis. Analysis in groups revealed ambiguous results. None of the examined indices was a predictor of MACE in the young-old group whereas all three of them were signifi cant, but negative predictors in the old-old group. Finally, all-cause mortality at follow-up was 14.9 %. AC predicted 1-year mortality in the whole study population (OR = 1.1 (95% CI: 1-1.2; p = 0.02), but was insignifi cant in the multivariable model. Additionally, it was an independent predictor in the old-old group, but with borderline signifi cance (OR = 1.14 (95% CI: 1-1.3, p = 0.036). CONCLUSIONS: AIP, AC and LCI should not be used as predictors of MACE and 1-year mortality among elderly patients with NSTEMI (Tab. 5, Ref. 23).

Association between nontraditional lipid parameters and cardiovascular outcomes in patients undergoing percutaneous coronary intervention: a retrospective study

“…While some studies support the predictive value of AIP for adverse cardiovascular ontcomes in patients with CAD (33,34), con icting conclusions have also been reported. One study by Drwila et al found that AIP was not a signi cant predictor of MACCEs and all-cause mortality at one year (35). The inconsistencies of these studies may be attributed to the difference of age, ethnicity, gender and CAD severity among enrolled population.…”

Effect of selected cardiovascular factors on mortality in patients with ST-segment elevation myocardial infarction treated with primary coronary intervention

“…Among the factors, many of them increase the risk of the atherosclerotic disease per se. Out of lipid spectrum disorders, LDL (low-density lipoprotein) cholesterol has been specifi cally identifi ed as a factor contributing to the atherosclerosis development, while statin treatment aimed U n c o r r e c t e d at reducing the level of LDL-cholesterol contributes to the reduction in the risk of cardiovascular events (3)(4)(5)(6)(7).…”