Prognostic significance of APACHE II score and plasma suPAR in Chinese patients with sepsis: a prospective observational study

Li, Xuan; Shen, Yong; Liu, Zhihua; Fei, Aihua; Wang, Hairong; Ge, Qinmin; Pan, Shuming

doi:10.1186/s12871-016-0212-3

Cited by 29 publications

(25 citation statements)

References 26 publications

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“…The median scorings in APACHE II and SAPS II were 25 and 56 points in the study group, which were much higher than in the above cited papers. Multi-organ failure may significantly interfere with the observations regarding the relationship between NLR and mortality [ 20 , 21 ]. However, this drawback could be interpreted as the strength of our research.…”

Section: Discussionmentioning

confidence: 99%

Haemogram-Derived Indices for Screening and Prognostication in Critically Ill Septic Shock Patients: A Case-Control Study

Liberski¹,

Szewczyk²,

Krzych³

2020

Diagnostics

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This study aimed (1) to assess the diagnostic accuracy of neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), monocyte-to-lymphocyte (MLR) and platelet count-to-mean platelet volume (PLT/MPV) ratios in predicting septic shock in patients on admission to the intensive care unit (ICU) and (2) to compare it with the role of C-reactive protein (CRP), procalcitonin (PCT) and lactate level. We also sought (3) to verify whether the indices could be useful in ICU mortality prediction and (4) to compare them with Acute Physiology and Chronic Health Evaluation II (APACHE II), Simplified Acute Physiology Score II (SAPS II) and Sequential Organ Failure Assessment (SOFA) scores. This retrospective study covered 138 patients, including 61 subjects with multi-organ failure due to septic shock (study group) and 77 sex- and age-matched controls. Septic patients had significantly higher NLR (p < 0.01) and NLR predicted septic shock occurrence (area under the ROC curve, AUROC = 0.66; 95% CI 0.58–0.74). PLR, MLR and PLT/MPV were impractical in sepsis prediction. Combination of CRP with NLR improved septic shock prediction (AUROC = 0.88; 95% CI 0.81–0.93). All indices failed to predict ICU mortality. APACHE II and SAPS II predicted mortality with AUROC = 0.68; 95% CI 0.54–0.78 and AUROC = 0.7; 95% CI 0.57–0.81, respectively. High NLR may be useful to identify patients with multi-organ failure due to septic shock but should be interpreted along with CRP or PCT. The investigated indices are not related with mortality in this specific clinical setting.

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Section: Discussionmentioning

confidence: 99%

Haemogram-Derived Indices for Screening and Prognostication in Critically Ill Septic Shock Patients: A Case-Control Study

Liberski¹,

Szewczyk²,

Krzych³

2020

Diagnostics

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“…In another study, APACHE II score at discharge was found to be able to predict the readmission to neurosurgery ICU, when the score is > 8.5, the patients may be suggested to extend ICU stay to reduce the readmission risk [15]. Compared with GCS score, APACHE II score was found to have better sensitivity and specificity in predicting the mortality of patients with brain traumatic injury [16] and if APACHE II score is ≥ 15, it predicts poor prognosis and low mortality [20].…”

Section: Discussionmentioning

confidence: 96%

Analysis of anesthesia-related prognostic indicators in neurosurgery

Shu

Wang

Chen

et al. 2019

Preprint

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Background: This retrospective study was conducted to identify prognostic predictors for patients undergoing neurosurgery under general anesthesia.Methods: From April 2015 to May 2017, a total of 757 patients undergoing neurosurgery in our hospital were analyzed. Baseline and clinical data including age, gender, etiology, surgery procedures, comorbid and underlying diseases, the Glasgow coma scale (GCS), the APACHE II score, ASA score, anesthesia class, operation time, intraoperative cardiac events, intraoperative blood transfusion, and postoperative fever were collected and analyzed. The Glasgow outcome scale (GOS) was used as outcome measure. Logistic regression analysis was performed to identify the independent prognostic factors. Results: Among the 14 factors analyzed, twelve were significantly correlated to the GOS scores (P < 0.05), including age, etiology, type of surgery, hypertension, anesthesia class, APACHE II score and ASA class, intraoperative cardiac events, intraoperative blood transfusion and postoperative fever. Further logistic regression analysis showed the three parameters had prognostic values with odds ratios of 3.933, 1.812 and 2.910, respectively. On other hand, gender and operation time were not correlated to GOS.Conclusions: Anesthesia class, APACHE II score and ASA class have significant prognostic values for patients undergoing neurosurgical surgery.

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“…In our study, we found that the SOFA score and APACHE II score within 24 hours after entering ICU were statistically signi cant in the univariate analysis, while the multivariate analysis showed that only APACHE II score 20 was an independent risk factor in this group. However, there was evidence that APACHE II score might provide inaccurate information in some patients, for example, in patients with unconsciousness, the score might be too high [26] . Therefore, we need to increase the sample size to con rm this result in the future.…”

Section: Discussionmentioning

confidence: 99%

The Prognostic Factors in Patients With Sepsis After Operation of Gastrointestinal Tumors

Chen

et al. 2020

Preprint

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BackgroundWe studied the clinical profiles and the prognostic factors in patients with sepsis after thegastrointestinal tumor surgery in ICU.MethodsWe retrospectively screened patients who underwent the gastrointestinal tumor surgery at the Peking University Cancer Hospital from January 2015 to December 2019. Among them, 181 patients who were diagnosed with sepsis in ICU were enrolled in our study. Cox regression was performed for multivariate adjusted factor analyses.ResultsThe 90-day all-cause mortality rate was 11.1% in our study. The univariate analysis showed that BMI, shock within 48 h after entering ICU, number of blood leukocytes, the ratio of lymphocytes to neutrophils, INR, creatinine, procalcitonin, lactic acid, oxygenation index, SOFA score within 24 h after entering ICU, APACHE II score within 24 h after entering ICU were statistically significant. In multiple analysis, we found that BMI༞20 kg/m2 was a protective factor, while lactic acid༞3 mmol/L after entering the ICU and APACHE II score༞20 within 24 h after entering ICU were independent risk factors on the prognosis of sepsis after the gastrointestinal tumor surgery in ICU.ConclusionThe 90-day all-cause mortality rate was 11.1% in our study. BMI>20 kg/m2 was a protective factor, while lactic acid>3 mmol/L after entering the ICU and APACHE II score>20 within 24 h after entering ICU were independent risk factors on the prognosis of sepsis after the gastrointestinal tumor surgery in ICU.

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Prognostic significance of APACHE II score and plasma suPAR in Chinese patients with sepsis: a prospective observational study

Cited by 29 publications

References 26 publications

Haemogram-Derived Indices for Screening and Prognostication in Critically Ill Septic Shock Patients: A Case-Control Study

Haemogram-Derived Indices for Screening and Prognostication in Critically Ill Septic Shock Patients: A Case-Control Study

Analysis of anesthesia-related prognostic indicators in neurosurgery

The Prognostic Factors in Patients With Sepsis After Operation of Gastrointestinal Tumors

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