Prognostic significance and potential therapeutic target of VEGFR2 in hepatocellular carcinoma

Huang, Jianfei; Zhang, Xialing; Tang, Qi; zhang, Feng; Li, Yuhua; Feng, Zijian; Zhu, Jin

doi:10.1136/jcp.2010.085142

Cited by 77 publications

(69 citation statements)

References 32 publications

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“…Moreover, the high expression of VEGFR-2 in HCC was related to large tumor diameter (p=0.012), poor differentiation (p=0.007), high serum -fetoprotein (p=0.029), multifocal gross classification (p=0.007), and less than 5 years' survival (p=0.029). In addition, Kaplan-Meier survival and regression analyses showed that high VEGFR-2 expression (p=0.009) and stage grouping were independent prognostic factors (Huang et al 2011). Anti-VEGFR-2 therapy is a promising novel potential therapy for HCC (Lang et al 2008).…”

Section: Liver Cancermentioning

confidence: 98%

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Regulation of Angiogenesis in Human Cancer via Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2)

Guo¹,

Colbert²,

McGlothen³

et al. 2012

Tumor Angiogenesis

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Section: Liver Cancermentioning

confidence: 98%

“…HCC accounts for 90% of all malignant liver tumors. This typically highly vascular tumor is the fifth most common type of cancer and ranks as the third leading cause of cancer www.intechopen.com related deaths worldwide (Huang et al 2011). It has been well established that VEGF plays a critical role in angiogenesis.…”

Section: Liver Cancermentioning

confidence: 99%

Regulation of Angiogenesis in Human Cancer via Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2)

Guo¹,

Colbert²,

McGlothen³

et al. 2012

Tumor Angiogenesis

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“…The KDR staining intensity was also scored into 4 grades as the following: 0, 1, 2, and 3. The sum of the percentage and intensity scores was used as the final KDR staining score as described earlier by us (Huang et al 2011b). …”

Section: Immunohistochemistrymentioning

confidence: 99%

The patterns and expression of KDR in normal tissues of human internal organs

et al. 2011

Self Cite

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KDR has been implicated for playing an important role in the formation of new blood vessels and in solid tumor growth. It was considered as one of the most important regulators of angiogenesis and a key target in anticancer treatment. In the present study, we characterized KDR mRNA and protein expression in normal tissues of perinatal and adult tissues using One-step Real-Time RT-PCR and immunohistochemistry with a self-made anti-KDR antibody. The expression of KDR mRNA and protein in perinatal internal organs were all higher than in adult organs including brain, kidney, liver, lung and heart, respectively. KDR protein was presented in the cell plasma membrane of human internal tissues. The expression of KDR protein was raised in macrophage of spleen, and decreased in neurons of brain, myocardium, bronchial epithelial cells and alveolar epithelial cell, proximal and distal tubules cells, and hepatic cells with the maturity process of human organs. Notably, the order of KDR protein expression from highest to lowest is as follows: brain, liver, heart, kidney, and lung in adult tissues with statistically significant. It follows that how to balance the potential therapeutic side effect with human internal organs in targeted therapy of over-expressing KDR tumor.

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“…Increased VEGFR-2 expression correlates with the stage of disease and the invasiveness of the phenotype. Hepatocellular carcinomas also show a correlation between high VEGFR-2 expression and prognostic significance [7]. High VEGFR-2 expression is significantly related to a large tumor diameter, poorly differentiated tumors, and short survival.…”

Section: Introductionmentioning

confidence: 99%

The mechanisms that regulate the localization and overexpression of VEGF receptor-2 are promising therapeutic targets in cancer biology

Kampen¹

2012

Anti-Cancer Drugs

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The vascular endothelial growth factor (VEGF) family has been proposed to be the most important signaling protein family in vessel formation and maturation. VEGF receptor-2 (VEGFR-2) plays an abundant role in the most common forms of cancer. The localization of VEGFR-2 expression is important in cancer pathogenesis; however, so far, little attention has been paid to this phenomenon. Induced cytoplasmic VEGFR-2 transition from the nucleus is associated with poor prognostic cancer stages. Current VEGFR-2-targeted therapy approaches are effective in inhibiting or arresting tumor growth. Moreover, VEGFR-2-targeted therapy was demonstrated to restore the abnormal vasculature in tumors, enhancing their susceptibility toward conventional therapy. Most effects can be found when VEGFR-2-targeted therapy inhibits not only the induced angiogenesis but also the cancer cells that sometimes overexpress VEGFR-2. Nevertheless, we still have little knowledge about the mechanisms that regulate VEGFR-2 expression and how its localization is exactly involved in cancer prognosis. Further research and evaluation of VEGFR-2 regulation and its nuclear transition is necessary to develop more accurate therapeutic strategies to improve the patients' quality of life and their survival.

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Prognostic significance and potential therapeutic target of VEGFR2 in hepatocellular carcinoma

Abstract: The efficacy of A8H1 in immunohistochemistry using HCC tissues was confirmed. There was a correlation of high VEGFR2 expression with prognostic significance in HCC. Additionally, the self-made anti-VEGFR2 monoclonal antibody could be used for future anti-HCC-targeted therapy research.

Cited by 77 publications

References 32 publications

Regulation of Angiogenesis in Human Cancer via Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2)

Regulation of Angiogenesis in Human Cancer via Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2)

The patterns and expression of KDR in normal tissues of human internal organs

The mechanisms that regulate the localization and overexpression of VEGF receptor-2 are promising therapeutic targets in cancer biology

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