Prognostic scores based on the preoperative plasma fibrinogen and serum albumin level as a prognostic factor in patients with upper urinary tract urothelial carcinoma

Cui, Jianfeng; Yu, Meng; Zhang, Ning; Wang, Shiyu; Zhu, Yao; Chen, Shouzhen; Zhu, Ke-Cheng; Du, Jin; Zhao, Hongda; Liu, Xigao; Chen, Pengxiang; Wang, Wenbo; Zhang, Dongqing; Shi, Benkang

doi:10.18632/oncotarget.16483

Cited by 12 publications

(16 citation statements)

References 29 publications

(45 reference statements)

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“…The FA score, which is based on preoperative fibrinogen and albumin, was developed as a scoring system to reflect inflammation and the nutrition status by Matsuda and has been recognized as a novel clinical prognostic biomarker in several cancers, showing superior predictive power in esophageal cancer patients. 19 , 20 Consistent with these findings, our results indicate that the FA score is an independent prognostic biomarker of PFS and OS in skull base chordoma patients. The FA score may be a valuable clinical score for the assessment of survival due to its relatively low cost and easy accessibility in daily practice.…”

Section: Discussionsupporting

confidence: 86%

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<p>Prognostic Value of Cumulative Score Based on Preoperative Fibrinogen and Albumin Level in Skull Base Chordoma</p>

Li¹,

Bai²,

Wang³

et al. 2020

OTT

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Objective Inflammation and malnutrition have been shown to be correlated with tumor progression and a poor prognosis in various cancers. However, the clinical implications of biomarkers of inflammation and malnutrition in chordoma have not been elucidated. We attempted to characterize the fibrinogen and albumin levels in skull base chordoma and investigate their correlations with clinicopathological data and survival. Methods The preoperative levels of fibrinogen and albumin were assessed in 183 primary skull base chordoma patients. The cutoff values were determined by X-tile software, and their correlations with patient prognosis were further explored using the Kaplan–Meier curve and Cox proportional hazards regression analysis. In addition, the predictive performances of these markers in survival were evaluated by receiver operating characteristic curves. Results The values of fibrinogen and albumin in skull base chordoma patients ranged from 1.73 to 7.40 and 37.6 to 53.0 g/L, respectively. The optimal cutoff values for fibrinogen and albumin were 3.29 and 44.60 g/L, respectively. Fibrinogen and albumin were correlated with the patient age and tumor pathology types. Albumin, but not fibrinogen, was associated with the patients’ progression-free survival and overall survival. Importantly, the FA score, which combines fibrinogen and albumin, could independently predict both progression-free survival and overall survival, and enhanced the performance of fibrinogen or albumin in survival prediction in skull base chordoma. Conclusion Our data reveal the clinical prognostic role of albumin and suggest that the FA score may be a valuable prognostic grading system in skull base chordoma.

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Section: Discussionsupporting

confidence: 86%

“… 17 , 18 Furthermore, considering the prognostic role of fibrinogen and albumin, the FA score, which is a novel scoring system that combines fibrinogen and albumin, has recently been reported, and this score can independently predict outcomes in patients with esophageal cancer and urothelial carcinoma. 19 , 20 …”

Section: Introductionmentioning

confidence: 99%

<p>Prognostic Value of Cumulative Score Based on Preoperative Fibrinogen and Albumin Level in Skull Base Chordoma</p>

Li¹,

Bai²,

Wang³

et al. 2020

OTT

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“…In addition to our analysis, recent studies also indicated a positive correlation between elevated plasma fibrinogen levels and poorer prognosis in other solid tumors including esophageal carcinoma, 37 – 39 small cell lung carcinoma, 40 non-small cell lung carcinoma, 41 upper urinary tract urothelial carcinoma, 42 , 43 epithelial ovarian cancer, 44 colorectal cancer, 45 renal cell carcinoma, 46 , 47 and gastric cancer. 48 , 49 There are several theories that may explain this association: 1) tumor progression is usually coupled with elevated inflammatory responses and leukocyte infiltration into tumor stroma.…”

Section: Discussionsupporting

confidence: 65%

Prognostic value of plasma fibrinogen in hepatocellular carcinoma: a meta-analysis

Huang¹,

Jiang²,

Lin³

et al. 2018

CMAR

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BackgroundElevated plasma fibrinogen levels have been associated with tumor progression in several malignancies. Our study aims to characterize the clinical significance of elevated plasma fibrinogen levels in patients with hepatocellular carcinoma (HCC).Materials and methodsRelevant published articles were systematically searched in electronic databases including PubMed, Embase, and Web of Science. The pooled differences in plasma fibrinogen levels among HCC, cirrhotic, and control groups were expressed as weighted mean differences (WMDs) and their corresponding 95% CIs. The associations between elevated fibrinogen and overall survival (OS) and disease-free survival (DFS)/recurrence-free survival (RFS) were expressed as HRs and their 95% CIs, whereas the associations between elevated fibrinogen and various types of clinical characteristic of patients with HCC were expressed as ORs and their corresponding 95% CIs.ResultsResults showed that the plasma fibrinogen levels in patients with HCC were not significantly different than that in healthy controls (WMD = 0.50, 95% CI = [−0.82, 1.82], P = 0.457) or patients with cirrhosis (WMD = −0.62, 95% CI = [−1.56, 0.33], P = 0.200). However, our results showed that compared to those with normal levels, patients with HCC and elevated plasma fibrinogen levels showed poorer OS (HR = 2.08, 95% CI = [1.67, 2.59], P < 0.0001) and DFS/RFS (HR = 1.90, 95% CI = [1.52, 2.37], P < 0.0001). Results of trial sequential analysis of the OS indicated that currently available studies were sufficient to validate the negative prognostic value of elevated plasma fibrinogen in patients with HCC. Clinicopathological analyses showed that high plasma fibrinogen levels were associated with tumor progression as indicated by advanced tumor stage, larger tumor size, increased tumor number, and the presence of vascular invasion.ConclusionElevated plasma fibrinogen levels are associated with poor prognosis and advanced tumor progression. Plasma fibrinogen may serve as a negative prognostic biomarker in patients with HCC.

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“…Hypoproteinemia is indicative of systemic inflammatory response, and ALB level is a well-known biomarker for malnutrition. 24 Low PAB levels also indicate depletion of protein resulting from LG chronic inflammation. 40 …”

Section: Discussionmentioning

confidence: 99%

Preoperative serum apolipoprotein A-I levels predict long-term survival in non-muscle-invasive bladder cancer patients

Shang

Wang

et al. 2018

CMAR

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IntroductionThe aim of this study was to elucidate the association between apolipoprotein A-I (Apo A-I) and overall survival (OS) as well as cancer-specific survival (CSS) in non-muscle-invasive bladder cancer (NMIBC) patients undergoing transurethral resection of bladder tumor (TURBT).Patients and methodsWe retrospectively collected data of 470 eligible patients diagnosed with NMIBC and who received TURBT between January 2004 and December 2011. Pretreatment blood indexes were examined. The association of Apo A-I with clinicopathological characteristics was further analyzed by dichotomizing our sample into those with Apo A-I ≤ 1.19 g/L (low Apo A-I group) and those with Apo A-I > 1.19 g/L (high Apo A-I group). OS and CSS were estimated by Kaplan–Meier analysis and the log-rank test was used to compare differences between groups. Univariate and multivariate Cox regression analyses were plotted to assess the prognostic value of Apo A-I in NMIBC patients. In addition, subgroup analyses were performed according to the risk classification of the International Bladder Cancer Group.ResultsIn the overall population, patients in the high Apo A-I group had greater 5-year OS and 5-year CSS rates as compared to those in the low Apo A-I group. Kaplan–Meier survival analysis revealed that higher albumin, Apo A-I, and hemoglobin levels were associated with greater OS and CSS while elevated neutrophil–lymphocyte ratio was associated with worse OS and CSS in the overall and high-risk population rather than low- and intermediate-risk population. Furthermore, Apo A-I was shown to be an independent predictor in the overall population (for OS, hazard ratio [HR], 0.364, 95% confidence interval [CI], 0.221–0.598, p < 0.001; for CSS, HR, 0.328, 95% CI, 0.185–0.583, p < 0.001) and high-risk patients (for OS, HR, 0.232, 95% CI 0.121–0.443, p < 0.001; for CSS, HR, 0.269, 95% CI, 0.133–0.541, p < 0.001).ConclusionThese results suggest that Apo A-I level could potentially serve as a useful prognostic indicator for therapeutic decision making in NMIBC patients.

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Prognostic scores based on the preoperative plasma fibrinogen and serum albumin level as a prognostic factor in patients with upper urinary tract urothelial carcinoma

Cited by 12 publications

References 29 publications

<p>Prognostic Value of Cumulative Score Based on Preoperative Fibrinogen and Albumin Level in Skull Base Chordoma</p>

<p>Prognostic Value of Cumulative Score Based on Preoperative Fibrinogen and Albumin Level in Skull Base Chordoma</p>

Prognostic value of plasma fibrinogen in hepatocellular carcinoma: a meta-analysis

Preoperative serum apolipoprotein A-I levels predict long-term survival in non-muscle-invasive bladder cancer patients

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Prognostic scores based on the preoperative plasma fibrinogen and serum albumin level as a prognostic factor in patients with upper urinary tract urothelial carcinoma

Cited by 12 publications

References 29 publications

<p>Prognostic Value of Cumulative Score Based on Preoperative Fibrinogen and Albumin Level in Skull Base Chordoma</p>

<p>Prognostic Value of Cumulative Score Based on Preoperative Fibrinogen and Albumin Level in Skull Base Chordoma</p>

Prognostic value of plasma fibrinogen in hepatocellular carcinoma: a meta-analysis

Preoperative serum&nbsp;apolipoprotein A-I levels predict long-term survival in non-muscle-invasive bladder cancer patients

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Preoperative serum apolipoprotein A-I levels predict long-term survival in non-muscle-invasive bladder cancer patients