Prognostic role of tumor mutation burden in hepatocellular carcinoma after radical hepatectomy

Abstract

Background and Aim This study aimed to assess the potential relationship between tumor mutation burden (TMB) and the recurrence risk of hepatocellular cancer (HCC) after curative resection and tried to develop a reliable TMB based nomogram. Methods This retrospective study was conducted in 128 patients (40 patients suffered from a recurrence of HCC) who had received radical hepatectomy by the same surgical team. A nomogram model was constructed using the R and EmpowerStats software. Results TMB was not associated with maximum tumor size and the presence of microvascular invasion (MVI). In the whole population or subgroups, the recurrence‐free survival (RFS) rate was significantly lower in the TMB high group. In multivariate analysis, TMB (hazard ratio [HR], 10.12; 95% confidence interval [CI], 5.03‐20.31; P < .001), large tumor diameter (HR, 2.91; 95% CI, 1.51‐5.63; P = .001), presence of MVI (HR, 1.93; 95% CI, 1.03‐3.65; P = .042) were independent predictors of RFS. The predictive power of the nomogram integrating TMB, tumor size and MVI was higher than model only incorporating tumor size and MVI. Conclusion This study demonstrated for the first time that higher TMB was associated with poor prognosis in patients with HCC who had received curative resection, and a TMB based nomogram model had a well predictive performance for RFS in this population.

Identification of the Real Hub Gene and Construction of a Novel Prognostic Signature for Pancreatic Adenocarcinoma Based on the Weighted Gene Co-expression Network Analysis and Least Absolute Shrinkage and Selection Operator Algorithms

“…Therefore, the high mutation frequency of genes is associated with improved immunotherapy responses, long-lasting clinical benefits, and progression-free survival ( Rizvi et al, 2015 ). In 2020, Cai et al (2020) reported that higher mutation frequency was closely associated with the poorer clinical outcomes of patients with hepatocellular carcinoma. Likewise, our data indicated that patients with PAAD in the high-risk subgroup with high gene mutation frequency had worse prognoses.…”

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“…In this study, with the help of X-title software analysis, we found that when the TMB = 4.2 was used as the boundary between a high and low TMB, the difference in prognosis between the two groups was the greatest. HCC patients with high TMB had a poor prognosis, and these results are consistent with the conclusion of Cai et al (2020). More interestingly, TMB = 4.2 was used as a cutoff, and the highand low-TMB groups exhibited an obvious difference regarding immune cell infiltration.…”

Comprehensive Analysis of Genomic Mutation Signature and Tumor Mutation Burden for Prognosis of Intrahepatic Cholangiocarcinoma

“…Owada-Ozaki et al from Japan found that higher TMB was correlated with shorter disease-free survival in NSCLC patients [33]. A study from China demonstrated that in HCC patients who had received radical resection, patients with higher TMB tend to have higher recurrence risk rate, and it was an independent risk factors of RFS [34]. We identi ed the median number of TMB in iCCAs was 1.25 (range 0.03-54.74).…”