Prognostic role of the long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 in various cancers: A meta-analysis

Yan, Ji; Zhou, Xiaoying; Dang, Yini; Yin, Chengqiang; Zhang, Guoxin

doi:10.3892/mco.2015.657

Cited by 6 publications

(6 citation statements)

References 40 publications

(47 reference statements)

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“…MALAT1 is involved with the survival of various tumor types and may act as a valid prognostic biomarker for cancer ( 34 ). A previous study revealed its role in extensive biological processes.…”

Section: Discussionmentioning

confidence: 99%

Cognitive improvement following ischemia/reperfusion injury induced by voluntary running‑wheel exercise is associated with LncMALAT1‑mediated apoptosis inhibition

et al. 2018

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Previous human and animal studies demonstrated that voluntary exercise may improve cognitive function and facilitate neuronal plasticity in ischemia/reperfusion (I/R) models. However, the possible underlying mechanisms remain to be elucidated. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long noncoding RNA (lncRNA), may be associated with the functions and dysfunctions of endothelial cells. The present study investigated whether spontaneous running-wheel (RW) exercise-induced MALAT1 expression changes may be associated with the cognitive improvement of mice following I/R injury. The expression of MALAT1 was evaluated using reverse transcription-quantitative polymerase chain reaction. Artificial MALAT1 and MALAT1 lentiviral mall interfering (siRNA) were used to alter MALAT1 expression levels in vivo. The Morris Water Maze test was performed to evaluate spatial learning and memory retention in the mice. Changes in the apoptotic rates of hippocampal neurons and levels of apoptosis-associated proteins were also detected. The data revealed that MALAT1 increased in the hippocampus of mice in the RW-treated I/R group and that this was associated with neurological, learning and memory improvement, reduced infarction volumes, decreased apoptosis and alterations to expression levels of apoptosis-associated proteins. Following RW training in I/R-injured mice, lentiviral MALAT1 siRNA conduction partially attenuated the protections induced by voluntary RW. However, exogenous MALAT1 treatment increased the protection. The current findings suggested that voluntary RW protected hippocampal neurons from I/R injury and promoted cognitive restoration, which was associated with lncRNA MALAT1-mediated apoptosis inhibition.

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Section: Discussionmentioning

confidence: 99%

Cognitive improvement following ischemia/reperfusion injury induced by voluntary running‑wheel exercise is associated with LncMALAT1‑mediated apoptosis inhibition

et al. 2018

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“…Additional published studies on MALAT1 in UC are difficult to compare as only small sample numbers were investigated and information on histopathological characteristics is not comprehensive [ 26 ]. Two meta-analyses of 10 studies on MALAT1 in various cancer types indicated a relatively consistent association of increased MALAT1 expression with survival in various types of cancer, but some studies analysed only few cases [ 36 , 37 ]. Clearly, further studies on MALAT1 should be conducted to ascertain the association of its expression with tumour subtypes.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and prognostic value of long noncoding RNAs as biomarkers in urothelial carcinoma

Droop¹,

Szarvas²,

Schulz³

et al. 2017

PLoS ONE

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Many long noncoding RNAs (lncRNAs) are deregulated in cancer and contribute to oncogenesis. In urothelial carcinoma (UC), several lncRNAs have been reported to be overexpressed and proposed as biomarkers. As most reports have not been confirmed independently in large tissue sets, we aimed to validate the diagnostic and prognostic value of lncRNA upregulation in independent cohorts of UC patients. Thus, expression of seven lncRNA candidates (GAS5, H19, linc-UBC1, MALAT1, ncRAN, TUG1, UCA1) was measured by RT-qPCR in cell lines and tissues and correlated to clinicopathological parameters including follow-up data (set 1: N n = 10; T n = 106). Additionally, publicly available TCGA data was investigated for differential expression in UC tissues (set 2: N n = 19; T n = 252,) and correlation to overall survival (OS). All proposed candidates tended to be upregulated in tumour tissues, with the exception of MALAT1, which was rather diminished in cancer tissues of both data sets. However, strong overexpression was generally limited to individual tumour tissues and statistically significant overexpression was only observed for UCA1, TUG1, ncRAN and linc-UBC1 in tissue set 2, but for no candidate in set 1. Altered expression of individual lncRNAs was associated with overall survival, but not consistently between both patient cohorts. Interestingly, lower expression of TUG1 in a subset of UC patients with muscle-invasive tumours was significantly correlated with worse OS in both cohorts. Further analysis revealed that tumours with low TUG1 expression are characterized by a basal-squamous-like subtype signature accounting for the association with poor outcome. In conclusion, our study demonstrates that overexpression of the candidate lncRNAs is found in many UC cases, but does not occur consistently and strongly enough to provide reliable diagnostic or prognostic value as an individual biomarker. Subtype-dependent expression patterns of lncRNAs like TUG1 could become useful to stratify patients by molecular subtype, thus aiding personalized treatments.

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“…[4–6] Moreover, aberrant lncRNA expression was found to lead to metastasis and cancer progression. [7–9] The lncRNAs such as urothelial cancer associated 1 (UCA1), [10] metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), [11] H19, [12] and PVT1 [13] were found to predict lymph node metastasis (LNM) and a poor prognosis in human cancers. Recently, the lncRNA small nucleolar RNA host gene 1 (SNHG1) was found to be high-expressed and functioned as an oncogene in various cancers, such as nonsmall-cell lung cancer, [14] gastric cancer, [15] and colorectal cancer.…”

Section: Introductionmentioning

confidence: 99%

Upregulation of lncRNA SNHG1 is associated with metastasis and poor prognosis in cancers

Yan

Hua

et al. 2019

Medicine

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Background: Accumulating evidence suggested that the expression level of long noncoding RNA small nucleolar RNA host gene 1 (lncRNA SNHG1) was upregulated in various cancers, and high expression of SNHG1 was associated with metastasis and prognosis in patients with cancer. The relationship between SNHG1 expression and metastasis or prognosis in malignant tumors was investigated in this meta-analysis. Methods: A systematic search was performed in PubMed, Web of Science, and Cochrane Library from inception until May 31, 2018. Hazard ratio (HR) or odds ratio (OR) with 95% confidence intervals (95% CIs) were calculated to demonstrate prognostic value of SNHG1 using Stata 12.0 software. Results: A total of 10 studies including 1129 patients were finally enrolled in the meta-analysis based on the inclusion and exclusion criteria. Increased SNHG1 expression was significantly associated with lymph node metastasis (OR = 3.28, 95% CI = 2.02–5.33) and advanced TNM stage (OR = 0.26, 95% CI = 0.16–0.43). Moreover, high expression of SNHG1 could predict poor overall survival (HR = 2.32, 95% CI = 1.90–2.83), event-free survival (HR = 1.58, 95% CI = 1.06–2.35), recurrence-free survival (HR = 2.15, 95% CI = 1.23–3.77), progression-free survival (HR = 2.75, 95% CI = 1.70–4.46), and disease-free survival (HR = 1.93, 95% CI = 1.10–3.40) in patients with cancer. Conclusion: The present meta-analysis demonstrated that upregulation of lncRNA SNHG1 might serve as a useful prognostic biomarker in various cancers.

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Prognostic role of the long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 in various cancers: A meta-analysis

Cited by 6 publications

References 40 publications

Cognitive improvement following ischemia/reperfusion injury induced by voluntary running‑wheel exercise is associated with LncMALAT1‑mediated apoptosis inhibition

Cognitive improvement following ischemia/reperfusion injury induced by voluntary running‑wheel exercise is associated with LncMALAT1‑mediated apoptosis inhibition

Diagnostic and prognostic value of long noncoding RNAs as biomarkers in urothelial carcinoma

Upregulation of lncRNA SNHG1 is associated with metastasis and poor prognosis in cancers

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