Prognostic Role of Simplified Pulmonary Embolism Severity Index and the European Society of Cardiology Prognostic Model on Short- and Long-term Risk Stratification in Pulmonary Embolism.

Kılıç, Talat; Günen, Hakan; Gülbaş, Gazi; Hacievlıyagıl, Süleyman Savaş; Özer, Ali

doi:10.12669/pjms.306.5737

Cited by 13 publications

(15 citation statements)

References 26 publications

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“…Also, higher sPESI score, high and intermediate-high estimated risk are confirmed as predictors of the 30-day mortality and NACO, which is consistent with the literature data [23][24][25] .…”

Section: Discussionsupporting

confidence: 91%

The significance of C-reactive protein for the prediction of net-adverse clinical outcome in patients with acute pulmonary embolism

et al. 2020

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Background/Aim. Acute pulmonary embolism (APE) may have different clinical manifestations. Also, its outcome can range from complete recovery to early death. Major bleeding (MB) as a due of the therapy also contributes to the overall adverse outcome. So far, it is unknown what the best predictors are for short-term mortality and MB among the several commonly used biomarkers. The aim of this study was to evaluate the significance of Creactive protein (CRP) and other biomarkers for the prediction of adverse clinical outcomes. Methods. This clinical, observational, retrospective-prospective study included 219 consecutive adult patients treated for APE. Results. Among 219 patients, 22 (10%) died within the first month after diagnosis. Twenty seven patients (12.3%) had at least one episode of MB. Composite end-point [netadverse clinical outcome (NACO)] was estimated in 47 (21.5%) of patients. The average values of all biomarkers were higher in the group of patient who died, and differences were statistically significant. Similar results were obtained for composite end-point. In terms of MB, none of biomarkers did not have significance, but CRP had a slight tendency toward significance. Results from univariate logistic regression model showed that troponin was statistically significant predictor of 30-day mortality. However, after adjusting for other variables, in multivariate logistic regression model troponin failed to be significant independent predictor of 30-day mortality. Unlike troponin, CRP and brain natriuretic peptide (BNP) were significant in all models-uni and multivariate (they were independent predictors of 30-day mortality). Conclusion. CRP has a good predictive value for 30-day mortality and NACO, and potential for MB in patients treated for APE.

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Section: Discussionsupporting

confidence: 91%

The significance of C-reactive protein for the prediction of net-adverse clinical outcome in patients with acute pulmonary embolism

et al. 2020

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“…Our baseline characteristics and patient comorbidities are quite similar to other studies [7] with heart failure, chronic pulmonary disease and obesity being the most frequent associated comorbidities. We note that although the outright proportion of obese patients is lower, the mean Table 1 SUMMARY OF BASELINE CHARACTERISTICS BMI was about 28kg/m 2 which is consistent with overweight patients.…”

Section: Resultssupporting

confidence: 82%

Clinical and Laboratory Aspects of the Severity of Pulmonary Embolism in Elderly Patients versus Adult Patients A single centre study

Morgovan¹,

Ivan²,

Buzas³

et al. 2019

Rev.Chim.

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Pulmonary thromboembolism is currently one of the leading causes of disease burden and mortality in Europe, also known as the great masquerader, for its ability to mimic other diseases or to present itself with few symptoms, especially when the pulmonary embolism is very small. With aging population, increased survival of cancer patients and the addition of multiple debilitating diseases such as dementia, heart failure, chronic kidney disease the rate of pulmonary embolism is spiking, with more and more small pulmonary embolism being diagnosed, that may have no immediate impact on mortality, but which may contribute to an increase in morbidity. We have examined retrospectively 108 consecutively cases of pulmonary thromboembolism that have presented in the Emergency Department of Municipal Hospital in Timisoara, Romania over the course of twenty-one months from September 2016 to May 2018 and we evaluated the clinical and laboratory findings in studying the influence of age over the severity of pulmonary embolism.

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“…In the study conducted by Tamizifar et al it was stated that sPESI score accurately predicted the mortality rate for low-risk patients, but could not predict prognosis significantly in high-risk patients [24]. Kılıç et al's study indicated that sPESI was significant in determining mortality for PE in the short and long term, and that no additional laboratory and imaging tests were required at low sPESI values [25]. In our study, the sPESI score was found to be high in only quantitative d-dimer negative cases.…”

Section: Discussionmentioning

confidence: 99%

Comparison of normal D-dimer in different category in patient with pulmonary embolism

2020

Ann Clin Anal Med

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Aim: Quantitative D-dimer is used to exclude pulmonary embolism in patients with low clinical probability. In this study, we aimed to compare quantitative ddimer, age-adjusted D-dimer, and age-adjusted D-dimer suggested by the American College of Emergency Physicians (ACEP). Materials and Methods: Emergency service patients above the age of 18, whose D-dimer values were tested due to the suspicion of pulmonary thromboembolism were evaluated retrospectively. Quantitative d-dimer level, age-adjusted D-dimer, and age-adjusted D-dimer suggested by the ACEP levels were compared with patient data. SPSS (Statistical Package for Social Sciences) Windows 20.0 software was used for statistical analysis of all data obtained. Results: Three different categories of D-dimer values were compared. According to ACEP, the D-dimer value skipped the least number of PE diagnosis compared to the other values and it was found to be the most significant in determining PE. sPESI was not significant in predicting mortality in PE patients. Discussion: D-Dimer values vary according to the devices and kits used. Today, D-dimer values are used in many clinics to exclude PE. These include the quantitative d-dimer, age-adjusted d-dimer, and the age-adjusted d-dimer suggested by ACEP. It is identified that the cut-off value of d-dimer, calculated according to age, reduced the need for imaging tests significantly compared to quantitative d-dimer. A systemic meta-analysis found that the d-dimer test results calculated for age reduced the need for imaging by 5% compared to normal d-dimer test results when combined with Wells score. Conclusion: Recommended by ACEP age-adjusted D-Dimer may be preferred for the evaluation of pulmonary embolism patients.

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Prognostic Role of Simplified Pulmonary Embolism Severity Index and the European Society of Cardiology Prognostic Model on Short- and Long-term Risk Stratification in Pulmonary Embolism.

Cited by 13 publications

References 26 publications

The significance of C-reactive protein for the prediction of net-adverse clinical outcome in patients with acute pulmonary embolism

The significance of C-reactive protein for the prediction of net-adverse clinical outcome in patients with acute pulmonary embolism

Clinical and Laboratory Aspects of the Severity of Pulmonary Embolism in Elderly Patients versus Adult Patients A single centre study

Comparison of normal D-dimer in different category in patient with pulmonary embolism

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