Prognostic Role of Serum Uric Acid in Critically Ill Patients with Non-ST Elevation Acute Myocardial Infarction

Kv, Charan Reddy; Ghanekar, Jaishree

doi:10.18281/jcvd.2015.3.2

Cited by 1 publication

(1 citation statement)

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“…Moreover, Baruah et al also reported a high serum uric acid level in patients with AMI (Baruah et al, 2012;Bonora et al, 1996) study with 957 young men and Sokhanvar et al proved the positive relationship between hyperuricemia and MI (Sokhanvar and Maleki, 2007). Elevated uric acid is associated with increased xanthine oxidase activity (Reddy and Ghanekar, 2015). The oxygen-free radicals generated during uric acid synthesis are a useful indicator of excess oxidative stress, which is involved in the no-re low phenomenon during reperfusion therapy.…”

Section: Resultsmentioning

confidence: 99%

Uric acid as a biomarker in acute myocardial infarction

Merriwin

Lakshmi²,

Rajan

2020

ijrps

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Acute Myocardial Infarction (AMI) is a global threat to health, particularly for developing countries. Every year about 17 million of the world population die of cardiovascular disease. The activity of the enzyme xanthine oxidase and the oxidative stress level is reflected by the levels of serum uric acid. Uric acid, an independent marker in populations with AMI has been shown to reflect the short and long term adverse cardiac outcomes. Elevated uric acid levels are associated with reduced glomerular filtration rate, hypertension, arterial stiffness, cardiac hypertrophy and heart failure. There exists a five to six-fold rise in uric acid concentration in atherosclerotic patients. The mortality index in patients with cardiovascular disease can be predicted by high uric acid levels. The aim of our study was to correlate the increased uric acid levels with the severity and prognosis in myocardial infarction patients. Our study included 55 patients with AMI, including both ST-segment elevation myocardial infarction (STEMI) and non-ST segment elevation myocardial infarction (NSTEMI), in whom serum uric acid was measured. The results were analyzed using the Statistical Package of Social Sciences (SPSS) software. A statistically significant (p <0.001) increase in the serum uric acid levels were noted in the patients diagnosed with Myocardial Infarction (MI). The increase in uric acid levels helps to predict mortality in acute MI patients.

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Section: Resultsmentioning

confidence: 99%