Prognostic role of serum carbohydrate antigen 19-9 levels in patients with resectable hepatocellular carcinoma

Abstract

Serum levels of carbohydrate antigen 19-9 (CA 19-9) were shown to be associated with poorer prognosis in several cancers, but the prognostic role of CA 19-9 levels in patients with hepatocellular carcinoma was unclear. A retrospective cohort of 97 patients with resectable hepatocellular carcinoma was performed to assess the prognostic role of CA 19-9 levels on overall survival in hepatocellular carcinoma. Both Kaplan-Meier product-limit method and multivariate analysis were performed to determine the prognostic role of CA 19-9 levels. The results indicated that among those 97 patients, 24 (24.7%) had elevated preoperative CA 19-9 levels (≥37 U/mL). Elevated serum CA 19-9 levels did not correlate with patient age, gender, tumor size, tumor stage, diabetes, and hepatitis B virus (HBV) infection. Kaplan-Meier product-limit method showed that patients with elevated CA 19-9 levels had poorer survival than those with normal CA 19-9 levels (log-rank test P < 0.001). Multivariate analysis showed that elevated CA 19-9 level was a significantly independent predictor of poorer overall survival (hazard ratio [HR] = 2.56; 95% confidence interval [95% CI] 1.41-4.64, P = 0.002). In addition, tumor stages and multiple tumors were also independent predictors of poorer overall survival in hepatocellular carcinoma (P < 0.01). In conclusion, serum CA 19-9 levels have an independent prognostic role in patients with resectable hepatocellular carcinoma. Elevated CA 19-9 level is significantly associated with poorer overall survival in hepatocellular carcinoma.

Carbohydrate Antigen 19-9 Increases the Predictive Efficiency of a-Fetoprotein for Prognosis of Resected Hepatocellular Carcinoma

“…12,13 Therefore, novel promising candidates, single or in combination with AFP, need to be accumulated. During recent years, CA19-9 and CEA were revealed to be prognostic in HCC after different treatments [18][19][20][21][22] but less focused on patients after hepatectomy. 18,21 Among them, AFP was not included as an assessed variable by some authors.…”

“…During recent years, CA19-9 and CEA were revealed to be prognostic in HCC after different treatments [18][19][20][21][22] but less focused on patients after hepatectomy. 18,21 Among them, AFP was not included as an assessed variable by some authors. 21 In fact, combined evaluation of these markers and AFP was not performed in resected patients.…”

“…16,17 Recently, some investigations revealed that these two proteins carried prognostic implication in HCC after different managements. [18][19][20][21][22] Of them, only two focused on patients after surgical resection. 18,21 Furthermore, combination of these markers and a conventional one, AFP, similar with that for individuals with liver transplantation, 19 was not attempted in resected series.…”

“…[18][19][20][21][22] Of them, only two focused on patients after surgical resection. 18,21 Furthermore, combination of these markers and a conventional one, AFP, similar with that for individuals with liver transplantation, 19 was not attempted in resected series. In the present study, the authors aimed to evaluate the prognostic value of single and combined tumor markers in HCC after radical hepatectomy.…”

Lateral flow assay for carbohydrate antigen 19–9 in whole blood by using magnetized carbon nanotubes

“…CA 19-9 is a well-established biomarker for pancreatic carcinoma, and has also been reported to be positive in other types of gastrointestinal cancers including gastric cancer, cholangiocarcinoma and colorectal cancer [2]. The level of CA 19-9 is also of great value for envisaging the prognosis of the disease, estimating the severity of the disease and predicting recurrence.…”