Prognostic role of pretreatment red blood cell distribution width in patients with cancer: A meta-analysis of 49 studies

Wang, Pengfei; Song, Shu; Guo, Hang; Wang, Tingjian; Liu, Ning; Chen, Yan

doi:10.7150/jca.31598

Cited by 59 publications

(57 citation statements)

References 96 publications

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“…This phenomenon will eventually lead to variations in the sizes of the red blood cells involved in the circulatory response in the peripheral blood, as manifested by increased RDW levels [25]. Moreover, the increase in RDW may be related to oxidative stress response in the body [26]. Red blood cells, the most important oxygen-carrying medium in the body, will induce hypoxia or a hypoxic microenvironment when they differ in size or their functions are impaired.…”

Section: Plos Onementioning

confidence: 99%

The value of red blood cell distribution width, neutrophil-to-lymphocyte ratio, and hemoglobin-to-red blood cell distribution width ratio in the progression of non-small cell lung cancer

Chen

et al. 2020

PLoS ONE

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Background Lung cancer is the leading cause of cancer-related deaths worldwide, with non-small cell lung cancer (NSCLC) accounting for 85% of all lung cancer cases. Inflammation has been proven to be one of the characteristics of malignant tumors. Chronic inflammatory response mediated by cytokines in the tumor microenvironment is an important factor in tumorigenesis. The purpose of this study was to observe and evaluate the value of red blood cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), and hemoglobin-to-red blood cell distribution width ratio (HRR) in the progression of NSCLC. Methods A total of 245 patients with NSCLC, 97 patients with benign pulmonary nodules, and 94 healthy volunteers were included in this study. Factors, such as age, gender, smoking history, histological type, lymph node metastasis, distant metastasis, TNM stage, and differentiation degree were statistically analyzed. The correlation of RDW, NLR, and HRR of patients with NSCLC with other clinical experimental parameters were also analyzed. Then, the diagnostic value of RDW, NLR, and HRR in the progression of NSCLC was evaluated. Results RDW, NLR, and HRR could be used to distinguish patients with NSCLC from healthy controls (p < 0.05). In addition, only the RDW in the NSCLC group with III-IV stage was significantly different from that in the benign pulmonary nodules group (p = 0.033), while NLR and

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Section: Plos Onementioning

confidence: 99%

The value of red blood cell distribution width, neutrophil-to-lymphocyte ratio, and hemoglobin-to-red blood cell distribution width ratio in the progression of non-small cell lung cancer

Chen

et al. 2020

PLoS ONE

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“…It is largely accepted that multiple forms of pathologies, both related to abnormal structure RBC membrane or cytosolic proteins and lipids, as well as systemic disorders such as cancer, diabetes, cardiovascular diseases, sepsis and other diseases of inflammation are associated with anemia, RBC damage and their premature removal from the circulation and increase in their heterogeneity (e.g., Salvagno et al, 2015;Feng et al, 2017;Ahmad et al, 2018;Ko et al, 2018;Yin et al, 2018;Parizadeh et al, 2019;Wang et al, 2019). The causes and consequences as well as predictive power of this increase in variability of RBC properties is out of the scope of this review but deserve special attention.…”

Section: Physical Activity High Altitude and Other Stress Conditionsmentioning

confidence: 99%

Heterogeneity of Red Blood Cells: Causes and Consequences

et al. 2020

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Mean values of hematological parameters are currently used in the clinical laboratory settings to characterize red blood cell properties. Those include red blood cell indices, osmotic fragility test, eosin 5-maleimide (EMA) test, and deformability assessment using ektacytometry to name a few. Diagnosis of hereditary red blood cell disorders is complemented by identification of mutations in distinct genes that are recognized "molecular causes of disease." The power of these measurements is clinically wellestablished. However, the evidence is growing that the available information is not enough to understand the determinants of severity of diseases and heterogeneity in manifestation of pathologies such as hereditary hemolytic anemias. This review focuses on an alternative approach to assess red blood cell properties based on heterogeneity of red blood cells and characterization of fractions of cells with similar properties such as density, hydration, membrane loss, redox state, Ca 2+ levels, and morphology. Methodological approaches to detect variance of red blood cell properties will be presented. Causes of red blood cell heterogeneity include cell age, environmental stress as well as shear and metabolic stress, and multiple other factors. Heterogeneity of red blood cell properties is also promoted by pathological conditions that are not limited to the red blood cells disorders, but inflammatory state, metabolic diseases and cancer. Therapeutic interventions such as splenectomy and transfusion as well as drug administration also impact the variance in red blood cell properties. Based on the overview of the studies in this area, the possible applications of heterogeneity in red blood cell properties as prognostic and diagnostic marker commenting on the power and selectivity of such markers are discussed.

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“…Increase in RDW values have been suggested as a diagnostic and prognostic tool in colon cancer patients (16,17). Very recently, in a meta-analysis of 49 studies, elevated pretreatment RDW level was suggested as a negative predictor for cancer prognosis (18). We determined a significant increase in RDW values after chemotherapy which may be associated with increased inflammatory response.…”

Section: Discussionmentioning

confidence: 96%

ASSESSMENT of HEMATOLOGICAL PARAMETERS BEFORE and AFTER ADJUVANT CHEMOTHERAPY in PATIENTS with COLORECTAL CANCER

Kasapoğlu¹,

Yozgat²,

Engın³

2019

Acta Oncol Tur.

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Bu çalışmada kolorektal kanserli hastalarda adjuvan kemoterapi tedavisi sonrasında hematolojik parametrelerdeki değişiklikleri değerlendirmeyi amaçladık. YÖNTEM ve GEREÇLER: Kolorektal kanser tanısı konan toplam 140 vakada değerlendirilmiş ve bu hastalardan 57'sine adjuvan kemoterapi verilmiştir. Adjuvan kemoterapi sonrası tam kan sayımı parametrelerindeki değişiklikler değerlendirildi. BULGULAR: Katılımcıların 67'si (% 47.9) kadın, 73'ü (% 52.1) erkek idi, yaş ortalamaları 62.13 ± 1.11 yıl idi. En sık görülen tümör yerleşimi rektumdu (% 45.7). Bu hastalardan 57'si adjuvan kemoterapi (% 40.7) aldı, en sık uygulanan kemoterapi rejimi Mayo rejimi (% 84.2) idi. Olgularımızın % 27.9'unda tanı anında metastaz vardı. Klinik takip sırasında hastaların% 10.7'sinde lokal nüks ve% 7.8'inde metastaz vardı. Hemoglobin (HGB) düzeyleri hem kan transfüzyonu yapılan hastalarda hem de yapılmayanlarda anlamlı bir düşüş gösterdi, ancak bu daha önce transfüzyonu olmayan hasta grubunda daha belirgindi (p = 0.002). Yardımcı kemoterapiyi takiben, beyaz kan hücresi değerleri (WBC), ortalama eritrosit hacimleri (MCV) ve trombosit (PLT) seviyelerinin, modifiye edici bileşenlerle (metastaz gelişimi, kemoterapi uygulama süresi, kan transfüzyonu) herhangi bir etkileşim olmadan önemli ölçüde azaldığı bulundu. (Sırasıyla p değerleri 0.002, 0.001 ve 0.001), ayrıca kırmızı hücre dağılım genişliği (RDW) önemli ölçüde artmıştır (p = 0.001). TARTIŞMA ve SONUÇ: Hgb, MCV, WBC ve trombosit seviyelerinde anlamlı bir azalma ve adjuvan kemoterapi sonrası RDW'de anlamlı bir artış vardı ve bu değişiklikler metastaz varlığından veya kemoterapi süresinden etkilenmedi. Kan parametrelerinde bu değişikliklerin hastaların prognozu ile ilişkisi ileriki çalışmalarda araştırılmalıdır. Anahtar Kelimeler: kolorektal kanser, beyaz kan hücresi değerleri, ortalama eritrosit hacmi, trombosit, kırmızı hücre dağılım genişliği ABSTRACT INTRODUCTION: In this study we aimed to evaluate the alterations in hematological parameters due to the adjuvant chemotherapy treatment in patients with colorectal cancer. METHODS: In a total of 140 cases diagnosed with colorectal cancer were evaluated and among those patients 57 received adjuvant chemotherapy. Alterations in complete blood count parameters after adjuvant chemotherapy were evaluated. RESULTS: Among participants, 67 (47.9%) were women and 73 (52.1%) were men with a mean age of 62.13 ± 1.11 years. The most common tumor localization was rectum (45.7%). Among these patients 57 received adjuvant chemotherapy (40.7%), the most frequently implemented chemotherapy regimen was Mayo regimen (84.2%). 27.9% of our cases had metastasis at the time of diagnosis. During clinical follow-up 10.7% of the patients had local relapse and 7.8% had metastasis. Hemoglobin (HGB) levels displayed a significant decrease both in patients who received blood transfusion or not, however this was more evident in the group of patients

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Prognostic role of pretreatment red blood cell distribution width in patients with cancer: A meta-analysis of 49 studies

Cited by 59 publications

References 96 publications

The value of red blood cell distribution width, neutrophil-to-lymphocyte ratio, and hemoglobin-to-red blood cell distribution width ratio in the progression of non-small cell lung cancer

The value of red blood cell distribution width, neutrophil-to-lymphocyte ratio, and hemoglobin-to-red blood cell distribution width ratio in the progression of non-small cell lung cancer

Heterogeneity of Red Blood Cells: Causes and Consequences

ASSESSMENT of HEMATOLOGICAL PARAMETERS BEFORE and AFTER ADJUVANT CHEMOTHERAPY in PATIENTS with COLORECTAL CANCER

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