Prognostic Role of Preoperative Onodera’s Prognostic Nutritional Index (OPNI) in Gastrointestinal Stromal Tumors: a Systematic Review and Meta-analysis

Ren, Wei; Xiang, Tian; Liu, Gao

doi:10.1007/s12029-022-00878-0

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…However, without exception, these studies were performed in patients who underwent curative GIST resection. Of note, in almost all studies, the PNI has repeatedly been an independent prognostic factor, as also demonstrated in several meta-analyses, including in patients receiving or not receiving tyrosine kinase inhibitors [30][31][32].…”

Section: Discussionmentioning

confidence: 60%

Prognostic Nutritional Index is a valuable prognostic marker in Mexican patients operated on and not on gastrointestinal stromal tumors. A retrospective cohort study

Herrera-Goepfert,

Soca-Chafre,

Oñate-Ocaña

et al. 2024

Preprint

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Purpose. The immune-nutritional status of patients with cancer has a profound impact on their lifespan. The Prognostic Nutritional Index (PNI) has been used to evaluate, among others, the prognosis in operated patients harboring neoplastic as well as non-neoplastic conditions. This study estimates the survival of Mexican patients suffering from gastrointestinal stromal tumors (GIST) operated on or not based on PNI. Methods. The immune-nutritional status was retrospectively analyzed in a cohort of 146 patients with GIST. Receiver operating characteristic (ROC) curves were used to estimate optimal cutoff point and to predict overall survival (OS) for prognostic nutritional index (PNI). Survival curves were obtained with the Kaplan-Meier method and log-rank tests. A Multivariate analysis of survival was performed with Cox regression. Results. PNI cutoff was 36.5 and the only independent prognostic score (0.007); the PNI-high group had better survival (p = 0.001). High PNI was correlated with surgical intervention and low mitotic index. Conclusions. PNI < 36.5 entails a worse prognosis for Mexican patients suffering from GIST. PNI has a high ability to predict survival, even in patients for whom surgery is not a feasible option. The PNI is a simple and reliable calculation tool, as well as an inexpensive, reproducible, and powerful factor to predict patient prognosis, besides the pathological approach.

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Section: Discussionmentioning

confidence: 60%

Prognostic Nutritional Index is a valuable prognostic marker in Mexican patients operated on and not on gastrointestinal stromal tumors. A retrospective cohort study

Herrera-Goepfert,

Soca-Chafre,

Oñate-Ocaña

et al. 2024

Preprint

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The predictive value of serum NLR, SII, and OPNI for lymph node metastasis in breast cancer patients with internal mammary lymph nodes after thoracoscopic surgery

Li,

Fei

2024

Open Life Sciences

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In this research, we delved into the predictive potential of three key markers – the neutrophil-to-lymphocyte ratio (NLR), systemic immune inflammation index (SII), and Onodera’s prognostic nutritional index (OPNI), in assessing lymph node metastases in breast cancer patients who had internal mammary lymph node involvement following thoracoscopic surgery. Our study revealed notable pathological distinctions between the groups with and without metastases, while age, tumor size, and histological grade exhibited no significant differences. The analysis unveiled statistically significant variances in NLR, SII, and OPNI when comparing these two groups. Multivariate analysis pinpointed NLR (OR = 1.503), SII (OR = 1.987), and OPNI (OR = 0.612) as robust predictors of lymph node metastases. Remarkably, combining these markers (AUC: 0.897) substantially enhanced the precision of predicting lymph node metastases compared to individual measurements (NLR: 0.749, SII: 0.717, and OPNI: 0.787). In conclusion, this study underscores the pivotal role of NLR, SII, and OPNI in predicting lymph node metastasis among breast cancer patients with internal mammary lymph node involvement post-thoracoscopic surgery, affirming our utility as reliable independent predictors of this critical clinical outcome.

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Interpretations of the Role of Plasma Albumin in Prognostic Indices: A Literature Review

Gradel

2023

JCM

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This review assesses how publications interpret factors that influence the serum or plasma albumin (PA) level in prognostic indices, focusing on inflammation and nutrition. On PubMed, a search for “albumin AND prognosis” yielded 23,919 results. From these records, prognostic indices were retrieved, and their names were used as search strings on PubMed. Indices found in 10 or more original research articles were included. The same search strings, restricted to “Review” or “Systematic review”, retrieved yielded on the indices. The data comprised the 10 latest original research articles and up to 10 of the latest reviews. Thirty indices had 294 original research articles (6 covering two indices) and 131 reviews, most of which were from recent years. A total of 106 articles related the PA level to inflammation, and 136 related the PA level to nutrition. For the reviews, the equivalent numbers were 54 and 65. In conclusion, more publications mention the PA level as a marker of nutrition rather than inflammation. This is in contrast to several general reviews on albumin and nutritional guidelines, which state that the PA level is a marker of inflammation but not nutrition. Hypoalbuminemia should prompt clinicians to focus on the inflammatory aspects in their patients.

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Prognostic Role of Preoperative Onodera’s Prognostic Nutritional Index (OPNI) in Gastrointestinal Stromal Tumors: a Systematic Review and Meta-analysis

Cited by 3 publications

References 30 publications

Prognostic Nutritional Index is a valuable prognostic marker in Mexican patients operated on and not on gastrointestinal stromal tumors. A retrospective cohort study

Prognostic Nutritional Index is a valuable prognostic marker in Mexican patients operated on and not on gastrointestinal stromal tumors. A retrospective cohort study

The predictive value of serum NLR, SII, and OPNI for lymph node metastasis in breast cancer patients with internal mammary lymph nodes after thoracoscopic surgery

Interpretations of the Role of Plasma Albumin in Prognostic Indices: A Literature Review

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