Prognostic role of preoperative D-dimer, fibrinogen and platelet levels in patients with oral squamous cell carcinoma

Abstract

Background The relationship between cancer and coagulation has been intensively studied in recent years; however, the effects of coagulation factors on oral squamous cell carcinoma (OSCC) have rarely been reported. This study aimed to investigate the relationship between preoperative D-dimer (DD), fibrinogen (FIB), platelets (PLT) and OSCC, as well as the prognostic value of DD, FIB and PLT in OSCC. Methods We retrospectively investigated a total of 202 patients with OSCC treated at Guanghua Hospital of Stomatology, Sun Yat-sen University. Baseline demographic and clinicopathological information as well as both preoperative and postoperative DD, FIB and PLT results were collected from each patient, and patients with primary OSCC were followed up for disease progression, death or the end of the study. The correlations between preoperative DD, FIB, PLT and other clinical features, as well as the therapeutic effect and PFS were analysed statistically, and postoperative DD and surgical parameters were also analysed. Results Preoperative DD was significantly correlated with T stage, N stage, clinical stage and relapse of OSCC (P = 0.000, 0.001, 0.000 and 0.000, respectively). Univariate Cox regression analyses showed that high preoperative DD predicted poor prognosis in patients with OSCC (HR = 2.1, P = 0.033), while FIB and PLT showed no prognostic values. Postoperative DD was significantly correlated with preoperative DD and surgical type but not the duration of surgery (P = 0.005, 0.001 and 0.244, respectively). Conclusion In this study, we suggested that high preoperative DD level may serve as an indicator for synchronous neck dissection in patients with T1, 2 OSCC, and the elevated DD level might be the marker of disease progression in patient follow up.

A Clinical Prognostic Model Based on Preoperative Hematological and Clinical Parameters Predicts the Progression of Primary WHO Grade II Meningioma

“…However, most of these individualized medical treatments based on gene detection are invasive and expensive and cannot fully define the spatial heterogeneity of tumors. Numerous studies have demonstrated that hematological parameters have great potential in tumor prognostic stratification (7,9,(19)(20)(21); unlike genetic markers, hematological parameters obtained from preoperative peripheral blood tests have the advantages of non-invasiveness, low cost, and easy access. Previous studies have demonstrated that high preoperative levels of NLR and FIB and low levels of LMR are associated with adverse clinical outcomes of AM (7,11,22).…”

“…The coagulation system is an integral component of the unique vascular microenvironment for tumor proliferation and progress ( 28 , 29 ). FIB and DD, as important factors in the coagulation cascade and fibrinolysis processes, respectively, have been shown to be involved in the invasive process of a variety of malignancies ( 8 , 19 , 30 ). The “net” constructed by FIB in the extracellular matrix promotes cell adhesion and tumor invasion ( 30 ); in addition, FIB ultimately promotes angiogenesis and tumor growth by binding to growth factors such as vascular endothelial growth factor and fibroblast growth factor-2 ( 31 , 32 ).…”

“…The “net” constructed by FIB in the extracellular matrix promotes cell adhesion and tumor invasion ( 30 ); in addition, FIB ultimately promotes angiogenesis and tumor growth by binding to growth factors such as vascular endothelial growth factor and fibroblast growth factor-2 ( 31 , 32 ). Previous studies have found that a high level of DD induces the progression of oral squamous cell carcinoma, cervical cancer, and glioma ( 13 , 19 , 33 ). In our study, the AUCs of FIB and DD for the diagnosis of meningioma progression were 0.615 and 0.593 in the training cohort, respectively, and their weighting coefficients in the HRM were 0.199 and 0.712, respectively; this also confirmed that high levels of FIB and DD were risk factors for the progression of AM.…”

Therapeutic Perspectives for the Perioperative Period in Oral Squamous Cell Carcinoma (OSCC)

“…Detection of CTC represents an independent risk factor of recurrence and clotting may be a protective mechanism for these cells, ensuring their perioperative dissemination. Recent studies showing the prognostic value of biomarkers of hemostasis in surgical OSCC [ 32 , 33 ] open the interesting possibility of better and more personalized anticoagulation strategies during the perioperative period.…”

Early Prediction of Objective Response of Fibrinogen in a Real-World Cohort of Hepatocellular Carcinoma Cases Treated by Programmed Cell Death Receptor-1 and Lenvatinib

“…[19][20][21][22] During tumor progression, due to metastasis, infiltration and destruction of malignant cells, abundant pro-coagulant substances are released into the blood, leading to hypercoagulable state. [23][24][25] Ji et al reported that high plasma fibrinogen levels were significantly related to poor prognosis of cases with gastrointestinal malignant tumor. 22 Nevertheless, the correlation between FIB (fibrinogen) and prognosis in unresectable HCC patients treated with lenvatinib and PD-1 (programmed cell death receptor-1) remains to be investigated.…”