Prognostic role of pregnancy occurring before or after treatment of early breast cancer patients aged &lt;35 years

Largillier, R.; Savignoni, Alexia; Gligorov, J.; Chollet, Philippe; Guilhaume, M.N.; Spielmann, M.; Luporsi, É.; Asselain, Bernard; Coudert, Bruno; Namer, M.

doi:10.1002/cncr.24608

Cited by 53 publications

(41 citation statements)

References 64 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a population-based analysis by Ives et al [13], subsequentpregnancywasevenassociatedwithsignificantly improved overall survival. Furthermore, a recent study by Largillier et al [14] analyzed 118 cases of pregnancy after breast cancer treatment and demonstrated that a pregnancy resultedina77%decreaseofdeath(p <0.001).Comparable resultswereobservedinotherstudies [15][16][17].…”

Section: Influence Of the Pregnancy On The Course Of Cancersupporting

confidence: 54%

Pregnancy after Successful Cancer Treatment: What Needs to Be Considered?

et al. 2012

View full text Add to dashboard Cite

Over the last decade, advances in oncology led to improved treatment results and increasing numbers of long-term cancer survivors. Fulfilling the desire to have children is important for many patients after cancer treatment. Consequently, oncologists, gynecologists and obstetricians are seeing more patients who wish to conceive after treatment. The necessary prerequisites that should be considered when supporting a planned pregnancy after cancer treatment are discussed in this article. The possible consequences of chemotherapy and radiotherapy on the course of pregnancy and the health of the offspring, as well as the interactions between cancer and pregnancy, are reviewed with the focus on childhood cancer, malignant lymphomas, and breast cancer. Despite chemo- or radiotherapy, neither the teratogenic risk nor the risk of adventitious cancers appears to be increased for the offspring of cancer survivors. However, there is a slightly higher risk of miscarriage after chemotherapy. In case of radiation to the uterus, there is a higher risk of premature birth, intrauterine growth retardation, and increased perinatal mortality. The effect is more pronounced after prepubertal radiation than for postpubertal radiation. The former cancer patient’s desire to conceive can nevertheless be supported, given that pregnancy and birth are closely monitored.

show abstract

Section: Influence Of the Pregnancy On The Course Of Cancersupporting

confidence: 54%

Pregnancy after Successful Cancer Treatment: What Needs to Be Considered?

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Becoming pregnant after a diagnosis of breast cancer does not appear to result in worse outcomes in case-control studies or cohort studies (4,5,7,8). In fact, in several series, pregnancy after a diagnosis of breast cancer appeared to result in a reduced risk of relapse (7)(8)(9), particularly for women who waited for 2 years after diagnosis to conceive (9).…”

Section: Will Pregnancy After a Breast Cancer Diagnosis Increase The mentioning

confidence: 98%

“…In fact, in several series, pregnancy after a diagnosis of breast cancer appeared to result in a reduced risk of relapse (7)(8)(9), particularly for women who waited for 2 years after diagnosis to conceive (9). A theoretical risk for women undergoing ovarian harvest before chemotherapy and later reimplantation (see below) is reintroduction of viable tumor cells micrometastatic to the ovary at diagnosis.…”

Section: Will Pregnancy After a Breast Cancer Diagnosis Increase The mentioning

confidence: 99%

Breast cancer and fertility preservation

Fabian¹,

Klemp²

2011

Principles and Practice of Fertility Preservation

View full text Add to dashboard Cite

Objective-To review the benefits of adjuvant systemic therapy given to women with breast cancer of reproductive age, its effects on fertility, and options for fertility preservation.Design-Publications relevant to fertility preservation and breast cancer were identified through a PubMed database search. Conclusion(s)-Mostwomen who develop invasive breast cancer under age 40 will be advised to undergo adjuvant chemotherapy with or without extended antihormonal therapy to reduce the risk of recurrence and death from breast cancer. Adjuvant chemotherapy particularly with alkylating agents such as cyclophosphamide is gonadotoxic and markedly accelerates the rate of age-related ovarian follicle loss. Although loss of fertility is an important issue for young cancer survivors, there is often little discussion about fertility preservation before initiation of adjuvant therapy. Greater familiarity with prognosis and effects of different types of adjuvant therapy on the part of infertility specialists and fertility preservation options such cryopreservation of embryos, oocytes, and ovarian tissue on the part of oncologists would facilitate these discussions. Establishment of rapid fertility consultation links within cancer survivorship programs can help ensure that every young woman who is likely to undergo gonadotoxic cancer treatment is counseled about the effects of therapy and options available to her to increase the likelihood of childbearing after cancer treatment. KeywordsBreast cancer; fertility preservation; embryo cryopreservation; oocyte cryopreservation; ovarian tissue cryopreservation; ovarian transplantation; GnRH agonist; chemotherapy; cancer survivorshipIn the United States, 5%-7% of cases of invasive breast cancer (~11,000/year) occur in women who are under age 40 at diagnosis (www.seer.cancer.gov.2008), most between the ages of 30 and 40 (1). As almost one quarter of first live births in the United States occur between the ages of 30 and 40, many of these women will not have had the opportunity to bear a child (2). Less than 10% of women who develop invasive breast cancer under age 40 have children postdiagnosis (3-5), despite survey results suggesting about half desire to do so (6) and observational studies that do not indicate an increased risk of relapse or death for women who become pregnant after a breast cancer diagnosis (7-9). Receipt of cytotoxic chemotherapy is a major factor in the low rate of live births after a diagnosis of breast

show abstract

“…Dans l'étude du groupe GETNA, réalisée chez 908 patientes âgées de moins de 35 ans traitées pour un cancer du sein entre 1990-1999, a été évalué le risque entraîné par la survenue d'une grossesse après traitement [105]. Treize pour cent des patientes ont mené à terme une grossesse spontanée après traitement du cancer du sein et aucun effet délétère sur la survie globale n'a été mis en évidence.…”

Section: Veille Bibliographiqueunclassified

“…Treize pour cent des patientes ont mené à terme une grossesse spontanée après traitement du cancer du sein et aucun effet délétère sur la survie globale n'a été mis en évidence. Avec un risque relatif de 0,23 et une valeur de p infé-p infé-p rieure à 0,001, la survie à cinq ans était de 97 % pour les patientes ayant une grossesse contre 80 % en l'absence de grossesse [105].…”

Section: Veille Bibliographiqueunclassified