Prognostic role of neutrophil to lymphocyte ratio&amp;nbsp;in lung cancers: a meta-analysis including 7,054 patients

Zhao, Qingtao; Yang, Yong; Xu, Shun; Zhang, Xiao-Peng; Wang, Huien; Zhang, Hua; Wang, Zhikang; Zheng, Yuxin; Duan, Guochen

doi:10.2147/ott.s90875

Cited by 46 publications

(44 citation statements)

References 45 publications

(38 reference statements)

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“…Optimal thresholds of NLR, PLR and LMR in our study were similar to the studies in other malignants424344. The AUC of GPS, CRP, NLR, PLR, LMR, and NPS were compared, and GPS and NLR had a markedly larger AUC than CRP, PLR, LMR, and NPS (Table 5 and Fig.…”

Section: Discussionsupporting

confidence: 86%

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Prognostic value of inflammation-based scores in patients with osteosarcoma

Liu

Huang

Sun

et al. 2016

Sci Rep

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Systemic inflammation responses have been associated with cancer development and progression. C-reactive protein (CRP), Glasgow prognostic score (GPS), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lymphocyte-monocyte ratio (LMR), and neutrophil-platelet score (NPS) have been shown to be independent risk factors in various types of malignant tumors. This retrospective analysis of 162 osteosarcoma cases was performed to estimate their predictive value of survival in osteosarcoma. All statistical analyses were performed by SPSS statistical software. Receiver operating characteristic (ROC) analysis was generated to set optimal thresholds; area under the curve (AUC) was used to show the discriminatory abilities of inflammation-based scores; Kaplan-Meier analysis was performed to plot the survival curve; cox regression models were employed to determine the independent prognostic factors. The optimal cut-off points of NLR, PLR, and LMR were 2.57, 123.5 and 4.73, respectively. GPS and NLR had a markedly larger AUC than CRP, PLR and LMR. High levels of CRP, GPS, NLR, PLR, and low level of LMR were significantly associated with adverse prognosis (P < 0.05). Multivariate Cox regression analyses revealed that GPS, NLR, and occurrence of metastasis were top risk factors associated with death of osteosarcoma patients.

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Section: Discussionsupporting

confidence: 86%

“…Platelets were also reported to act as chemoattractants, increasing the migration of ovarian cancer cells41. NLR, PLR, LMR, and NPS have been shown to be independent risk factors in various malignant tumors18424344. These factors when combined may have stronger prognosis value than any single one.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of inflammation-based scores in patients with osteosarcoma

Liu

Huang

Sun

et al. 2016

Sci Rep

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“…In recent years, some meta-analyses have supported the prognostic value of preoperative NLR in lung cancer 4,21,22. However, these studies enrolled patients with different stages of disease, especially patients with small-cell lung cancer, the biological behavior and prognosis of which differ from those of NSCLC.…”

Section: Discussionmentioning

confidence: 99%

The postoperative neutrophil-to-lymphocyte ratio and changes in this ratio predict survival after the complete resection of stage I non-small cell lung cancer

Jin¹,

Han

Shi

et al. 2016

OTT

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PurposeAlthough numerous studies have demonstrated associations between the preoperative neutrophil-to-lymphocyte ratio (NLR) and long-term outcomes in patients with non-small cell lung cancer (NSCLC), the prognostic significance of postoperative NLR and change in NLR (ΔNLR) is unknown for patients who underwent complete resection of stage I NSCLC. The aim of this retrospective study was to evaluate the prognostic significance of postoperative NLR and ΔNLR in 123 patients with stage I NSCLC.Patients and methodsThis retrospective study included preoperative and postoperative data of 123 patients who underwent surgical resection for stage I NSCLC. The relationship between disease-free survival (DFS), overall survival (OS), and clinicopathological factors, including NLR, lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio, and their changes, was analyzed using both univariate Kaplan–Meier and multivariate Cox regression methods.ResultsThe 5-year DFS and OS rates in our cohort were 60.16% and 67.48%, respectively. Univariate analysis revealed that age (P=0.045), smoking status (P=0.033), preoperative NLR (P=0.032), postoperative NLR (P<0.001), ΔNLR (P=0.004), and change in LMR (ΔLMR) (P=0.025) were significant predictors of DFS and that age (P=0.039), smoking status (P=0.042), postoperative NLR (P<0.001), ΔNLR (P=0.004), and ΔLMR (P=0.011) were independent predictors of OS. Multivariate analysis confirmed that postoperative NLR (hazard ratio [HR] =2.435, P=0.001) and ΔNLR (HR =2.103, P=0.012) were independent predictors of DFS and that postoperative NLR (HR =2.747, P=0.001) and ΔNLR (HR =2.052, P=0.018) were significant prognostic factors of OS.ConclusionOur study reported for the first time that postoperative NLR and ΔNLR – but not preoperative NLR – were independent prognostic factors of DFS and OS in patients with stage I NSCLC who underwent complete resection. This easily available biomarker might be helpful in individual risk assessment.

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“…10 Ayrıca, nötrofiller ile lenfositler arasındaki dengesizliğin tümör hipoksisi ya da nekrozuna sebep olabileceği ve antiapoptotik etkiler ile ilişkili olduğu üzerinde durulmaktadır. 23 Çalışmamızda ülseratif meme tümörlü köpeklerde ölçülen WBC değerleri istatistiksel açıdan önemli olup (p<0,01), nonülseratif meme tümörlü köpeklere göre daha yüksek miktarlarda saptanması araştırmacıların bildirisiyle uyumludur. 23 Bunun yanı sıra, araştırmacıların bildirileri doğrultusunda PLT miktarındaki artışın lökositleri de etkileyerek artırdığı düşünülmektedir.…”

Section: Discussionunclassified

“…23 Çalışmamızda ülseratif meme tümörlü köpeklerde ölçülen WBC değerleri istatistiksel açıdan önemli olup (p<0,01), nonülseratif meme tümörlü köpeklere göre daha yüksek miktarlarda saptanması araştırmacıların bildirisiyle uyumludur. 23 Bunun yanı sıra, araştırmacıların bildirileri doğrultusunda PLT miktarındaki artışın lökositleri de etkileyerek artırdığı düşünülmektedir. 10,22 Çalışma grubundaki köpeklerde kitle büyüklüğü ile WBC miktarları arasındaki pozitif korelasyonun, araştırmacıların bildirisinde açıklandığı gibi tümör hipoksisi nedeni ile kaynaklandığı düşünülmektedir.…”

Section: Discussionunclassified

Evaluation of Relationship Between Clinical and Some Hematological Parameters in Bitches with Malignant Mammary Tumor

Uçmak¹,

Güvenç²

2019

Turkiye Klinikleri J Vet Sci

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Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışmada; sağlıklı ve meme tümörlü köpeklerde beyaz kan hücreleri [white blood cell (WBC)], platelet (PLT) ve kandan izole edilen total ribonükleik asit (RNA) miktarlarının karşılaştırılması ve ayrıca; tümör tipi, kitle büyüklüğü, kitle sayısı, yaş, ülserasyon ve metastaz varlığı gibi klinik bulgular ile belirtilen hematolojik parametreler arasındaki ilişkinin ortaya konulması amaçlandı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Araştırmanın materyalini, ortalama 5,94±1,21 yaşında 9 adet sağlıklı dişi köpek ve ortalama 11,19±0,41 yaşında 45 adet meme tümörlü dişi köpek oluşturdu. Bunun yanında, kısırlaştırma amacıyla kliniğimize getirilen köpekler ise kontrol grubu olarak kullanıldı. Operasyon öncesi dönemde hemogram ve total RNA izolasyonu amacıyla kan örnekleri alındı. Total RNA izolasyonu kit prosedürüne uygun olarak gerçekleştirildi. B Bu ul lg gu ul la ar r: : Çalışma ve kontrol grubundaki köpekler yaş, PLT, WBC, total RNA miktarı açısından değerlendirildi. Bunun sonucunda; yaş (p<0,001), PLT (p<0,05), total RNA (p<0,05) miktarları meme tümörlü köpeklerde daha yüksek miktarda ölçüldü. Ayrıca, meme tümörlü köpeklerde WBC değerleri ile kitle büyüklüğü (p<0,05) ve total RNA miktarları (p<0,001) arasında pozitif korelasyon saptandı. Bunun yanı sıra, ülsere tümörlü köpeklerde WBC miktarının daha yüksek olduğu belirlendi (p<0,01). S So on nu uç ç: : Bu çalışmada; PLT miktarının karsinojenik olgularda arttığı tespit edildi. Ayrıca, meme tümörlü köpeklerde prognostik tümör belirteçlerinin (biyomarkerların) saptanabilmesi için kandan izole edilen total RNA miktarının, WBC miktarı ile ilişkili olduğu sonucuna varıldı. Elde edilen bulguların tümör patofizyolojisi ile ilgili moleküler düzeydeki çalışmalara katkı sağlayacağı düşünülmektedir.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Kan trombositleri; lökositler; meme neoplazmaları; total RNA A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The amount of white blood cell (WBC), platelet (PLT) and total ribonucleic acid (RNA) isolated from blood in healthy bitches and bitches with mammary tumors (MT) were compared in this study. Also, determination of the relationship between hematological parameters and clinical findings such as tumor type, mass size, number of mass, age, ulceration and metastasis was aimed. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : The material of the research was composed of the data belonging to the 9 healthy bitches approximately 5.95±1.21 years old and 45 bitches with MT approxiamtely 11.19±0.41 years old. Control group included the bithces which were presented to our clinic for ovariohysterectomy. Blood samples were collected in preoperative term for total RNA isolation and hemogram. Total RNA isolation was performed according to kit procedure. R Re es su ul lt ts s: : Bitches in study and control group were evaluated in terms of age, PLT, WBC and total RNA values. Consequently, age (p<0.001), PLT (p<0.05) and total RNA (p<0.05) values were detected higher in bitch...

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Prognostic role of neutrophil to lymphocyte ratio in lung cancers: a meta-analysis including 7,054 patients

Cited by 46 publications

References 45 publications

Prognostic value of inflammation-based scores in patients with osteosarcoma

Prognostic value of inflammation-based scores in patients with osteosarcoma

The postoperative neutrophil-to-lymphocyte ratio and changes in this ratio predict survival after the complete resection of stage I non-small cell lung cancer

Evaluation of Relationship Between Clinical and Some Hematological Parameters in Bitches with Malignant Mammary Tumor

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