Prognostic Role of miR-205 in Early-Stage (T1N0) Non-Small Cell Lung Cancer

Boldrini, Laura; Giordano, Mirella; Servadio, Adele; Alì, Greta; Cocco, Alice; Lucchi, Marco; Bertoglio, Pietro; Melfi, Franca; Mussi, Alfredo; Fontanini, Gabriella

doi:10.4236/alc.2014.32007

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…have shown that miR‐92a expression was an unfavorable prognostic marker for nasopharyngeal carcinoma, while the co‐expression of miR‐18a and miR‐92 as part of the miR‐17/92 cluster, also known as oncomiR‐1, was associated to worst prognostic outcomes in esophageal squamous cell carcinoma . Among other identified miRNAs, previous studies also reported that miR‐103 is an unfavorable prognostic factor for breast and colorectal cancer, while miR‐103 appears as a poor prognostic marker in endometrial and early stage non‐small‐cell lung cancer . In addition, expression of miR‐548b was noted to be an important indicator of good prognostic outcomes for Axl‐driven non‐small‐cell lung cancer …”

Section: Discussionmentioning

confidence: 99%

Four PTEN‐targeting co‐expressed miRNAs and ACTN4‐ targeting miR‐548b are independent prognostic biomarkers in human squamous cell carcinoma of the oral tongue

Berania

Cardin

Clément

et al. 2017

Intl Journal of Cancer

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The purpose of this study was to determine the prognostic value and oncogenic pathways associated to miRNA expression in squamous cell carcinoma of the oral tongue and to link these miRNA candidates with potential gene targets. We performed a miRNA screening within our institutional cohort (n = 58 patients) and reported five prognostic targets including a cluster of four co-expressed miRNAs (miR-18a, miR-92a, miR-103, and miR-205). Multivariate analysis showed that expression of miR-548b (p = 0.007) and miR-18a (p = 0.004, representative of co-expressed miRNAs) are independent prognostic markers for squamous cell carcinoma of the oral tongue. These findings were validated in The Cancer Genome Atlas (TCGA) cohort (n = 131) for both miRNAs (miR-548b: p = 0.027; miR-18a: p = 0.001). Bioinformatics analysis identified PTEN and ACTN4 as direct targets of the four co-expressed miRNAs and miR-548b, respectively. Correlations between the five identified miRNAs and their respective targeted genes were validated in the two merged cohorts and were concordantly significant (miR-18a/PTEN: p < 0.0001; miR-92a/PTEN: p = 0.0008; miR-103/PTEN: p = 0.008; miR-203/PTEN: p = 0.019; miR-548b/ACTN4: p = 0.009).

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