Prognostic role of miR-17-92 family in human cancers: evaluation of multiple prognostic outcomes

Abstract

Recent evidence indicates that miR-17–92 family might be an essential prognostic biomarker for human cancers. However, results are still inconsistent. We therefore performed a meta-analysis to evaluate the predictive role of miR-17–92 family in human cancer prognosis. We searched literatures published before March 31th, 2017 inPubMed, Cochrane and Embase databases. Twenty six studies were included in our analyses. The overall hazard ratios (HRs) showed that high expression level of miR-17-92 family was a predictor of poor overall survival (OS): adjusted HRs = 1.71, 95% confidence intervals (CIs): 1.39–2.11, p < 0.00001, and poor disease-free survival (DFS): adjusted HRs = 2.29, 95% CIs: 1.41–3.72, p = 0.0008. However, no association between miR-17-92 family expression and cancer progress-free survival (PFS) was found (p > 0.05). Subgroup analyses showed that high expression of miR-17-92 family was associated with poor OS (adjusted HRs = 1.89, 95% CIs: 1.43–2.49, p < 0.00001) and DFS (adjusted HRs = 2.83, 95% CIs: 1.59–5.04, p = 0.0003) among the Asian, and no association was found for the Caucasian (p > 0.05). Besides, the HRs of miR-17-92 family high expression in tissue and serum samples was 1.68 (1.35–2.09) and 2.20 (1.08–4.46) for OS, and 1.73 (0.80–3.74) and 3.37 (2.25–5.02) for DFS. It also found that high expression of miR-17-92 family predicted a poor OS in breast cancer, esophageal squamous cell carcinoma, lymphoma and other cancers. Findings suggest that miR-17-92 family can be an effective predictor for prognosis prediction in cancer patients.

Long Noncoding RNA FER1L4 Suppresses Tumorigenesis by Regulating the Expression of PTEN Targeting miR-18a-5p in Osteosarcoma

“…To investigate the anti-cancer mechanism of lncRNA in OS, we predicted the candidate miRNAs of FER1L4, using the starBase v2.0 software. Among the target miRNAs, miR-18a-5p was selected as the study object, based on its biological function in various cancers [19,20]. miR-18a-5p, Cellular Physiology and Biochemistry a member of the miR-17-92 cluster, has been reported to be upregulated, and functions as an oncogene in OS progression [25][26][27].…”

Micro RNA Transcriptome Profile in Canine Oral Melanoma

“…The miR-20b seed sequence is similar to that of human miR-17-5p, and miR-106a belongs to the miR-17-92 family. Over-expression of hsa-miR-17 and miR-106a is a good predictor of poor overall survival in several human cancers [33], indicating these miRNAs may be a prognostic marker and also a good therapeutic option in both species.…”

Regulat-INGs in tumors and diseases: Focus on ncRNAs

“…For example, the miR-17-92 has been shown to be upregulated in several solid and hematopoietic cancers (45)(46)(47)(48). Indeed, by targeting TSG, such as PTEN (49), miR-17-92 cluster containing miR-17-5p, miR-17-3p, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92a-1, can promote oncogenesis, is associated with poor survival and thus is considered an oncomiR (46,47,50,51). In contrast, miR-217 is considered as tumor suppressor because its overexpression decreases cancer invasion and migration by targeting Enhancer of Zeste Homolog 2 (EZH2) in gastric cancer (52), known to enhance cell cycle or PTPN14, which modulates epithelial-to-mesenchymal transition (53).…”