Prognostic role of lymphovascular invasion and lymph node status among breast cancer subtypes

Liao, Guo‐Shiou; Hsu, Huan-Ming; Chu, Chin-Chen; Hong, Zhi-Jie; Fu, Chih-Yuan; Chou, Yu-Ching; Golshan, Mehra; Dai, Ming‐Shen; Chen, Teng-Wei; De-Chian, Chan; Tsai, Wan‐Chen; Pan, Chao-Wen; Hsu, Kuo-Feng; Kao, En-Nung; Hsu, Yi-Chih; Chang, Tsun-Hou; Yu, Jyh‐Cherng

doi:10.4103/jmedsci.jmedsci_105_17

Cited by 8 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Basal cytokeratins are strongly associated with high histological grade, negative hormone status and worse patient outcome [39,49]. Among subgroups, overexpression of IDH2 protein appears to play a particularly significant role in luminal B subtype which is in concordance with a recent study [50].…”

Section: Discussionsupporting

confidence: 80%

The prognostic significance of wild-type isocitrate dehydrogenase 2 (IDH2) in breast cancer

Aljohani

Toss

Kurozumi

et al. 2019

Breast Cancer Res Treat

View full text Add to dashboard Cite

Background Lymphovascular invasion (LVI) is a prerequisite step in breast cancer (BC) metastasis. We have previously identified wild-type isocitrate dehydrogenase 2 (IDH2) as a key putative driver of LVI. Thus, we explored the prognostic significance of IDH2 at transcriptome and protein expression levels in pre-invasive and invasive disease. Methods Utlising tissue microarrays from a large well annotated BC cohort including ductal carcinoma in situ and invasive breast cancer (IBC), IDH2 was assessed at the transcriptomic and proteomic level. The associations between clinicopathological factors including LVI status, prognosis and the expression of IDH2 were evaluated. Results In pure DCIS and IBC, high IDH2 protein expression was associated with features of aggressiveness including high nuclear grade, larger size, comedo necrosis and hormonal receptor negativity and LVI, higher grade, larger tumour size, high NPI, HER2 positivity, and hormonal receptor negativity, respectively. High expression of IDH2 either in mRNA or in protein levels was associated with poor patient’s outcome in both DCIS and IBC. Multivariate analysis revealed that IDH2 protein expression was an independent risk factor for shorter BC specific-survival. Conclusion Further functional studies to decipher the role of IDH2 and its mechanism of action as a driver of BC progression and LVI are warranted.

show abstract

Section: Discussionsupporting

confidence: 80%

The prognostic significance of wild-type isocitrate dehydrogenase 2 (IDH2) in breast cancer

Aljohani

Toss

Kurozumi

et al. 2019

Breast Cancer Res Treat

View full text Add to dashboard Cite

show abstract

Breast cancer larger than 2.5 cm with tumor-free radioisotope-hot sentinel nodes has higher risk of non-hot axillary lymph node metastasis

Liu

Kuo

et al. 2022

Biomedical Journal

View full text Add to dashboard Cite

Relationship between lymphovascular invasion and molecular subtypes in invasive breast cancer

et al. 2020

View full text Add to dashboard Cite

Purpose The aim of this study is to evaluate the relation between LVI and molecular subtypes in invasive breast cancers and to find out whether LVI which is a histopathologic indicator has a role in subtype classification or not. Methods One hundred and seventy‐six patients who had mastectomy for breast cancer between 2013 and 2018 in the Department of Surgical Oncology, Faculty of Medicine, Ankara University were retrospectively analysed. One hundred and thirty‐two patients who had LVI, ER, PR, Her 2 and Ki‐67 index status information provided in their pathology results were included in the study. The relationship between molecular subtypes and LVI was investigated. Results One hundred and thirty‐two patients were analysed retrospectively. Eighty‐two patients had LVI and 50 patients had not. We found a relationship between Luminal B with Her2(−) and LVI, basal like and LVI (P = .00). No significant statistical difference was found between LVI and other molecular subtypes. We confirmed these results with multiple variable analysis (%77.3 correlation). Conclusions As a result, we found that LVI can affect molecular subtypes. This showed that a histopathological factor may affect tumour biology. In other words, breast cancer is a heterogeneous disease with many different predictors and prognostic variables.

show abstract

Prognostic role of lymphovascular invasion and lymph node status among breast cancer subtypes

Cited by 8 publications

References 0 publications

The prognostic significance of wild-type isocitrate dehydrogenase 2 (IDH2) in breast cancer

The prognostic significance of wild-type isocitrate dehydrogenase 2 (IDH2) in breast cancer

Breast cancer larger than 2.5 cm with tumor-free radioisotope-hot sentinel nodes has higher risk of non-hot axillary lymph node metastasis

Relationship between lymphovascular invasion and molecular subtypes in invasive breast cancer

Contact Info

Product

Resources

About