Prognostic Role of Lymphocyte/Monocyte Ratio in Chronic Lymphocytic Leukemia

Yokuş, Osman; Saglam, Esma Nur; Goze, Hasan; Sametoglu, Fettah; Serin, İstemi

doi:10.14740/jh730

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…The putative association between initial monocyte proportion in autologous cultures and CLL cell survival or patient outcome remains to be studied clinically, despite some evidence that monocyte count in CLL patients can be prognostic. 69 , 70 Heterogeneity across patients is well known 71 and the formation of NLCs might be extremely patient-specific in both time scales, numbers, and phenotypes of NLCs generated. We are aware that different dynamics could be at play in different patients, and we hoped that clinically measurable parameters, such as the initial monocyte concentration in the blood, could help us produce a generally useful model that can give specific predictions.…”

Section: Discussionmentioning

confidence: 99%

An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia

et al. 2023

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Section: Discussionmentioning

confidence: 99%

An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia

et al. 2023

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“…We believe that some other patient-specific features need to be considered to obtain better predictions. The putative association between initial monocyte proportion in autologous cultures and CLL cell survival or patient outcome remains to be studied clinically, despite some evidence that monocyte count in CLL patients can be prognostic (68, 69). Heterogeneity across patients is well known (70) and the formation of NLCs might be extremely patient-specific in both time scales, numbers, and phenotypes of NLCs generated.…”

Section: Discussionmentioning

confidence: 99%

An Agent-Based Model of Monocyte Differentiation into Tumour-Associated Macrophages in Chronic Lymphocytic Leukemia

Verstraete

Marku

Domagala

et al. 2021

Preprint

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Monocyte-derived macrophages are immune cells which help maintain tissue homeostasis and defend the organism against pathogens. In solid tumours, recent studies have uncovered complex macrophage populations, among which tumour-associated macrophages, supporting tumorigenesis through multiple cancer hallmarks such as immunosuppression, angiogenesis or matrix remodelling. In the case of chronic lymphocytic leukemia, these macrophages are known as nurse-like cells and have been shown to protect leukemic cells from spontaneous apoptosis and contribute to their chemoresistance. We propose an agent-based model of monocytes differentiation into nurse-like cells upon contact with leukemic B cells in-vitro. We studied monocyte differentiation and cancer cells survival dynamics depending on diverse hypotheses on monocytes and cancer cells relative proportions, sensitivity to their surrounding environment and cell-cell interactions. Peripheral blood mononuclear cells from patients were cultured and monitored during 13 days to calibrate the model parameters, such as phagocytosis efficiency, death rates or protective effect from the nurse-like cells. Our model is able to reproduce experimental results and predict cancer cells survival dynamics in a patient-specific manner. Our results shed light on important factors at play in cancer cells survival, highlighting a potentially important role of phagocytosis.

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Hematologic parameters in female alpacas during age progression: a retrospective study

Wagener,

Kornblum,

Kiene

et al. 2024

Sci Rep

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Alpacas, like all camelids, have elliptical red blood cells (RBCs) in contrast to other mammals. This particular shape is important for increased osmotic resistance and stability. Age-related changes in the RBC count are known in other species, with alterations in both red and white blood cells being described. In alpacas, there are few data on age-related changes, and only a comparison of crias with adult animals. We characterized age-related hematologic changes in a study of 21 female alpacas from a research herd. A total of 87 records of clinically healthy alpacas of different ages were statistically analyzed retrospectively from the hematologic records over a nine-year period. Significant positive correlations of age with hemoglobin (Hb), HCT, MCV, MCH, neutrophils, platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) were found as well as significant negative correlations of age with lymphocytes in addition to lymphocyte-to-monocyte ratio (LMR). A paired comparison of eight older animals in the herd at three different ages also showed significant differences in the parameters Hb, HCT, MCV, MCH, MCHC, lymphocytes, eosinophils and neutrophils. Similar changes in hematologic parameters have been reported in other species and should be taken into account when interpreting hematologic results in alpacas.

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Prognostic Role of Lymphocyte/Monocyte Ratio in Chronic Lymphocytic Leukemia

Cited by 3 publications

References 21 publications

An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia

An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia

An Agent-Based Model of Monocyte Differentiation into Tumour-Associated Macrophages in Chronic Lymphocytic Leukemia

Hematologic parameters in female alpacas during age progression: a retrospective study

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