Prognostic Role of Hepatoma-derived Growth Factor in Solid Tumors of Eastern Asia: a Systematic Review and Meta-Analysis

Bao, Cihang; Liu, Kun; Wang, Xin-Tong; Ma, Wei; Wang, Jianbo; Jia, Yibin; Wang, Nana; Tan, Bingxu; Song, Qingxu; Cheng, Yufeng

doi:10.7314/apjcp.2015.16.5.1803

Cited by 9 publications

(7 citation statements)

References 50 publications

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“…However, none of the aforementioned confounding effects could completely explain the heterogeneity. Instead, we used a random-effects model to calculate the consolidated results to minimize the influence of heterogeneity to certain degree [26]. Moreover, as our meta-analysis was limited to published literatures, valuable information from studies with negative outcomes and small sample sizes could have been overlooked.…”

Section: Discussionmentioning

confidence: 99%

Association between tumor-stroma ratio and prognosis in solid tumor patients: a systematic review and meta-analysis

et al. 2016

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Tumor-related stroma plays an active role in tumor invasion and metastasis. The tumor-stroma ratio (TSR) in the pathologic specimen has drawn increasing attention from the field of predicting tumor prognosis. However, the prognostic value of TSR in solid tumors necessitates further elucidation. We conducted a meta-analysis on 14 studies with 4238 patients through a comprehensive electronic search on databases updated on May 2016 to explore the relationship between TSR and prognosis of solid tumors. The overall hazard ratio showed that rich stroma in tumor tissue was associated with poor overall survival (OS) (14 studies, 4238 patients) and diseasefree survival (DFS) (9 studies, 2235 patients) of patients with solid tumors. The effect of low TSR on poor OS was observed among various cancer types, but not in the early stage of cervical caner. A significant relationship between low TSR and poor OS was also observed in the subgroup analyses based on study region, blinding status, and Newcastle-Ottawa Scale (NOS) score. Subgroup analyses indicated that cancer type, clinical stage, study region, blinding status, and NOS score did not affect the prognostic value of TSR for DFS. Moreover, low TSR was significantly correlated with the serious clinical stage, advanced depth of invasion, and positive lymph node metastasis. These findings indicate that a high proportion of stroma in cancer tissue is associated with poor clinical outcomes in cancer patients, and TSR may serve as an independent prognostic factor for solid tumors.

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Section: Discussionmentioning

confidence: 99%

Association between tumor-stroma ratio and prognosis in solid tumor patients: a systematic review and meta-analysis

et al. 2016

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“…[56,57] HDGF, hepatoma-derived growth factor; VEGF, vascular endothelial growth factor; GIST, gastrointestinal stromal tumor. Overall reviews [3][4][5] and references therein should be beneficial.…”

Section: Malignant Digestive System Diseases Main Findings Reference(s)mentioning

confidence: 99%

“…In addition, studies with human HCC samples showed a higher expression of the HDGF protein in the cancerous tissues in comparison with the adjacent non-cancerous tissues [3]. Furthermore, the increased expression of HDGF was associated with invasive and aggressive phenotypes, and with poor clinical outcomes of several malignant diseases [4,5].…”

Section: Introductionmentioning

confidence: 99%

Hepatoma-Derived Growth Factor: An Overview and Its Role as a Potential Therapeutic Target Molecule for Digestive Malignancies

Enomoto

Nakamura

Nishikawa

et al. 2020

IJMS

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Hepatoma-derived growth factor (HDGF) was identified in research seeking to find a novel growth factor for hepatoma cells. Subsequently, four HDGF-related proteins were identified, and these proteins are considered to be members of a new gene family. HDGF has a growth-stimulating role, an angiogenesis-inducing role, and a probable anti-apoptotic role. HDGF is ubiquitously expressed in non-cancerous tissues, and participates in organ development and in the healing of damaged tissues. In addition, the high expression of HDGF was reported to be closely associated with unfavorable clinical outcomes in several malignant diseases. Thus, HDGF is considered to contribute to the development and progression of malignant disease. We herein provide a brief overview of the factor and its functions in relation to benign and malignant cells. We also describe its possible role as a target molecule for digestive malignancies.

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“…HDGF stimulates the proliferation of hepatoma cells in vitro [ 10 , 11 ], and the HDGF expression is significantly higher in human HCC tissues than in adjacent non-cancerous liver tissues [ 12 ]. A high HDGF expression is related to several unfavorable cancer characteristics, including rapid growth, significant invasiveness and metastasis, and it is also associated with poor prognoses of various malignant diseases [ 13 , 14 , 15 , 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Hepatoma-Derived Growth Factor: Its Possible Involvement in the Progression of Hepatocellular Carcinoma

Enomoto

Nakamura

Liu

et al. 2015

IJMS

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The development of hepatocellular carcinoma (HCC) is an important complication of viral infection induced by hepatitis virus C, and our major research theme is to identify a new growth factor related to the progression of HCC. HDGF (hepatoma-derived growth factor) is a novel growth factor that belongs to a new gene family. HDGF was initially purified from the conditioned medium of a hepatoma cell line. HDGF promotes cellular proliferation as a DNA binding nuclear factor and a secreted protein acting via a receptor-mediated pathway. HDGF is a unique multi-functional protein that can function as a growth factor, angiogenic factor and anti-apoptotic factor and it participates in the development and progression of various malignant diseases. The expression level of HDGF may be an independent prognostic factor for predicting the disease-free and overall survival in patients with various malignancies, including HCC. Furthermore, the overexpression of HDGF promotes the proliferation of HCC cells, while a reduction in the HDGF expression inhibits the proliferation of HCC cells. This article provides an overview of the characteristics of HDGF and describes the potential role of HDGF as a growth-promoting factor for HCC.

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Prognostic Role of Hepatoma-derived Growth Factor in Solid Tumors of Eastern Asia: a Systematic Review and Meta-Analysis

Cited by 9 publications

References 50 publications

Association between tumor-stroma ratio and prognosis in solid tumor patients: a systematic review and meta-analysis

Association between tumor-stroma ratio and prognosis in solid tumor patients: a systematic review and meta-analysis

Hepatoma-Derived Growth Factor: An Overview and Its Role as a Potential Therapeutic Target Molecule for Digestive Malignancies

Hepatoma-Derived Growth Factor: Its Possible Involvement in the Progression of Hepatocellular Carcinoma

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