Prognostic role of D-dimer for in-hospital and 1-year mortality in exacerbations of COPD

Hu, Guoping; Wu, Yankui; Zhou, Yumin; Wu, Zelong; Wei, Liping; Li, Yuqun; Peng, Gongyong; Liang, Wenjie; Ran, Pixin

doi:10.2147/copd.s112882

Cited by 32 publications

(49 citation statements)

References 32 publications

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“…Studies 13 have indicated that high DDI levels is an independent risk factors for AECOPD, and our results are consistent with them. A retrospective study 14 also showed that DDI levels can be used as biomarkers for predicting short‐ and long‐term mortality in AECOPD.…”

Section: Discussionsupporting

confidence: 93%

Establishment of risk prediction model and risk score for in‐hospital mortality in patients with AECOPD

Zhu

Cai

et al. 2020

Clinical Respiratory J

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Objective Risk stratification for patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) may help clinicians choose appropriate treatments and improve the quality of care. Methods A total of 695 patients hospitalized with AECOPD from January 2015 to December 2017 were considered. They were assigned to a death and a survival cohort. The independent prognostic factors were determined by multivariate logistic regression analysis. Meanwhile, we also compared the new scale with three other scores and tested the new scale internally and externally. Results A new risk score was created, made up of six independent variables: age, D‐dimer, albumin, cardiac troponin I, partial pressure of carbon dioxide and oxygenation index. The area under the receiver operator characteristic curve (AUROC) for the model was 0.929, and the other three CURB‐65, DECAF and BAP‐65 models were 0.718, 0.922 and 0.708. The Cohen’s kappa coefficient between the new scale and DECAF was calculated to be 0.648, suggesting that there is a substantial consistency between the two. In the internal and external validation cohorts, 490 and 500 patients were recruited with a total mortality rate of 5.15%. The AUROC for in‐hospital mortality was 0.937 in the internal cohort and 0.914 in external cohort, which was significantly better than the scores for CURB‐65 and BAP‐65, but it was not significantly different from the DECAF. Conclusions The new scale may help to stratify the risk of in‐hospital mortality of AECOPD. The DECAF performed as well as the new instrument, and it appears to be valid in Chinese patients.

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Section: Discussionsupporting

confidence: 93%

Establishment of risk prediction model and risk score for in‐hospital mortality in patients with AECOPD

Zhu

Cai

et al. 2020

Clinical Respiratory J

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“…In addition to its diagnostic value, D-dimer levels are also of great prognostic significance and are associated with outcomes in many diseases. Serum D-dimer levels are associated with outcomes in patient with stroke, acute myocardial infarction, A acute aortic dissection, carcinoma, COPD 32 – 35 .…”

Section: Discussionmentioning

confidence: 99%

Serum D-dimer is a potential predictor for thromboembolism complications in patients with renal biopsy

Tan

Chen

Liu

et al. 2017

Sci Rep

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Renal biopsy has been widely recommended in clinic to determine the histological patterns of kidney disease. To prevent bleeding complications, patients should routinely stop anticoagulants prior to renal biopsy. However, patients with kidney disease are susceptible to thromboembolisms, particularly in those with severe hypoalbuminemia. This study was designed to investigate the application of serum D-dimer as a predictor for thrombotic events after renal biopsy. 400 consecutive native renal biopsies were prospectively included in this 2-month follow-up study. The overall incidence of bleeding and thrombotic complication is 4%, including hematuria or large perinephric hematoma (2.5%, n = 10) and thrombotic complication (1.5%, n = 6). Compared to low serum D-dimer (<2.00 μg/ml), subjects in the group of high serum D-dimer (≥2.00 μg/ml) were more incline to develop thrombotic complications (9.1% versus 0.3%; RR, 30.33; p < 0.001). D-dimer correlated positively with age (rs = 0.258, P < 0.001). Inverse correlations were found for albumin (rs = −0.339, P < 0.001). Taken together, patients with high serum D-dimer carry an increased risk of thrombotic complications after renal biopsy. Our findings suggest that serum D-dimer can serve as a potential predictor for thrombotic events in patients with kidney disease. Further cautions should be given to these subjects.

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“…In addition, the level of serum magnesium 56 and levels of serum D-dimer 65 were studied and found to be associated with treatment failure and relapse.…”

Section: Risk Factors For Relapse and Failure Of Aecopdmentioning

confidence: 99%

Acute exacerbations of COPD: risk factors for failure and relapse

Mantero¹,

Rogliani²,

Pasquale³

et al. 2017

COPD

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Acute exacerbations are a leading cause of worsening COPD in terms of lung function decline, quality of life, and survival. They also have a relevant economic burden on the health care system. Determining the risk factors for acute exacerbation and early relapse could be a crucial element for a better management of COPD patients. This review analyzes the current knowledge and underlines the main risk factors for recurrent acute exacerbations. Comprehensive evaluation of COPD patients during stable phase and exacerbation could contribute to prevent treatment failure and relapses.

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Prognostic role of D-dimer for in-hospital and 1-year mortality in exacerbations of COPD

Cited by 32 publications

References 32 publications

Establishment of risk prediction model and risk score for in‐hospital mortality in patients with AECOPD

Establishment of risk prediction model and risk score for in‐hospital mortality in patients with AECOPD

Serum D-dimer is a potential predictor for thromboembolism complications in patients with renal biopsy

Acute exacerbations of COPD: risk factors for failure and relapse

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