Prognostic role of cyclin B1 in solid tumors: a meta-analysis

Ye, Chenyang; Wang, Ji; Wu, Pin; Li, Xiaofen; Chai, Ying

doi:10.18632/oncotarget.13653

Cited by 47 publications

(38 citation statements)

References 41 publications

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“…After 34 studies were excluded according to our including criteria, eventually a total of 12 articles (2080 patients) were included for analysis and evaluation, of which 11 articles [ 14 – 20 , 22 – 25 ] including 1971 patients were included for analyzing the correlation of positive/high expression of cyclin B1 and OS, 9 studies [ 15 – 17 , 19 , 21 – 25 ] including 1253 participants for analyzing the correlation between cyclin B1 and clinicopathological features (Figure 1 ). The excluding reasons were as follows: 32 studies for lack of available data; 1 study [ 26 ] for the definition of positive/high expression did not meet our including criteria; 1 study [ 27 ] was just a review article with no available data. Of the included studies, six were conducted in Japan, three in China, each one in Brazil, Germany and Korea.…”

Section: Resultsmentioning

confidence: 99%

The prognostic significance of high/positive expression of cyclin B1 in patients with three common digestive cancers: a systematic review and meta-analysis

Wen

Cao

Lian³

et al. 2017

Oncotarget

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Recently, several studies have reported that the expression of cyclin B1 may be associated with the prognosis of cancer. Nevertheless, their conclusions were still controversial. The present was designed to analyze and evaluate the prognostic role of cyclin B1 expression in patients with digestive cancer. PubMed, Embase, Cochrane Library and Web of Science were searched to January, 2017. Pooled odds ratio (OR) with 95% confidence intervals (CIs) were estimated. For the pooled OR estimates of OS, we performed subgroup analysis. Besides, sensitivity analysis was performed to examine the stability of the combined results. All statistical analyses were performed using standard statistical procedures provided in RevMan 5.2. A total of 12 studies (N = 2080 participants) were included for this meta-analysis. The positive/high expression of cyclin B1 had an obvious association with both 3-year overall survival (OR 0.21, 95% CI 0.12–0.37; P < 0.00001) and 5-year overall survival (OR 0.20, 95% CI 0.12–0.34; P < 0.00001) in esophageal cancer, and 5-year overall survival of colorectal cancer (OR 2.01, 95% CI 1.32–3.08; P = 0.001). This meta-analysis indicated that positive/high expression of cyclin B1 may have a close association with worse survival in patients with esophageal cancer, but better prognosis in patients with colorectal cancer.

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Section: Resultsmentioning

confidence: 99%

The prognostic significance of high/positive expression of cyclin B1 in patients with three common digestive cancers: a systematic review and meta-analysis

Wen

Cao

Lian³

et al. 2017

Oncotarget

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“…We also found that CCNB1 is required for cell cluster rotation (Figure ). A previous meta‐analysis showed that the contribution of CCNB1 expression in solid tumors to prognosis is controversial . Western blot and mRNA expression analyses indicated that the elevated expression was negatively associated with lymph node metastasis, distant metastasis stage and TNM stage in CRC .…”

Section: Discussionmentioning

confidence: 99%

“…A previous meta-analysis showed that the contribution of CCNB1 expression in solid tumors to prognosis is controversial. 1,51,52 Western blot and mRNA expression analyses indicated F I G U R E 8 Summary of the in vitro model system for collective cell migration at the invasive front. CCNB1, cyclin B1 that the elevated expression was negatively associated with lymph node metastasis, distant metastasis stage and TNM stage in CRC.…”

Section: Discussionmentioning

confidence: 99%

Active K‐RAS induces the coherent rotation of epithelial cells: A model for collective cell invasion in vitro

et al. 2018

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At the invasive front of adenocarcinomas, single cells and multicellular structures exist; the latter include glands and cell clusters, such as tumor buddings and poorly differentiated clusters. Recent reports suggest the importance of collective cell migration in metastasis; however, it is technically difficult to observe the movement of multicellular structures in vivo. We utilized MDCK cells as a model for epithelial cells and established a method to quantify their motility in 3D structures in vitro. A single MDCK cell grows as a cell cluster in the gel and later proliferates and forms a cyst. Active K‐RAS expression induced rotation of both the cell clusters and the cysts. The rotation speed of cell clusters was 4 times higher than that of cysts. The screening of inhibitors for their effects on cell clusters and cysts revealed that cyclin B1 and β‐catenin were the key molecules for their rotation, respectively. Regulators for cyst rotation, such as vorinostat and β‐catenin, were not effective for inducing cell cluster rotation. These results indicate that the signaling pathways of cell dynamics are different between cell clusters and cysts. As cell clusters are related to lymph node involvement and the prognosis of various carcinomas, our in vitro quantitative system may be useful for the screening of drugs to prevent lymphatic invasion.

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“…A meta-analysis revealed that overexpression of cyclinB1 was associated with poor survival in patients with most types of solid tumors, suggesting that the expression of cyclinB1 is an important parameter for prognosis in this setting. 11 It was found that the expression of cyclinB1 was higher in malignant specimens than in benign cases, suggesting that cyclinB1 can be used as an effective marker for the differentiation of benign and For personal use only. malignant thyroid tumors.…”

Section: Discussionmentioning

confidence: 99%

<p>Inhibition of cyclinB1 Suppressed the Proliferation, Invasion, and Epithelial Mesenchymal Transition of Hepatocellular Carcinoma Cells and Enhanced the Sensitivity to TRAIL-Induced Apoptosis</p>

Lv¹,

Ning²,

Li³

et al. 2020

OTT

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Background: CyclinB1 is highly expressed in various tumor tissues and plays an important role in tumor progression. However, its role in hepatocellular carcinoma (HCC) remains unclear. Therefore, the aim of this study was to explore the role of cyclinB1 in the development and progression of HCC. Methods: The expression of cyclinB1 was analyzed using the Gene Expression Profiling Interactive Analysis (GEPIA) database, and detected in HCC tissues and HCC cell lines through quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Western blotting. CyclinB1-short hairpin RNA (Sh-cyclinB1) was transfected into HCC cells to knockdown cyclinB1, and the effect of cyclinB1 knockdown on HCC was examined via the MTT assay, colony formation assay, wound healing assay, scratch assay, cell cycle analysis in vitro, and xenograft model in nude mice. In addition, the role of cyclinB1 on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis was measured using flow cytometry and Western blotting. Results: The GEPIA database analysis showed that cyclinB1 was highly expressed in HCC tissues. The results of qRT-PCR and Western blotting proved that the expression of cyclinB1 was significantly increased in HCC tissues and cell lines. The data of the MTT assay, colony formation assay, and cell cycle analysis indicated that cyclinB1 knockdown inhibited the proliferation of HCC cells. In addition, cell migration, invasion, and epithelial mesenchymal transition were also impaired by cyclinB1 knockdown. Furthermore, the xenograft model in nude mice demonstrated that inhibition of cyclinB1 suppressed tumor growth and metastasis in vivo. Finally, the results of flow cytometry and Western blotting indicated that inhibition of cyclinB1 enhanced the sensitivity of HCC cells to TRAIL-induced apoptosis. Conclusion: Overall, these data provide reasonable evidence that cyclinB1 may serve as a proto-oncogene during the progression of HCC.

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Prognostic role of cyclin B1 in solid tumors: a meta-analysis

Cited by 47 publications

References 41 publications

The prognostic significance of high/positive expression of cyclin B1 in patients with three common digestive cancers: a systematic review and meta-analysis

The prognostic significance of high/positive expression of cyclin B1 in patients with three common digestive cancers: a systematic review and meta-analysis

Active K‐RAS induces the coherent rotation of epithelial cells: A model for collective cell invasion in vitro

<p>Inhibition of cyclinB1 Suppressed the Proliferation, Invasion, and Epithelial Mesenchymal Transition of Hepatocellular Carcinoma Cells and Enhanced the Sensitivity to TRAIL-Induced Apoptosis</p>

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