Prognostic Role of Aryl Hydrocarbon Receptor Interacting Protein (AIP) Immunohistochemical Expression in Patients with Resected Gastric Carcinomas

Arco, Cristina Díaz del; Muñoz, Lourdes Estrada; Manchado, Rodrigo Barderas; García, Ana Elvira González; Ortega, Luís; Roldán, Elena Molina; Fernández, Guillermo Solís; Heras, Soledad García Gómez de las; Aceñero, María Jesús Fernández

doi:10.1007/s12253-020-00863-7

Cited by 5 publications

(8 citation statements)

References 32 publications

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“…However, AIP mutation's analysis in colorectal, breast and prostate cancer showed that the presence of somatic mutations is not a common finding [41]. In contrast, AIP overexpression in tumors has been strongly associated with a poor outcome in gastric [42], pancreatic [43] and colorectal cancer patients (here presented data). Notably, AIPinduced alterations in the EMT process have been previously reported.…”

Section: Discussionmentioning

confidence: 50%

Aryl-hydrocarbon receptor-interacting protein regulates tumorigenic and metastatic properties of colorectal cancer cells driving liver metastasis

et al. 2022

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BACKGROUND: Liver metastasis is the primary cause of colorectal cancer (CRC)-associated death. Aryl-hydrocarbon receptorinteracting protein (AIP), a putative positive intermediary in aryl-hydrocarbon receptor-mediated signalling, is overexpressed in highly metastatic human KM12SM CRC cells and other highly metastatic CRC cells. METHODS: Meta-analysis and immunohistochemistry were used to assess the relevance of AIP. Cellular functions and signalling mechanisms mediated by AIP were assessed by gain-of-function experiments and in vitro and in vivo experiments. RESULTS: A significant association of high AIP expression with poor CRC patients' survival was observed. Gain-of-function and quantitative proteomics experiments demonstrated that AIP increased tumorigenic and metastatic properties of isogenic KM12C (poorly metastatic) and KM12SM (highly metastatic to the liver) CRC cells. AIP overexpression dysregulated epithelial-tomesenchymal (EMT) markers and induced several transcription factors and Cadherin-17 activation. The former induced the signalling activation of AKT, SRC and JNK kinases to increase adhesion, migration and invasion of CRC cells. In vivo, AIP expressing KM12 cells induced tumour growth and liver metastasis. Furthermore, KM12C (poorly metastatic) cells ectopically expressing AIP became metastatic to the liver. CONCLUSIONS: Our data reveal new roles for AIP in regulating proteins associated with cancer and metastasis to induce tumorigenic and metastatic properties in colon cancer cells driving liver metastasis.

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Section: Discussionmentioning

confidence: 50%

Aryl-hydrocarbon receptor-interacting protein regulates tumorigenic and metastatic properties of colorectal cancer cells driving liver metastasis

et al. 2022

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“…Loss of function AIP mutations have widely been associated with pituitary adenomas, suggesting that AIP is a tumor suppressor in the pituitary gland ( 7 ). However, AIP can function as an oncogene in DLBCL and various cancers of the gastrointestinal tract ( 17 , 18 , 19 , 20 ). These studies highlight cell-specific roles of AIP in either the prevention or promotion of tumorigenesis.…”

Section: Aip In Tumorigenesismentioning

confidence: 99%

“…Elevated AIP expression has been associated with a worse prognosis of several carcinomas of the gastrointestinal tract, including cholangiocarcinoma, pancreatic carcinoma, gastric carcinoma, and colorectal cancer ( 17 , 18 , 20 ). While these studies mainly found a correlation between AIP expression and carcinogenesis, rather than AIP activity, they nevertheless suggest that AIP may act as an oncogene in the gastrointestinal tract.…”

Section: Aip In Non-endocrine Tumorsmentioning

confidence: 99%

“…Another study examined AIP expression in 147 cases of gastric cancer, and 36.6% of the tumors had high AIP expression ( 18 ). AIP staining was cytoplasmic in most of the tumors.…”

Section: Aip In Non-endocrine Tumorsmentioning

confidence: 99%

“…These tumors tend to be more aggressive, with large and invasive pituitary adenomas that display resistance to somatostatin analog treatment ( 7 ). In addition to endocrine tumors, AIP mutations have also been associated with several other types of cancer, including colorectal cancer, gastric carcinoma, pancreatic carcinoma, and diffuse large B-cell lymphoma ( 16 , 17 , 18 , 19 ).…”

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confidence: 99%

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The aryl hydrocarbon receptor-interacting protein in cancer and immunity: Beyond a chaperone protein for the dioxin receptor

Kazzaz,

Tawil,

Harhaj

2024

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Mutations in the N-domain of aryl hydrocarbon receptor interacting protein affect interactions with heat shock protein 90β and phosphodiesterase 4A5

Vella,

Manfield,

Seychell

et al. 2024

Biochimie

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Prognostic Role of Aryl Hydrocarbon Receptor Interacting Protein (AIP) Immunohistochemical Expression in Patients with Resected Gastric Carcinomas

Cited by 5 publications

References 32 publications

Aryl-hydrocarbon receptor-interacting protein regulates tumorigenic and metastatic properties of colorectal cancer cells driving liver metastasis

Aryl-hydrocarbon receptor-interacting protein regulates tumorigenic and metastatic properties of colorectal cancer cells driving liver metastasis

The aryl hydrocarbon receptor-interacting protein in cancer and immunity: Beyond a chaperone protein for the dioxin receptor

Mutations in the N-domain of aryl hydrocarbon receptor interacting protein affect interactions with heat shock protein 90β and phosphodiesterase 4A5

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