Prognostic role of anemia in heart failure with preserved ejection fraction: A systematic review and meta-analysis

Majmundar, Monil; Doshi, Rajkumar; Zala, Harshvardhan; Shah, Prasun; Adalja, Devina; Shariff, Mariam; Kumar, Ashish

doi:10.1016/j.ihj.2021.06.011

Cited by 6 publications

(5 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Timely corrections of anemia is crucial in reducing mortality and anemia related complications in patients with ADHF. Most of the patients (nearly >60%) at the time of hospitalization document anemia [23][24][25]. These findings are consistent with our study findings where more than 68% of our study subjects had anemia.…”

Section: Discussionsupporting

confidence: 92%

Frequency of Anemia in Patients Admitted with Acute Decompensated Heart Failure in Tertiary Care Cardiac Hospital

Bhuromal

Memon

Shaikh

et al. 2022

JPRI

View full text Add to dashboard Cite

Introduction: Anemia is one of the potential comorbid condition in patients with acute decompensated heart failure (ADHF) which is linked to higher morbidity and mortality rates. Worldwide, its prevalence ranges from 4% to >70% in hospitalized patients with ADHF. Unfortunately data is lacking from our region and hence we aimed to conduct this study to scientifically fill the present gap by evaluating the actual burden of anemia in patients hospitalized with ADHF in a tertiary care hospital of Karachi, Pakistan. Patients and Methods: This was a hospital based study conducted in the Department of Cardiology, Tabba Heart Institute, Karachi From 1st November 2019 to 30th April 2020. A total of 203 patients with ADHF with age >35 years and <80 years were selected. A blood sample was taken to determine the hemoglobin levels and hemoglobin (Hb) levels <12.0 g/dL in women and <13.0 g/dL in men were taken as cut-off for anemia. Results: Overall mean and SD of age was 63.70±10.53 years and among them most of were males (n = 116, 57.1%). The overall prevalence of anemia in patients with ADHF was quite high and 63.5% (n = 129). Only three condition, hypertension, diabetes mellitus, and current smoking habits had significant association with the occurrence of anemia in patients with ADHF, p value <0.05. Conclusion: In conclusion, the results showed that anemia is an independent risk for HF. Anemia was observed in one-third of the study population. More prevalent in male gender, elderly patients of age above 60 years, and associated with other comorbids.

show abstract

Section: Discussionsupporting

confidence: 92%

Frequency of Anemia in Patients Admitted with Acute Decompensated Heart Failure in Tertiary Care Cardiac Hospital

Bhuromal

Memon

Shaikh

et al. 2022

JPRI

View full text Add to dashboard Cite

show abstract

“…3 The presence of anemia has significant associations with increased morbidity, all-cause hospitalizations, and all-cause mortality in adults. 4 Serious adverse effects associated with anemia are observed in patients with heart failure with preserved ejection fraction, 5,6 and the presence of anemia status is a valuable prognostic indicator in several serious diseases, including soft tissue sarcomas 7 and heart failure. 6 Some older data suggest that the prevalence of anemia is rising in the general population of the United States.…”

Section: Introductionmentioning

confidence: 99%

Anemia prevalence time trends and disparities in the US population: examination of NHANES 1999–2020

Hwang

Ahuja

Haque

et al. 2023

Journal of Investigative Medicine

View full text Add to dashboard Cite

While a rising prevalence of anemia in the United States was reported in older studies, recent data are lacking. To estimate the prevalence and time trends of anemia in the United States and to examine how these estimates differ by gender, age, race, and household income to poverty threshold ratio (HIPR), we used the National Health and Nutrition Examination Surveys from 1999 to 2020. The presence of anemia was determined using the World Health Organization criteria. Survey-weighted raw and adjusted prevalence ratios (PRs) were determined using generalized linear models for the overall population and by gender, age, race, and HIPR. In addition, an interaction between gender and race was explored. Complete data on anemia, age, gender, and race were available on 87,554 participants (mean age = 34.6 years, women = 49.8%, Whites = 37.3%). Anemia prevalence increased from 4.03% during the 1999–2000 survey cycle to 6.49% during 2017–2020. In adjusted analyses, anemia prevalence was higher in >65 than in 26–45 years old (PR = 2.14, 95% confidence interval (CI) = 1.95, 2.35), in Blacks than Whites (PR = 3.97, 95% CI = 3.63, 4.35), in women than men (PR = 1.98, 95% CI = 1.83, 2.13), and in those with HIPR ≤ 1 than >4 (PR = 0.68, 95% CI = 0.61, 0.75). Gender modified the relationship between anemia and race; when compared to their male counterparts, Black, Hispanic, and other women had higher anemia prevalence than White women (all interaction p values <0.05). The anemia prevalence in the United States has risen from 1999 to 2020 and remains high among the elderly, minorities, and women. The difference in anemia prevalence between men and women is larger in non-Whites.

show abstract

“…Once again, anemia was identified as a risk factor for all-cause mortality in the Swedish-HF study [23], lending support to our findings. In a comprehensive meta-analysis of 28,735 patients by Majmundar et al, anemia was found to be a prognostic factor for all-cause mortality and all-cause hospitalizations in patients with HFpEF [24]. Furthermore, other studies have shown that anemia substantially raises mortality rates in patients with HFpEF [25][26][27].…”

Section: Discussionmentioning

confidence: 97%

Anemia and Iron Deficiency Predict All-Cause Mortality in Patients with Heart Failure and Preserved Ejection Fraction: 6-Year Follow-Up Study

Köseoğlu,

Özlek

2024

Diagnostics

View full text Add to dashboard Cite

Aims: The aim of this study was to assess the prevalence of anemia and iron deficiency in patients with heart failure with preserved ejection fraction (HFpEF) and its impact on clinical outcomes. Methods: We retrospectively analyzed 212 patients with HFpEF and identified anemia as a serum hemoglobin level of less than 13 g/dL in men and less than 12 g/dL in women. Additionally, ID was defined as a serum ferritin concentration < 100 ng/mL or 100–299 ng/mL with transferrin saturation < 20%. Patients were followed up for an average of 66.2 ± 12.1 months, with the endpoint being all-cause mortality among patients with HFpEF, both with and without anemia and iron deficiency. Furthermore, we explored other predictors of all-cause mortality. Results: The average age of the entire group was 70.6 ± 10.5 years, with females comprising 55% of the patients. Anemia was present in 81 (38.2%) patients, while 108 (50.9%) had iron deficiency. At the end of the follow-up period, 60 (28.3%) of the patients had passed away. Patients with anemia displayed more heart failure (HF) symptoms, diastolic dysfunction, higher NT-pro-BNP levels, and worse baseline functional capacity than those without. Similarly, patients with iron deficiency showed more pronounced HF symptoms and worse functional capacity than those without. The results from the multivariable analyses revealed that anemia (hazard ratio [HR]: 5.401, 95% confidence interval [CI]: 4.303–6.209, log-rank p = 0.001), advanced age, iron deficiency (HR: 3.502, 95% CI: 2.204–6.701, log-rank p = 0.015), decreased left ventricular ejection fraction, chronic kidney disease, and paroxysmal nocturnal dyspnea were all independently associated with all-cause mortality. Conclusions: It is essential to consider anemia and iron deficiency as common comorbidities in managing and prognosis HFpEF, as they significantly increase mortality risk.

show abstract

Prognostic role of anemia in heart failure with preserved ejection fraction: A systematic review and meta-analysis

Cited by 6 publications

References 13 publications

Frequency of Anemia in Patients Admitted with Acute Decompensated Heart Failure in Tertiary Care Cardiac Hospital

Frequency of Anemia in Patients Admitted with Acute Decompensated Heart Failure in Tertiary Care Cardiac Hospital

Anemia prevalence time trends and disparities in the US population: examination of NHANES 1999–2020

Anemia and Iron Deficiency Predict All-Cause Mortality in Patients with Heart Failure and Preserved Ejection Fraction: 6-Year Follow-Up Study

Contact Info

Product

Resources

About