Prognostic role and clinical significance of C-reactive protein-lymphocyte ratio in colorectal cancer

Meng, Yongsheng; Long, Chenyan; Huang, Xiaoliang; Huang, Lihaoyun; Liao, Lixian; Tang, Weizhong; Liu, Jungang

doi:10.1080/21655979.2021.1960768

Cited by 12 publications

(12 citation statements)

References 33 publications

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“…According to a study which observed CLR in oral malignancy, elevated level of CLR was associated with better prognostic performance compared to other inflammatory markers in subjects with squamous cell carcinoma 11 . Similarly, Meng et al investigated CLR in patients with colorectal cancer and reported that patients with high CLR had shorter overall survival than those with low CLR levels 12 . Subsequently, Mungan et al 13 confirmed the results of Meng et al 12 .…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Meng et al investigated CLR in patients with colorectal cancer and reported that patients with high CLR had shorter overall survival than those with low CLR levels 12 . Subsequently, Mungan et al 13 confirmed the results of Meng et al 12 . In addition, prognostic value of elevated CLR has also been shown in patients with osteosarcoma 14 , cholangiocarcinoma 15 , and lung cancer 16 .…”

Section: Discussionmentioning

confidence: 99%

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C-reactive protein to lymphocyte count ratio is a promising novel marker in hepatitis C infection: the clear hep-c study

Demirkol

Aktas

Bilgin

et al. 2022

Rev. Assoc. Med. Bras.

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OBJECTIVE: Chronic hepatitis C (CHC) is one of the most important health problems affecting the significant rate of world population and it may lead to cirrhosis and hepatocellular carcinoma. C-reactive protein to lymphocyte count ratio (CLR) is used in estimating inflammatory burden. Therefore, this study aimed to compare CLR values between CHC patients and healthy controls and between CHC patients with and without fibrosis. METHODS: Patients with CHC infection who visited outpatient and inpatient internal medicine clinics of our institution between January 2021 and December 2021 were enrolled to this retrospective study. CLR of the patients with CHC and healthy controls were compared. We further compared CLR of CHC patients with and without fibrosis. RESULTS: Median CLR of CHC and control subjects was 2.61 (5.13%) and 0.31 (0.37%), respectively. CLR of the CHC group was significantly increased compared to the CLR of the controls (p<0.001). There was a significant positive correlation between CLR and APRI score (r=0.15, p=0.04). The sensitivity and specificity of CLR in determining CHC above 0.58% level were 84% and 82%, respectively (AUC: 0.884, p<0.001, 95%CI 0.84-0.93). In subgroup analysis, CLR was 3.97 (6.6%) for CHC patients with fibrosis and 1.7 (4.4%) for CHC subjects without fibrosis (p=0.001). CONCLUSIONS: Increased CLR in patients with CHC may be an alarming finding of liver fibrosis, as CLR is associated with both CHC and hepatic fibrosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

C-reactive protein to lymphocyte count ratio is a promising novel marker in hepatitis C infection: the clear hep-c study

Demirkol

Aktas

Bilgin

et al. 2022

Rev. Assoc. Med. Bras.

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“…The included studies were published in 2019-2021, 8 conducted in Japan and 2 in China.All 10 studies reported the relationship between LCR and OS, and 5 studies reported the relationship between LCR and DFS. Eight of them defined LCR as lymphocytes/C-reactive protein ratio, while the other two used Creactive protein/lymphocytes ratio (CLR) (24,29).The study by Taniai et al could be used for OS and DFS analysis after data extraction, while the study by Yongsheng Meng et al could not extract OS outcome data but could be used for analysis of pathological characteristics factors and was therefore included. The LCR threshold values ranged from 5000 to 15923.…”

Section: Basic Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Since tumor patients have both inflammatory infections and immune disorders after surgery, and CRP and lymphocyte levels precisely also reflect well the inflammatory infections and immune status of patients after surgery, a series of studies on colorectal cancer patients in recent years have defined the ratio of lymphocytes to CRP as a new index and reported the correlation between LCR and prognosis of colorectal cancer (20)(21)(22)(23)(24)(25)(26)(27)(28)(29). However, the findings of the studies are not uniform and the cut-off values for this index are not consistent; therefore, this study used Meta-analysis to objectively and systematically investigate the prognostic significance of treatment LCR levels in colorectal cancer patients and the relationship between LCR and the clinicopathological characteristics of colorectal cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Role of Lymphocyte-C-Reactive Protein Ratio in Colorectal Cancer: A Systematic Review and Meta Analysis

et al. 2022

Front. Oncol.

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IntroductionThe lymphocyte-C-reactive protein ratio (LCR) is a new immunoinflammatory score and prognostic marker, but the relationship between this index and the prognosis of colorectal cancer patients remains controversial.Therefore, aim of the study was to assess the relationship between LCR and prognosis for colorectal cancer patients through a systematic evaluation and meta-analysis.MethodsWe systematically searched PubMed, EMBASE, Web of Science, and Cochrane Library databases for randomized controlled studies and observational studies on the relationship between LCR and prognosis of colorectal cancer patients, all searched from the date of database creation to January 6, 2022.Our primary endpoints observed were overall survival (OS) and disease-free survival (DFS) of colorectal cancer patients, and secondary observables were basic characteristics of included studies, such as country, study duration, sample size, LCR threshold, and pathological characteristics of patients in each study, such as degree of differentiation, gender, tumor location, T stage, and lymphatic metastasis.ResultsA total of 10 case-control studies including 7068 patients were included. Meta-analysis results showed that overall survival (OS) and disease-free survival (DFS) were worse in colorectal cancer patients with lower levels of LCR (HR=0.44, 95% CI=0.38-0.52, P<0.001; HR=0.56, 95% CI=0.41-0.76, P< 0.001).Subgroup analysis based on country, study length, sample size, and LCR threshold showed that lower levels of LCR were all associated with poorer OS (P < 0.05). Regarding pathological characteristics, patients in the low LCR group were generally poorly differentiated (OR=1.79, 95% CI=1.55-2.07, P<0.001), while there was no significant relationship with gender, tumor location, T stage, and lymphatic metastasis (P>0.05).Discussion/ConclusionLCR can be used as a prognostic marker for colorectal cancer patients, and patients with lower levels of LCR may have a poor prognosis. Due to the limitation of the number and quality of the included studies, the above findings need to be validated by more high-quality studies.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022296563.

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“…Recent studies found significant association between thyroiditis and novel inflammatory and metabolic markers, including red cell distribution width, 2 neutrophil/lymphocyte counts ratio, 3 and uric acid/HDL ratio 4 . Another novel inflammatory marker is CRP/lymphocyte count ratio (CLR) which reported to be related with pancreas malignancy, 5 cancer of the esophagus, 6 appendicitis, 7 and colorectal cancer 8 …”

Section: Introductionmentioning

confidence: 99%

C‐reactive protein to LymphocytE count ratio could be a reliable mArkeR of thyroiditis; the CLEAR‐T study

Demirkol

Aktas

2022

Precision Medical Sciences

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Inflammation of the thyroid gland is referred to as thyroiditis and is associated with inflammation. Recent studies found significant association between thyroiditis and novel inflammatory and metabolic markers, as well as C‐reactive protein (CRP). CRP/lymphocyte count ratio (CLR) is a novel inflammatory marker that associated with various conditions and has not been studied in thyroiditis, yet. We aimed to investigate CRP to lymphocyte count ratio in patients with thyroiditis and to compare to those in healthy subjects. Patients with thyroiditis that presented to internal medicine outpatient clinics of our institution between January 2019 and August 2021 were enrolled to the retrospective study. Healthy volunteers were enrolled as control group. CLR of the thyroiditis and control groups were compared. Median CLR of the thyroiditis and control groups were 3.14 (0.14%–38)% and 0.4 (0.03–8.86)%, respectively (p < .001). The sensitivity and specificity of CLR > 0.43% in detecting thyroiditis were 92% and 58%, respectively (AUC: 0.88, p < .001, 95% CI: 0.85–0.92).CLR was significantly and positively correlated with free T4 (FT4) (r = .18, p < .001) and inversely correlated with thyroid stimulating hormone (TSH) (r = −.52, p = .003) levels. In conclusion, we suggest that high CLR levels may yield additional diagnostic value in patients with thyroiditis.

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Prognostic role and clinical significance of C-reactive protein-lymphocyte ratio in colorectal cancer

Cited by 12 publications

References 33 publications

C-reactive protein to lymphocyte count ratio is a promising novel marker in hepatitis C infection: the clear hep-c study

C-reactive protein to lymphocyte count ratio is a promising novel marker in hepatitis C infection: the clear hep-c study

Prognostic Role of Lymphocyte-C-Reactive Protein Ratio in Colorectal Cancer: A Systematic Review and Meta Analysis

C‐reactive protein to LymphocytE count ratio could be a reliable mArkeR of thyroiditis; the CLEAR‐T study

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