Prognostic relevance of temporal muscle thickness as a marker of sarcopenia in patients with glioblastoma at diagnosis

Muglia, Riccardo; Simonelli, Matteo; Pessina, Federico; Morenghi, Emanuela; Navarria, Pierina; Persico, Paola; Lorenzi, Elena; Dipasquale, Angelo; Grimaldi, Marco; Scorsetti, Marta; Santoro, Armando; Politi, Letterio S.

doi:10.1007/s00330-020-07471-8

Cited by 31 publications

(34 citation statements)

References 30 publications

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“…An et al 24 suggested that sarcopenia might be connected to GBM, and the TMT could be a significant outcome marker for GBM survival based on their analysis. However, in contrast, Muglia et al 25 reported that TMT measurement and glioblastoma prognosis did not show any meaningful relationship in their results, and also needed a larger-scale research to certify the usefulness of TMT in glioma or other malignant brain tumors. As such, the main objective of this study was to analyze whether TMT was an independent predictor of glioma prognosis, and to explore the influence of TMT on the survival of patients with different tumor grades and IDH molecular pathology.…”

Section: Discussionmentioning

confidence: 86%

“…28 In other words, sarcopenia is associated with life expectancy. 29, 30 A few studies have previously reported the survival outcome relationship between TMT and glioblastoma, 6,16,25,31 but its prognostic impact in different grades of gliomas is still unknown. This research revealed the prognostic role of TMT value among gliomas of different grades and IDH subtypes.…”

Section: Discussionmentioning

confidence: 99%

“…However, there was one paper that proposed they did not found any relationship between TMT and survival prognosis in glioblastoma patients. 25 This seemingly paradoxical outcome may be understandable; it is likely that their number of cases was relatively small; only 51 patients were enrolled; thus, the low sample size could restrict the capability to evaluate statistical significance.…”

Section: Discussionmentioning

confidence: 99%

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Temporal Muscle Thickness is an Independent Prognostic Biomarker in Patients with Glioma: Analysis of 261 Cases

Yan¹,

Teng²,

Fu³

et al. 2021

CMAR

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Purpose: Temporal muscle thickness (TMT) has been proposed as a novel surrogate marker for skeletal muscle mass in head and neck malignancies. This study investigated the TMT prognostic relevance with gliomas and evaluated the influence of TMT values on survival in patients with gliomas of different grades and IDH subtypes. Methods: The patients' TMT was measured on contrast-enhanced T1-weighted magnetic resonance images before surgical treatment. Patients were divided into two cohorts based on their median TMT values. The Kaplan-Meier curve was used to compute the overall survival (OS) of different categories and all gliomas. Univariate and multivariate Cox regression analyses were conducted to assess the association between OS and TMT, hematological markers, and other clinical factors in glioma patients. Moreover, the clinical diagnostic efficiency of single and combination biomarkers was evaluated using receiver operating characteristic curve analysis. Results: We retrospectively analyzed 261 patients with newly diagnosed glioma between November 2016 and May 2020 at Hunan Cancer Hospital. Cox analysis indicated that higher TMT (HR 0.286, P< 0.001) and higher KPS score (HR 0.629, P= 0.012) were protective prognostic factors and IDH wildtype status (HR 2.946, P< 0.001), RDW > 12.6 (HR 1.513, P= 0.036), and NLR > 4 (HR 1.560, P= 0.042) were poor prognostic factors for gliomas. Subsequently, patients with thicker TMT were found to have significantly better overall survival (P<0.001) than patients with thinner TMT among WHO III and WHO IV grade and patients with or without IDH mutation. TMT was considered a better single biomarker than recently prevalent hematological biomarkers for predicting high-grade [0.856 (0.797-0.916)] and IDH-wild-type [0.864 (0.786-0.941)] gliomas. Conclusion:This study suggests that TMT is a positive biomarker for clinical prognosis in gliomas and that patients with thicker TMT have greater overall survival for gliomas of different grades and IDH subtypes.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Temporal Muscle Thickness is an Independent Prognostic Biomarker in Patients with Glioma: Analysis of 261 Cases

Yan¹,

Teng²,

Fu³

et al. 2021

CMAR

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“…[ 1 ] On the other hand, Muglia revealed that TMT was not associated with prognosis in his cohort of patients with glioblastoma at diagnosis. [ 30 ] In other studies, the cutoff points of TMT in MRI to diagnose sarcopenia are 6.3 mm for male patients and 5.2 mm for female patients, respectively. [ 39 ] Katsuki reported that the TMT thresholds for the subarachnoid hemorrhage outcome on CT images were 4.9 mm in females and 6.7 mm in males, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, TMT is substituted as a useful and safe measure of the total body skeletal muscle mass. [ 13 , 25 , 33 ] TMT is also featured and reported as clinically useful parameters; they are indicators of nutrition,[ 13 ] prognosis of glioblastoma,[ 1 , 12 , 15 , 26 , 30 , 41 ] and newly diagnosed brain metastasis. [ 10 , 11 ] TMT is a predictor of sarcopenia in neurological patients.…”

Section: Introductionmentioning

confidence: 99%

Standard values for temporal muscle thickness in the Japanese population who undergo brain check-up by magnetic resonance imaging

Katsuki

Narita

Sasaki³

et al. 2021

Surgical Neurology International

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Background: Skeletal muscle mass is an important factor for various diseases’ outcomes. The psoas muscle cross-sectional area on the abdominal computed tomography (CT), gait speed, and handgrip strength is used to measure it. However, it is difficult to measure the neurological patients’ muscle mass or function because (1) we do not perform abdominal CT. (2) Such patients have impaired consciousness, gait disturbance, paresis, and need of rest. Temporal muscle thickness (TMT) on magnetic resonance imaging (MRI) is now attractive for skeletal muscle volume indicator, but the reference values are not established. We herein investigated the standard value of the Japanese TMT using the brain check-up database by MRI. Methods: We retrospectively investigated 360 Japanese individuals from two institutions between 2017 and 2019. We measured TMT on the T1-weighted images in the previously reported way. The associations between TMT and other variables were analyzed. Results: TMT of 214 women and 146 men, ranging from 35 to 84 years old, was investigated. TMT ranged from 3.69 to 16.90 mm. Mean TMT values were significantly higher in men compared to women except for the over 70-year-old cohort. TMT was correlated to weight and body mass index in both sexes. Conclusion: This is the first retrospective study on the standard TMT values from the Japanese brain check-up database. Our results were just reference values, but these would be useful for further investigation in other neurosurgical and neurological diseases regarding muscle volume or sarcopenia.

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Sarcopenia in patients with dementia: correlation of temporalis muscle thickness with appendicular muscle mass

et al. 2021

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Prognostic relevance of temporal muscle thickness as a marker of sarcopenia in patients with glioblastoma at diagnosis

Cited by 31 publications

References 30 publications

Temporal Muscle Thickness is an Independent Prognostic Biomarker in Patients with Glioma: Analysis of 261 Cases

Temporal Muscle Thickness is an Independent Prognostic Biomarker in Patients with Glioma: Analysis of 261 Cases

Standard values for temporal muscle thickness in the Japanese population who undergo brain check-up by magnetic resonance imaging

Sarcopenia in patients with dementia: correlation of temporalis muscle thickness with appendicular muscle mass

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