Prognostic relevance of superoxide dismutases in gastric cancer

Janssen, A. Miranda L.; Bosman, C; Kubben, F. J. G. M.; Duijn, Wim van; Ruit, M.M. Oostendorp-van de; Griffioen, G.; Lamers, C. B. H. W.; Verspaget, Hein W.

doi:10.1016/s0016-5085(98)82515-8

Cited by 3 publications

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“…Significantly higher SOD2 levels have been found in leukemia [23] and ovarian cancer [24], suggesting increased SOD2 activity was required for defense against ROS stress-induced injury and apoptosis [9]. In gastric cancer, elevated levels of SOD2 activity, mRNA and protein have been found to be associated with the aggressiveness of tumor and poor survival [25][26][27][28][29]. The Ala variant of SOD2 rs4880 is more active than the Val variant, sug-gesting that the homozygous CC genotype may present higher enzymatic activity than its TT counterpart [30].…”

Section: Discussionmentioning

confidence: 99%

SOD2 rs4880 CT/CC genotype to predict poor survival for Chinese gastric cancer patients received platinum and fluorouracil based adjuvant chemotherapy.

Chen²,

Lee

et al. 2015

JCO

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Adjuvant chemotherapy is a standard therapy for gastric cancer patients, however, treatment response is quite heterogeneous. Molecular biomarkers will be highly valuable to guide the therapy and predict the response and prognosis in these patients. The antioxidant enzymes superoxide dismutase 2 (SOD2) and glutathione S-transferase pi 1 (GSTP1) are involved in oxidative stress and drug detoxification, which modulate the efficacy of anticancer drugs. Here, we investigated the clinical associations of two functional single nucleotide polymorphisms of SOD2 and GSTP1 in stage II-III postoperative gastric cancer patients. SOD2 rs4880 and GSTP1 rs1695 were genotyped in 207 patients received postoperative platinum and fluorouracil based chemotherapy and 304 patients who did not. SOD2 rs4880 CT/CC significantly associated with decreased median overall survival time of 23 months when compared to the TT genotype (mean overall survival time of 65.2 months, P=0.002) only for patients received adjuvant chemotherapy. Stratification analysis showed SOD2 rs4880 CT/CC affected most significantly the clinical outcome for patients with tumor arising at gastric body (HR, 5.707, P=0.002), well to moderately differentiated adenocarcinoma (HR, 4.900, P<0.001), tumor of intestinal type (HR, 4.398, P<0.001), or tumor size less or equal to 5 cm (HR, 2.490, P=0.004); while GSTP1 rs1695 GA/GG was significant decreased overall survival time among patients with tumor arising at fundus or cardia (HR, 3.001, P=0.004), or mucinous or signet-ring cell carcinoma (HR, 4.750, P=0.042). The present study suggested the two polymorphisms would affect the adjuvant chemotherapy outcome in specific subtype of gastric cancer. SOD2 rs4880 could be used as a biomarker to predict the prognosis and response to therapy.

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Section: Discussionmentioning

confidence: 99%

SOD2 rs4880 CT/CC genotype to predict poor survival for Chinese gastric cancer patients received platinum and fluorouracil based adjuvant chemotherapy.

Chen²,

Lee

et al. 2015

JCO

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“…Τα χαρακτηριστικά τους αυτά τις καθιστούν αποτελεσµατικούς αναστολείς της υπεροξείδωσης των λιπιδίων, ενώ η πυρηνική τους εντόπιση προστατεύει το DNA από οξειδωτική βλάβη και το κύτταρο από τον αποπτωτικό θάνατο(238)(239)(240). Μελέτες της έκφρασης των µεταλλοθειονινών στο φυσιολογικό εντερικό επιθήλιο, έδειξαν ότι οι πρωτεΐνες αυτές εκφράζονται τόσο στο κυτταρόπλασµα όσο και στον πυρήνα των εντεροκυττάρων που καλύπτουν τη λάχνη, αλλά και στο επιθήλιο των κρυπτών(241)(242)(243). Η σύνθεσή τους σχετίζεται µε τα επίπεδα ψευδαργύρου στο κύτταρο και ρυθµίζεται θετικά από διάφορες κυτταροκίνες (IL-1, IL-6, TNF-α, INF-γ) (236).…”

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Εντερική Διαπερατότητα Στον Πειραματικό Αποφρακτικό Ίκτερο

Ασημακόπουλος¹

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Κυτταρικές και βιοχηµικές µεταβολές του εντερικού βλεννογόνου και επίδραση των ρυθµιστικών εντερικών πεπτιδίων Bombesin και Neurotensin Υπό ΣΤΥΛΙΑΝΟΥ Φ. ΑΣΗΜΑΚΟΠΟΥΛΟΥ ΙΑΤΡΟΥ ΠΑΤΡΑ 2004 2 3 ΤΡΙΜΕΛΗΣ ΣΥΜΒΟΥΛΕΥΤΙΚΉ ΕΠΙΤΡΟΠΗ Σκόπα Χρυσούλα, Αναπλ. Καθηγήτρια Παθολογικής Ανατοµικής (επιβλέπουσα) Βαγιανός Κωνσταντίνος, Αναπλ. Καθηγητής Χειρουργικής (µέλος) Νικολοπούλου Βασιλική, Αναπλ. Καθηγήτρια Γαστρεντερολογίας (µέλος)

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Attenuated mild colonic inflammation and improved survival from severe DSS-colitis of transgenic Cu/Zn-SOD mice

Kruidenier

2003

Free Radical Biology and Medicine

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Prognostic relevance of superoxide dismutases in gastric cancer

Cited by 3 publications

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SOD2 rs4880 CT/CC genotype to predict poor survival for Chinese gastric cancer patients received platinum and fluorouracil based adjuvant chemotherapy.

SOD2 rs4880 CT/CC genotype to predict poor survival for Chinese gastric cancer patients received platinum and fluorouracil based adjuvant chemotherapy.

Εντερική Διαπερατότητα Στον Πειραματικό Αποφρακτικό Ίκτερο

Attenuated mild colonic inflammation and improved survival from severe DSS-colitis of transgenic Cu/Zn-SOD mice

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