Prognostic Relevance of hMLH1, hMSH2, and BAX Protein Expression in Endometrial Carcinoma

Peiró, Gloria; Diebold, Joachim; Mayr, Doris; Baretton, Gustavo; Schmidt, Michael; Löhrs, U.

doi:10.1038/modpathol.3880389

Cited by 16 publications

(9 citation statements)

References 38 publications

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“…11,12 In our study, significant correlations were found between a loss of nuclear expression of hMLH1 protein and a lower histological grade and lymph-vascular space invasion (LVI) in SEEA. However, we saw no apparent correlation between the loss of hMSH2 protein expression and clinicopathological factors like patient age, tumor grade, LVI, or myometrial invasion (P > 0.05).…”

Section: Discussionmentioning

confidence: 74%

“…[2][3][4][5][6][7][8][9][10][11][12], BAT26 (within intron 5 of the hMSH2 gene), and BAT25 (in an intron of the c-kit oncogene on chromosome 4q12), by following the recommendations of the National Cancer Institute Workshop. 14 These reference markers were used to identify tumors characterized by defective MMR, primarily in the two major MMR genes hMLH1 and hMSH2.…”

Section: Dna Extraction Microsatellite Markers and Microsatellite Imentioning

confidence: 99%

“…8,9 Many research efforts to date have been aimed at investigating the prevalence and the biologic relevance of MSI, whereas its possible prognostic roles are far from being clarified. 10,11 A small number of studies have suggested that there is a correlation between loss of hMLH1 and survival in endometrial carcinoma, 11,12 and ovarian cancer. 13 Nonetheless, the mechanisms underlying these associations have yet to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

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Loss of hMLH1 expression is associated with less aggressive clinicopathological features in sporadic endometrioid endometrial adenocarcinoma

Park

Lee³

et al. 2006

J of Obstet and Gynaecol

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Section: Discussionmentioning

confidence: 74%

Section: Dna Extraction Microsatellite Markers and Microsatellite Imentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Loss of hMLH1 expression is associated with less aggressive clinicopathological features in sporadic endometrioid endometrial adenocarcinoma

Park

Lee³

et al. 2006

J of Obstet and Gynaecol

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“…[2][3][4][5] Similarly, other studies have also shown a more frequent loss of hMLH1 expression compared with loss of hMSH2 expression. 2,3,5,25 Despite the importance of hMLH1 in microsatellite instability, the presence of normal hMLH1 expression in 53% of the microsatellite instability-high tumors in our study suggested the involvement of other DNA mismatch repair genes as well, such as hPMS1, hPMS2, hMSH3, and hMSH6. 1 A major mechanism for loss of hMLH1 expression in sporadic colon and endometrial cancers was hypermethylation of the hMLH1 promoter, resulting in silencing of the hMLH1 gene.…”

Section: Discussionmentioning

confidence: 88%

Microsatellite instability and expression of hMLH1 and hMSH2 proteins in ovarian endometrioid cancer

et al. 2004

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Microsatellite instability and loss of heterozygosity has been implicated in ovarian carcinogenesis. The reported frequency of microsatellite instability in human ovarian cancer varies significantly owing to the use of heterogeneous tumor histotypes and various microsatellite markers in different laboratories. In this study, we determined the frequency of microsatellite instability in 74 ovarian endometrioid carcinomas using four microsatellite markers (BAT25, BAT26, D5S346, D17S250), and examined hMLH1 and hMSH2 protein expression. In all, 20% of the tumors were microsatellite instability high (two or more markers showing instability) and 12% were microsatellite instability low (one marker showed instability). Loss of hMLH1 and/or hMSH2 expression was found in nine of 15 microsatellite instability-high tumors. The microsatellite instabilityhigh phenotype tended to occur more frequently in low-grade tumors (P ¼ 0.053), but did not correlate with clinical stage. Totally, 38% of cases also displayed loss of heterozygosity at D17S250; this loss of heterozygosity was associated with high clinical stage (P ¼ 0.097). Our results indicate that both microsatellite and loss of heterozygosity at D17S250 are involved in the development of ovarian endometrioid carcinoma.

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“…Improved survival has been noted in 11/89 women whose endometrial cancers did not express MLH1 (103) .…”

Section: Stage and Gradementioning

confidence: 99%

The contribution of DNA mismatch repair gene defects to the burden of gynecological cancer

DRAKE,

CAMPBELL,

PORTEOUS

et al. 2003

Int J Gynecol Cancer

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Prognostic Relevance of hMLH1, hMSH2, and BAX Protein Expression in Endometrial Carcinoma

Cited by 16 publications

References 38 publications

Loss of hMLH1 expression is associated with less aggressive clinicopathological features in sporadic endometrioid endometrial adenocarcinoma

Loss of hMLH1 expression is associated with less aggressive clinicopathological features in sporadic endometrioid endometrial adenocarcinoma

Microsatellite instability and expression of hMLH1 and hMSH2 proteins in ovarian endometrioid cancer

The contribution of DNA mismatch repair gene defects to the burden of gynecological cancer

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