2022
DOI: 10.3389/fonc.2022.866293
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Prognostic Relevance of Estrogen Receptor Status in Circulating Tumor Cells in Breast Cancer Patients Treated With Endocrine Therapy

Abstract: Recently, female breast cancer (BC) has surpassed lung cancer to occupy the first place of the most commonly diagnosed cancer. The unsatisfactory prognosis of endocrine therapy for breast cancer might be attributed to the discordance in estrogen receptor (ER) status between primary tumors and corresponding metastases, as well as temporal and spatial receptor status heterogeneity at point-in-time between biopsy and treatment. The purpose of this study was to evaluate the prognostic and predictive value of ER st… Show more

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Cited by 4 publications
(4 citation statements)
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References 57 publications
(58 reference statements)
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“…Healthy donors had few epithelial cells in 2.0 mL blood (≈0–2 CTCs, mean [0.2 CTCs], median [0 CTCs]; ≥ 1 CTCs, 14.3%), similar to other trials. [ 28,31,39 ] The number of CTCs (≈0–350 CTCs, median [2 CTCs], mean [28 CTCs]) and CTC detection rate (≥1 CTCs, 65.0%) at baseline are superior to other reports by CellSearch in 7.5 mL blood (Nanou et al., ≈0–312 CTCs, median [0 CTCs]; Iwatsuki et al., ≈0–353 CTCs, mean [18 CTCs]; Cohen et al., ≥ 3 CTCs, 26.0%). [ 29,30,35 ] Thus, sensitivity (65.0%) and specificity (85.7%) of CTC detection by TUMORFISHER are competitive in mCRC, which could be mainly attributed to the smaller size and larger number of EpCAM recognition peptides on TUMORFISHER than anti‐EpCAM antibodies on CellSearch .…”
Section: Discussionmentioning
confidence: 93%
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“…Healthy donors had few epithelial cells in 2.0 mL blood (≈0–2 CTCs, mean [0.2 CTCs], median [0 CTCs]; ≥ 1 CTCs, 14.3%), similar to other trials. [ 28,31,39 ] The number of CTCs (≈0–350 CTCs, median [2 CTCs], mean [28 CTCs]) and CTC detection rate (≥1 CTCs, 65.0%) at baseline are superior to other reports by CellSearch in 7.5 mL blood (Nanou et al., ≈0–312 CTCs, median [0 CTCs]; Iwatsuki et al., ≈0–353 CTCs, mean [18 CTCs]; Cohen et al., ≥ 3 CTCs, 26.0%). [ 29,30,35 ] Thus, sensitivity (65.0%) and specificity (85.7%) of CTC detection by TUMORFISHER are competitive in mCRC, which could be mainly attributed to the smaller size and larger number of EpCAM recognition peptides on TUMORFISHER than anti‐EpCAM antibodies on CellSearch .…”
Section: Discussionmentioning
confidence: 93%
“…Healthy donors had few epithelial cells in 2.0 mL blood (≈0-2 CTCs, mean [0.2 CTCs], median [0 CTCs]; ≥ 1 CTCs, 14.3%), similar to other trials. [28,31,39] The number of CTCs (≈0-350 CTCs, median ). [29,30,35] Thus, sensitivity (65.0%) and specificity (85.7%) of CTC detection by TUMORFISHER are competitive in mCRC, which could be mainly attributed to the smaller size and larger number of EpCAM recognition peptides on TUMORFISHER than anti-EpCAM antibodies on CellSearch.…”
Section: Discussionmentioning
confidence: 99%
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“…Detectable in primary lung adenocarcinomas, ER is used for predicting hormonal therapy responses in breast cancer despite its limited prognostic significance [38]. Progesterone receptor (PR)…”
Section: Estrogen Receptor (Er)mentioning
confidence: 99%