Prognostic predictors and outcomes in patients with abnormal myocardial perfusion imaging and angiographically insignificant coronary artery disease

Alqaisi, Fadi; Al-Badarin, Firas; Jaffery, Zehra; Tzogias, Leonidas; Dawod, Muath; Jacobsen, Gordon; Ananthasubramaniam, Karthik

doi:10.1007/bf03007356

Cited by 23 publications

(7 citation statements)

References 27 publications

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“…In addition, even in the patients with abnormal MPI, but normal angiography, the careful evaluation about cardiovascular disease in these subgroup of patients may 27 . Recently, Delcour et al, assessed 48 patients who had ischemia on MPI and normal coronary angiography with a mean 7.4 years follow-up in which 15 subjects (31%) had cardiovascular events.…”

Section: Discussionmentioning

confidence: 99%

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Myocardial perfusion imaging using a technetium-99m Sestamibi in asymptomatic and low risk for coronary artery disease patients with diagnosed systemic lupus erythematosus

et al. 2010

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Section: Discussionmentioning

confidence: 99%

“…helpful. In the literature, a number of investigations focused on this issue[27][28][29][30][31][32][33][34][35][36] . Alqaisi et al compared the outcomes in 125 patients with abnormal MPI and insignificant CAD with 136 patients as a control group over a 24-month follow-up.…”

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confidence: 99%

Myocardial perfusion imaging using a technetium-99m Sestamibi in asymptomatic and low risk for coronary artery disease patients with diagnosed systemic lupus erythematosus

et al. 2010

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“…Interestingly, the presence of an abnormal perfusion study in the absence of angiographically significant CAD is associated with a worse outcome, suggesting a possible dissociation between anatomy and physiology rather than a false positive [31]. SPECT imaging is more predictive of cardiac events than clinical, exercise testing and cardiac catheterization alone [32].…”

Section: Prognosismentioning

confidence: 99%

Radionuclide cardiac stress testing

Badheka

Hendel

2011

Current Opinion in Cardiology

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“…Coronary artery disease (CAD) is still the most common cause of death worldwide. [ 1 2 3 ] Beside diagnostic applications, the prognostic value of myocardial perfusion imaging (MPI) has been well established. [ 4 5 ] Normal MPI by semiquantitative visual interpretation is associated with low risk of future cardiac events (<1%) in different studies.…”

Section: Introductionmentioning

confidence: 99%

Assessment of prognostic value of semiquantitative parameters on gated single photon emission computed tomography myocardial perfusion scintigraphy in a large middle eastern population

et al. 2015

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Objectives:Coronary artery disease is the leading cause of mortality worldwide. The goal of this study is to determine the prognostic value of semiquantitative parameters of electrocardiogram-gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) in a large Middle Eastern (Iranian) population.Materials and Methods:This study was a prospective study including all patients referred to our center for myocardial perfusion scan. The patients were followed annually up to 24 months and their survival information was collected.Results:From 1148 patients, 473 (41.2%) men and 675 (58.8%) women, 40.6% had normal MPI, 13.3% near normal and 46.1% abnormal MPI. After follow-up of 929 patients, 97.4% of patients were alive, and 2.6% succumbed to cardiac deaths. Abnormal ejection fraction was related with cardiac events (P = 0.001), but neither transient ischemic dilation (TID) (P = 0.09) nor lung/heart ratio (P = 0.92) showed such relationship. Association between summed difference score (SDS) and soft cardiac events (P < 0.001) was significant. Summed motion score (SMS) and summed thickening score (STS) showed a significant relation with hard cardiac events, including myocardial infarction and cardiac death (P < 0.001 and P = 0.001, respectively). Totally, risk of all cardiac events was significantly higher in abnormal MPI group than normal group (P < 0.001, 0.02, and 0.025, respectively). No significant relationship was found between TID and total cardiac events (P = 0.478).Conclusion:Semiquantitative variables derived from gated SPECT MPI have independent prognostic value. Rate of total cardiac events is higher in patients with higher summed stress score and SDS. Total and hard cardiac events are higher in upper scores of functional parameters (SMS and STS). Total cardiac events are higher in patients with lower left ventricular ejection fraction.

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Prognostic predictors and outcomes in patients with abnormal myocardial perfusion imaging and angiographically insignificant coronary artery disease

Abstract: Patients with abnormal SMPI and ICAD have a 13% event rate of MACE over a two-year follow up. CKD seems a very important marker of a higher risk subgroup amongst such patients.

Cited by 23 publications

References 27 publications

Myocardial perfusion imaging using a technetium-99m Sestamibi in asymptomatic and low risk for coronary artery disease patients with diagnosed systemic lupus erythematosus

Myocardial perfusion imaging using a technetium-99m Sestamibi in asymptomatic and low risk for coronary artery disease patients with diagnosed systemic lupus erythematosus

Radionuclide cardiac stress testing

Assessment of prognostic value of semiquantitative parameters on gated single photon emission computed tomography myocardial perfusion scintigraphy in a large middle eastern population

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