Prognostic Nutritional Index Predicts Early Mortality in Diffuse Large B-cell Lymphoma

Öztürk, Erman; Elibol, Tayfun; Kılıçaslan, Emrah; Kabayuka, Beyza; Özünal, Işıl Erdoğan

doi:10.4274/mmj.galenos.2022.87422

Cited by 3 publications

(4 citation statements)

References 27 publications

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“…[ 25 ] Thus, serum ALB was used to construct multiple prognostic models to evaluate the outcome of patients with DLBCL. [ 23 , 26 – 28 ]…”

Section: Discussionmentioning

confidence: 99%

“…[25] Thus, serum ALB was used to construct multiple prognostic models to evaluate the outcome of patients with DLBCL. [23,[26][27][28] Increased plasma FIB is commonly discovered in infectious diseases, rheumatic diseases, diabetes, thrombotic disorders and malignant tumors. In an in vitro assay, it was identified that FIB played an important role in promoting lymphoma cell adhesion, [29] revealing that FIB might accelerate the progress of lymphoma and influence the prognosis for lymphoma patients.…”

Section: Patient Characteristicsmentioning

confidence: 99%

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Prognostic value of lactate dehydrogenase to absolute lymphocyte count ratio and albumin to fibrinogen ratio in diffuse large B-cell lymphoma

Shi,

Wu,

Deng

et al. 2024

Medicine

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With the continuous improvement of treatment strategy, the prognostic value of international prognostic index (IPI) alone is limited for diffuse large B-cell lymphoma (DLBCL). Our study aims to explore the effect of lactate dehydrogenase (LDH)to absolute lymphocyte count (ALC) ratio (LAR) and albumin to fibrinogen ratio (AFR) on the prognosis of patients with DLBCL. The venous blood LDH, ALC, albumin and fibrinogen within 1 week before the first chemotherapy in 74 DLBCL patients were collected to calculate the LAR and AFR values. The impact of LAR and AFR on the progression-free survival (PFS) of patients with DLBCL was studied by the survival analysis. The area under the receiver operating characteristic curve (AUC) and concordance index (C-index) were used to analyze the predictive efficiency of each model for the PFS of DLBCL patients. Cox univariate analysis suggested that elevated LAR (P < .001) and decreased AFR (P < .001) were risk factors for PFS in DLBCL patients. Multivariate analysis revealed that LAR (P < .001) and AFR (P = .004) were 2 independent prognostic parameters. The AUC values of IPI, AFR + IPI, LAR + IPI and AFR + LAR + IPI to predict the PFS of DLBCL patients were 0.806 (95%CI 0.707–0.905, P < .001), 0.839 (95%CI 0.747–0.932, P < .001), 0.851 (95%CI 0.764–0.938, P < .001), and 0.869 (95%CI 0.787–0.952, P < .001), respectively. The C-index values of above 4 models were 0.802 (95%CI 0.629–0.975, P < .001), 0.842 (95% CI 0.735–0.949, P < .001), 0.846 (95%CI 0.716–0.976, P < .001), and 0.864 (95%CI 0.781–0.941, P < .001), respectively. The results suggest that both LAR and AFR are independent prognostic factors for PFS in DLBCL patients. Furthermore, their combination with IPI has better predictive efficiency for the prognosis of DLBCL patients.

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“…[ 25 ] Thus, serum ALB was used to construct multiple prognostic models to evaluate the outcome of patients with DLBCL. [ 23 , 26 – 28 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Patient Characteristicsmentioning

confidence: 99%

Prognostic value of lactate dehydrogenase to absolute lymphocyte count ratio and albumin to fibrinogen ratio in diffuse large B-cell lymphoma

Shi,

Wu,

Deng

et al. 2024

Medicine

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“…Although various serological tests, anthropometric measurements, and screening tools are used for this purpose, there has yet to be a consensus on a method. It has been reported in the literature that the prognostic nutritional index [PNI=10 x serum albumin (g/dl) + 0.005 x total lymphocyte count (mm 3 )] is associated with poor prognosis in various clinical conditions and malignancies and is a significant predictor of mortality [ 6 , 7 ]. It has been stated that PNI can be a comprehensive marker in evaluating the nutritional status of patients undergoing surgery and is also helpful in detecting postoperative delirium in geriatric hip fracture patients [ 8 ].…”

Section: Highlight Key Pointsmentioning

confidence: 99%

Predictive value of prognostic nutritional index on postoperative intensive care requirement and mortality in geriatric hip fracture patients

Arslan

2024

North Clin Istanbul

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OBJECTIVE The incidence of postoperative morbidity and mortality in hip fracture patients is high and is associated with nutritional deficiencies. This study investigated the predictive value of preoperative prognostic nutritional index (PNI) on postoperative intensive care unit (ICU) requirement and mortality in geriatric hip fracture patients. METHODS Geriatric (≥65 years old) hip fracture patients who underwent surgery between January 2021 and September 2023 were evaluated retrospectively. Patients were classified according to the unit followed in the postoperative period (service group and ICU group) and 28-day mortality (mortality group and survivor group). The predictive value of PNI for ICU requirement and mortality and the factors affecting ICU requirement and mortality were investigated. RESULTS The study included two hundred twenty-two patients, and 66.2% (n=147) were women. In the postoperative period, 47.7% (n=106) of the patients were followed in the ICU and 52.3% (n=116) in the inpatient service. The 28-day mortality of the patients was 6.8% (n=15). PNI was found to be significantly lower in patients followed in the ICU (group ICU) than in those followed in the service (group S) and in patients who died (group mortality) compared to those who lived (group survivor) (p<0.001 and p=0.029, respectively). In multivariate regression analysis, high American Society of Anesthesiologists (ASA) status and low PNI were determined to be independent risk factors for ICU requirement. Acute Physiology and Chronic Health Assessment II score was an independent predictor of mortality. In ROC curve analysis, the cut-off value of PNI in predicting mortality was 32.5, and the area under the curve was 0.660 (95% CI, 0.516–0.803). CONCLUSION In geriatric hip fracture patients, preoperative PNI value can be used, like ASA status, in determining postoperative ICU requirements. Nutritional deficiencies are associated with adverse postoperative outcomes in this patient group, and low PNI values (<32.5) help predict in-hospital mortality.

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“…Afterward, PNI gradually became a new predictor of the prognosis of many diseases. For example, low PNI contributes to high adverse events in preeclampsia [ 20 ]; it also can predict early mortality in diffuse large B-cell lymphoma [ 21 ]. Recent research even documented that PNI can be used to guide the clinician in predicting the 30-day mortality of patients diagnosed with delirium [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical Significance of the Prognostic Nutritional Index in Predicting Delirium among Critically Ill Patients: A Retrospective Cohort Study

Xu,

Zhong

2024

Critical Care Research and Practice

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Delirium is a serious and complex problem facing critically ill patients. This retrospective study aimed to explore the association between prognostic nutrition index (PNI) and delirium in critically ill patients in the intensive care unit (ICU). This study was based on the Medical Information Mart Intensive Care IV (MIMIC IV) database. Patients over 18 years of age were enrolled. Univariate and multivariate logistic regression analyses were performed to explore the association between PNI and delirium. Tendency analysis, subgroups analysis, and restricted cubic spline (RCS) were selected to further certify the association. The receiver operating characteristic curve (ROC) was adopted to assess the predictability of PNI to delirium. Propensity score matching (PSM) was used to reduce the interference of confounders. A total of 3,105 patients participated in this study. As the grade of malnutrition increases, the incidence of delirium increases in all models. The odds ratios (OR) of delirium in the fully adjusted model were 1.00 (reference), 1.04 (0.80, 1.36), 1.53 (1.17, 1.99), and 1.93 (1.44, 2.59). Strong U-shaped curves were found with RCS analysis between delirium and PNI in the subgroups of patients over 60 years of age and patients with chronic obstructive pulmonary disease (COPD). After PSM, the ORs of delirium were 1.44 (1.16, 1.79) and 1.53 (1.22, 1.93), respectively, in the univariate and multivariate logistic regression models. PNI is negatively associated with the prevalence of delirium in critically ill adults in the ICU. PNI is an independent risk factor for the incidence of delirium in adults in the ICU.

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Prognostic Nutritional Index Predicts Early Mortality in Diffuse Large B-cell Lymphoma

Cited by 3 publications

References 27 publications

Prognostic value of lactate dehydrogenase to absolute lymphocyte count ratio and albumin to fibrinogen ratio in diffuse large B-cell lymphoma

Prognostic value of lactate dehydrogenase to absolute lymphocyte count ratio and albumin to fibrinogen ratio in diffuse large B-cell lymphoma

Predictive value of prognostic nutritional index on postoperative intensive care requirement and mortality in geriatric hip fracture patients

Clinical Significance of the Prognostic Nutritional Index in Predicting Delirium among Critically Ill Patients: A Retrospective Cohort Study

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