Prognostic nomograms and risk-stratifying systems for predicting survival in patients with resected pT2-4aN0M0 esophageal carcinoma

Dou, Xiao-Meng; Zhang, Na; Fang, Yanyan; Zhang, Bo-Han; Liao, Jie-Jing; Cai, Jing-Sheng; Li, Jinbo

doi:10.21037/jtd-20-3393

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…Finally, a nomogram was established. As is known that nomogram is a widely used and efficient tool for predicting prognosis in malignancies such as breast cancer [ 18 ], gastric cancer [ 19 ], esophageal carcinoma [ 20 ], and lung cancer [ 21 , 22 , 23 ]. The C-index of our nomogram was little pale (only 0.65).…”

Section: Discussionmentioning

confidence: 99%

Occult Non-Small Cell Lung Cancer: An Underappreciated Disease

Cai

Yang

Wang

2022

JCM

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Background: The number of researches on occult non-small cell lung cancer (NSCLC) is modest. Herein, we defined the clinicopathological features, prognosis and survival outcome of this underappreciated tumor, with purpose of obtaining a clearer picture on this disease. Methods: The entire cohort was categorized into two groups (occult NSCLC and other NSCLC) and further into five groups (occult, T1, T2, T3 and T4). A least absolute shrinkage and selection operator (LASSO) penalized Cox regression model was performed to identify the prognostic indicators. A nomogram and a risk-classifying system were formulated. Kaplan–Meier with Log-rank method was carried out to compare overall survival (OS) and cancer specific survival (CSS) differences between groups. Results: 59,046 eligible NSCLC cases (occult NSCLC: 1158 cases; other NSCLC: 57,888 cases) were included. Occult NSCLC accounted for 2.0% of the included cases. Multivariate analysis revealed that age, sex, tumor location, histology, grade and surgery were prognostic factors for OS. The corresponding prognostic nomogram classified occult NSCLC patients into low-risk and high-risk group, and its performance was acceptable. Survival curves demonstrated that occult NSCLC patients exhibited worse survivals than other NSCLC. In further analyses, the survival of low-risk occult NSCLC and stage T3 NSCLC were comparable, and the high-risk occult NSCLC patients still owned the worst survival rate. Conclusions: Occult NSCLC was an aggressive tumor with poor prognosis, and surgery was the preferred treatment. More attention should be paid to this overlooked disease due to no evidence of tumor imaging.

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