Prognostic nomogram for previously untreated patients with esophageal squamous cell carcinoma after esophagectomy followed by adjuvant chemotherapy

Duan, Jingjing; Deng, Ting; Ying, Guoguang; Huang, Dingzhi; Zhang, Haiyang; Zhou, Lyu; Bai, Ming; Liu, Hongli; Yang, Huimin; Qu, Yanjun; Wang, Xia; Ba, Yi

doi:10.1093/jjco/hyv206

Cited by 22 publications

(23 citation statements)

References 44 publications

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“…Additionally, eight studies reported about the prognostic significance of tumor length for DFS in EC patients. [5,7,10,14,17,19,20,22] Our pooled result indicated that long tumor was also significantly associated with poor DFS (HR = 1.29, 95% CI = 1.11–1.50, P < 0.01, Fig. 3).…”

Section: Meta-analysismentioning

confidence: 69%

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Prognostic significance of tumor length in patients with esophageal cancer undergoing radical resection

Yang¹,

Liu

Li³

et al. 2019

Medicine

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Background: The prognostic significance of tumor length in esophageal cancer (EC) remains controversial. Hence, we conducted a meta-analysis to quantitatively assess the prognostic significance of tumor length in EC patients. Method: A systematic literature search was conducted in the PubMed, EMBASE, and Web of Science. Hazard ratios (HRs) with their 95% confidence intervals (CIs) were used to assess the prognostic significance of tumor length for overall survival (OS), and disease-free survival (DFS) in EC patients. Results: A total of 21 articles with 22 eligible studies involving 9271 patients were included in this meta-analysis. The results of our pooling analyses demonstrated that tumor length was an independent prognostic parameter for OS (HR = 1.38, 95% CI: 1.24–1.54, P < .01) and DFS (HR = 1.29, 95% CI: 1.11–1.50, P < .01) in EC patients. Moreover, our subgroup analysis and sensitivity analysis showed that the pooled HRs assessing the prognostic significance of tumor length did not significantly fluctuated, suggesting our pooling analyses were stable and reliable. Conclusion: The results of this meta-analysis demonstrated that long tumor is an independent risk of poor OS and DFS in EC patients, suggesting that it may provide additional prognostic information and thus contribute to a better stratification of EC patients, especially for those with no lymph node metastasis. However, more well-designed prospective clinical studies with large sample size are needed to strength our conclusion due to several limitations in this meta-analysis.

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Section: Meta-analysismentioning

confidence: 69%

“…Of these 22, 21 studies investigated the relationship of tumor length to OS of EC patients, [4–16,18–23,30] and 8 studies reported about DFS. [5,7,10,14,17,19,20,22] The characteristics of the included studies were summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Prognostic significance of tumor length in patients with esophageal cancer undergoing radical resection

Yang¹,

Liu

Li³

et al. 2019

Medicine

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“…However, its long‐term results in esophageal squamous cell carcinoma (ESCC) patients have not been fully characterized. Squamous cell carcinoma is the most common esophageal cancer in China and has a different prevalence, biological pattern, and prognosis from that of esophageal adenocarcinoma …”

Section: Introductionmentioning

confidence: 99%

“…Squamous cell carcinoma is the most common esophageal cancer in China and has a different prevalence, biological pattern, and prognosis from that of esophageal adenocarcinoma. 1,4,5 In this retrospective study, we analyzed the outcomes of 530 MIE Ivor Lewis procedures in ESCC patients at a single institution performed by one qualified surgeon. Our goals were to evaluate perioperative outcomes, quality of life (QOL), survival, prognosis factors and the influence of adjuvant therapies.…”

mentioning

confidence: 99%

Retracted: Long‐term outcomes of 530 esophageal squamous cell carcinoma patients with minimally invasive Ivor Lewis esophagectomy

2018

Journal of Surgical Oncology

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“…Lin SH and colleagues [13] used gender, tumor grade, standardized uptake value of the primary tumor by positron emission tomography (PET) after chemoradiation, baseline T status (by endoscopic sonography) and esophagogastroduodenoscopy biopsy results after chemoradiation as predictive factors in a nomogram for predicting pathologic complete response in esophageal cancer patients receiving chemoradiation without surgery. Duan J et al [14] reported that two nomograms, based on tumor length, gender, N stage, T stage and chemotherapy cycles, were created for predicting 1-, 2-, 3-year disease-free survival and 1-, 2-, 3-year overall survival in esophageal squamous cell carcinoma patients who underwent radical esophagectomy and adjuvant chemotherapy. Suzuki A et al [15] reported that two nomograms were established to predict 3-, 5-year disease-free survival and 3-, 5-year overall survival in patients with esophageal and gastroesophageal junction cancers receiving definitive chemoradiotherapy according to five factors, including stage, grade, histology, initial standardized uptake value of PET and clinical complete response.…”

Section: Discussionmentioning

confidence: 99%

Nomograms for predicting risk of locoregional recurrence and distant metastases for esophageal cancer patients after radical esophagectomy

Zhang

Chen

et al. 2018

BMC Cancer

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BackgroundThe aim of this study was to develop nomograms for predicting the risk of locoregional recurrence or distant metastasis in esophageal cancer patients who were treated with esophagectomy and regional lymphadenectomy.MethodsThe clinicopathologic data of 408 esophageal cancer patients after esophagectomy and regional lymphadenectomy were analyzed in this study. Univariate and multivariate COX regression analyses were used to test the association between the clinicopathologic data and the risk of locoregional recurrence or distant metastasis. The nomograms were built from the COX regression model.ResultsUnivariate analyses revealed that tumor length, tumor width, T-staging and perineural invasion(PNI) were significantly associated with locoregional recurrence, and that tumor length, tumor width, differentiation, T-staging, N-staging, lymph vascular space invasion(LVSI), PNI and adjuvant chemotherapy were significantly associated with distant metastasis. Multivariate analyses revealed that tumor length, tumor width and T-staging were predictors of risk of locoregional recurrence, and that differentiation, N-staging, LVSI and PNI were predictors of risk of distant metastasis. Two nomograms were constructed for a visual explanation of these two COX regression models. The bias-corrected curve showed no significant departure from the ideal curve in these two nomograms.ConclusionsTwo nomograms were developed and validated to predict the risk of locoregional recurrence and distant metastasis in esophageal cancer patients after radical esophagectomy. The calculation outcome will help oncologists to choose adjuvant treatment regimens.

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Prognostic nomogram for previously untreated patients with esophageal squamous cell carcinoma after esophagectomy followed by adjuvant chemotherapy

Abstract: The prognostic nomogram provided individualized risk estimate of survival in patients after esophagectomy followed by adjuvant chemotherapy.

Cited by 22 publications

References 44 publications

Prognostic significance of tumor length in patients with esophageal cancer undergoing radical resection

Prognostic significance of tumor length in patients with esophageal cancer undergoing radical resection

Retracted: Long‐term outcomes of 530 esophageal squamous cell carcinoma patients with minimally invasive Ivor Lewis esophagectomy

Nomograms for predicting risk of locoregional recurrence and distant metastases for esophageal cancer patients after radical esophagectomy

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