Prognostic nomogram for predicting 5-year overall survival in Chinese patients with high-grade osteosarcoma

Abstract

This study aimed to construct a widely accepted prognostic nomogram in Chinese high-grade osteosarcoma (HOS) patients aged ≤ 30 years to provide insight into predicting 5-year overall survival (OS). Data from 503 consecutive HOS patients at our centre between 12/2012 and 05/2019 were retrospectively collected. Eighty-four clinical features and routine laboratory haematological and biochemical testing indicators of each patient at the time of diagnosis were collected. A prognostic nomogram model for predicting OS was constructed based on the Cox proportional hazards model. The performance was assessed by the concordance index (C-index), receiver operating characteristic curve and calibration curve. The utility was evaluated by decision curve analysis. The 5-year OS was 52.1% and 2.6% for the nonmetastatic and metastatic patients, respectively. The nomogram included nine important variables based on a multivariate analysis: tumour stage, surgical type, metastasis, preoperative neoadjuvant chemotherapy cycle, postoperative metastasis time, mean corpuscular volume, tumour-specific growth factor, gamma-glutamyl transferase and creatinine. The calibration curve showed that the nomogram was able to predict 5-year OS accurately. The C-index of the nomogram for OS prediction was 0.795 (range, 0.703–0.887). Moreover, the decision curve analysis curve also demonstrated the clinical benefit of this model. The nomogram provides an individualized risk estimate of the 5-year OS in patients with HOS aged ≤ 30 years in a Chinese population-based cohort.

Ru Nanoparticles Supported on Mesoporous Al‐SBA‐15 Catalysts for Highly Selective Hydrogenation of Furfural to Furfuryl Alcohol

“…The RuS3 catalyst exhibited characteristic peaks at 2θ=38.37°, 42.22° and 44.01° corresponding to the (100), (002), and (101) planes, respectively. The diffraction peak matched that of metallic Ru (JCPDS 06‐0663) [38,40,41] …”

Lung and bone metastases patterns in osteosarcoma: Chemotherapy improves overall survival

“…[ 15 ] Before 2010, there was no detailed information on the metastases of all malignant tumors in the SEER database. [ 16 ] We studied patients with OS between 2010 and 2019, The histological types of OS were limited to 9180/3, 9181/3, 9182/3, 9183/3, 9184/3, 9185/3, 9186/3, 9187/3, 9192/3, 9193/3, and 9194/3 according to the International Classification of Diseases for Oncology-3 (ICD-O-3); 9180/3, 9181/3, 9182/3, 9183/3, 9184/3, 9185/3, 9186/3, 9186/3, 9193/3, 9193/3, and 9194/3 represent OS NOS, chondroblastic OS, fibroblastic OS, telangiectatic OS, OS in Paget disease of bone, small cell OS, central OS, intraosseous well-differentiated OS, parosteal OS, periosteal OS and high-grade surface OS, respectively. [ 17 ] The exclusion criteria were as follows: patients with OS from the SEER database outside of January 1, 2010, to December 31, 2019; OS was not the primary disease of the patients; and blank options for OS patients.…”

Lung metastases pattern in limb osteosarcoma: A population-based study from 2010 to 2018

“…The histological types of OS were limited to 9180/3, 9181/3, 9182/3, 9183/3, 9184/3, 9185/3, 9186/3, 9187/3, 9192/3, 9193/3, and 9194/3 according to the International Classification of Diseases for Oncology-3 (ICD-O-3). [ 8 ] 9180/3, 9181/3, 9182/3, 9183/3, 9184/3, 9185/3, 9186/3, 9187/3, 9192/3, 9193/3, and 9194/3 represented osteosarcoma NOS, chondroblastic osteosarcoma, fibroblastic osteosarcoma, telangiectatic osteosarcoma, osteosarcoma in Paget disease of bone, small cell osteosarcoma, central osteosarcoma, intraosseous well differentiated osteosarcoma, parosteal osteosarcoma, periosteal osteosarcoma and high grade surface osteosarcoma respectively. Limb OS was limited to c40.0, c40.1, c40.2, c40.3, c40.8, c40.9, c49.1, and c49.2 according to the primary situation.…”