Prognostic Nomogram for Overall Survival in Extranodal Natural Killer/T-Cell Lymphoma Patients

Li, Kaiguo; Wang, Ruyue; Huang, Shan; Pan, Xin-Bin; Chen, Hongmin; Jiang, Wei; Wu, Chin‐Chen; Zhu, Xiaodong; Liang, Shi-Xiong; Qu, Song

doi:10.1016/j.clml.2018.08.011

Cited by 14 publications

(14 citation statements)

References 20 publications

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“…Another possible explanation for this inconsistence was that their study with a small sample size (n = 100) may be underpowered to examine the prognostic value of CAR in ENKTL. Moreover, in keeping with previous findings in ENKTL, 9,16 the AGR, a frequently reported prognostic index which reflected the nature of both immunity and inflammation in diffuse large B-cell lymphoma, 33,34 also maintained its independent prognostic value in ENKTL.…”

Section: Discussionsupporting

confidence: 89%

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High C-Reactive Protein to Albumin Ratio Predicts Inferior Clinical Outcomes in Extranodal Natural Killer T-Cell Lymphoma

Tao

Song

et al. 2020

Dose-Response

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Objective: The prognostic value of C-reactive protein to albumin ratio (CAR) has been identified in several cancers but not in extranodal natural killer T-cell lymphoma (ENKTL) as yet. We aimed to evaluate the prognostic value of CAR in ENKTL. Methods: A retrospective study with 246 patients with ENKTL was performed to determine the prognostic value of pretreatment CAR and examine the prognostic performance of CAR incorporating with International Prognostic Index (IPI) or natural killer/T-cell lymphoma prognostic index (NKPI) by nomogram. Results: The Cox regression analyses showed that high CAR (>0.3) independently predicted unfavorable progression-free survival (PFS, P = .011) and overall survival (OS, P = .012). In the stratification analysis, the CAR was able to separate patients into different prognoses regarding both OS and PFS in Ann Arbor stage I+II as well as III+IV, IPI score 0 to 1, and NKPI score 1 to 2 subgroups (all P < .05). Additionally, the predictive accuracy of the IPI-based nomogram incorporating CAR, albumin to globulin ratio (AGR), and IPI for OS and PFS appeared to be lower than the NKPI-based nomogram incorporating CAR, age, AGR, extranodal site, and NKPI. Conclusion: Pretreatment CAR is a simple and easily accessible parameter for independently predicting OS and PFS in patients with ENKTL.

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Section: Discussionsupporting

confidence: 89%

“…1 With this regard, some researchers have found that the predictive value of these models may be further improved by other laboratory parameters (fasting blood glucose, C-reactive protein [CRP], platelet count, albumin, soluble interleukin 2 receptor, and absolute lymphocyte count). 2,7 -12…”

Section: Introductionmentioning

confidence: 99%

High C-Reactive Protein to Albumin Ratio Predicts Inferior Clinical Outcomes in Extranodal Natural Killer T-Cell Lymphoma

Tao

Song

et al. 2020

Dose-Response

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“…Our nomogram uses clinically significant variables that are associated with outcomes, and the final prognostic model consists of 4 clinical variables in a multivariate Cox proportional hazards model. Similar to the studies on ENKL, 4,16,17 our nomogram has provided a favorable level of predictive accuracy compared with the IPI and KPI. The C-index for the nomogram was 0.87, whereas the IPI and KPI were 0.57 and 0.59, respectively.…”

Section: Discussionsupporting

confidence: 74%

“…However, neither an optimal treatment strategy nor a valuable prognostic index has been identified. 5,[8][9][10][11][12][13][14][15][16] Several studies have identified a few important prognostic variables and indices that predict outcomes. However, these prognostic variables and indices are rarely suitable for early stage patients who have received high-dose RT, and some of them remain controversial.…”

Section: Introductionmentioning

confidence: 99%

“…However, these prognostic variables and indices are rarely suitable for early stage patients who have received high-dose RT, and some of them remain controversial. 14,[16][17][18][19][20] On the basis of big data, Yang et al 4,5 have shown an important prognostic nomogram for ENKL, which suggested a better risk stratification compared with the International Prognostic Index (IPI) and the Korean Prognostic Index (KPI). Although this model was not on the basis of data of patients who received highdose RT, which was significantly associated with better OS and progression-free survival (PFS) in their follow-up study, 21 Yang et al have provided a concise and effective format for prognostic nomogram models that can be easily understood by patients and physicians.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic Nomogram for Overall Survival in Early Stage Extranodal Natural Killer/T Cell Lymphoma Treated With High-Dose Radiotherapy

Wang

et al. 2020

Clinical Lymphoma Myeloma and Leukemia

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The prognostic system for early stage extranodal natural killer/T-cell lymphoma, nasal-type (ENKL) treated with high-dose radiotherapy (RT) remains unclear. We developed a nomogram including 4 variables in 81 early ENKL patients treated with high-dose RT. This nomogram could predict 5-year overall survival accurately, which provides a meaningful risk estimate for early ENKL. Background: The aim of this study was to develop a prognostic nomogram for early stage extranodal natural killer/ T-cell lymphoma, nasal type (ENKL) treated with high-dose radiotherapy (RT). Patients and Methods: A total of 81 patients at 2 cancer centers with stage I to IIE ENKL who received chemotherapy (CT) and high-dose RT were retrospectively analyzed. The development of the nomogram was on the basis of the Cox proportional hazards model. We implemented the concordance index (C-index) and performed a calibration curve to determine its predictive and discriminatory capacity and compared our nomogram with the International Prognostic Index (IPI) and the Korean Prognostic Index (KPI). Results: The nomogram included 4 important variables and used a multivariate analysis: lactate dehydrogenase, primary tumor invasion, tumor response, and CT regimen. The 5-year OS rate and progression-free survival were 64.7% and 57.5%, respectively for the entire group. The C-index of the nomogram for overall survival (OS) prediction was 0.87, and it was superior to the predictive power of the IPI and KPI. The calibration curve showed that the nomogram accurately predicted the 5-year OS. Conclusion: The proposed nomogram could provide an individualized risk estimate of the OS for early stage ENKL treated with CT and high-dose RT.

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The prognostic value of controlling nutritional status (CONUT) score–based nomogram on extranodal natural killer/T cell lymphoma patients

et al. 2023

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Prognostic Nomogram for Overall Survival in Extranodal Natural Killer/T-Cell Lymphoma Patients

Abstract: Our proposed nomogram based on Eastern Cooperative Oncology Group performance status, Ann Arbor stage, albumin-to-globulin ratio, and platelet count provides an individualized risk estimate of OS in patients with ENKTL.

Cited by 14 publications

References 20 publications

High C-Reactive Protein to Albumin Ratio Predicts Inferior Clinical Outcomes in Extranodal Natural Killer T-Cell Lymphoma

High C-Reactive Protein to Albumin Ratio Predicts Inferior Clinical Outcomes in Extranodal Natural Killer T-Cell Lymphoma

Prognostic Nomogram for Overall Survival in Early Stage Extranodal Natural Killer/T Cell Lymphoma Treated With High-Dose Radiotherapy

The prognostic value of controlling nutritional status (CONUT) score–based nomogram on extranodal natural killer/T cell lymphoma patients

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