Prognostic Meaning of Chromosome Aberrations in Acute Lymphocytic Leukemia and Acute Nonlymphocytic Leukemia Patients of the BFM Study Group

High hyperdiploid childhood acute lymphoblastic leukemia

“…Subsequently, Kaneko et al (1981) described six children who all achieved complete remission (CR) after induction treatment comprised only of vincristine and prednisolone and who remained in CR for several years. During the following years, numerous studies confirmed the favorable outcome of this cytogenetic subgroup (Kaneko et al, 1982;Williams et al, 1982;Harbott et al, 1987;Heinonen et al, 1988;Michael et al, 1988;Prigogina et al, 1988;Bloomfield et al, 1989;Fenaux et al, 1989;Secker-Walker et al, 1989), and by the end of the 1980s, the favorable prognosis of high hyperdiploid ALL had become widely recognized.…”

“…Subsequent studies during the 1980s showed that the high hyperdiploid cases were characterized by the expression of the ''common'' (CD10) ALL antigen (Third International Workshop on Chromosomes in Leukemia, 1981a,b;Kaneko et al, 1982;Williams et al, 1982;Heerema et al, 1985;Smets et al, 1985;Harbott et al, 1987;Heinonen et al, 1988;Michael et al, 1988;Pui et al, 1988b;Fenaux et al, 1989;Secker-Walker et al, 1989;Uckun et al, 1989). As more surface markers were identified and used in immunophenotypic analyses, it gradually became apparent that high hyperdiploid lymphoblasts typically are positive for TdT, HLA-DR, CD10, CD19, CD22, CD24, CD34, and CD66c and negative for CD13, CD33, CD45, CD65, cIg, and sIg Behm et al, 1992; Groupe Français de Cytogé né tique Hé matologique, 1993;Lavabre-Bertrand et al, 1994;Raimondi et al, 1996;Hrušá k et al, 1998;Hruîsá k and PorwitMacDonald, 2002).…”