Prognostic indices predictive of short-term disease-free survival of breast carcinoma patients receiving primary surgical treatment in Sri Lanka

Wijesinghe, H. D.; Thuvarakan, P.; Samarasekera, Anandi; Lokuhetty, M. D. S.

doi:10.4103/ijpm.ijpm_321_17

Cited by 2 publications

(3 citation statements)

References 24 publications

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“…However, the study observed no relationship between Bcl-2 immuno-expression and molecular subtype of breast cancer. A similar observation of discordant relationship in between molecular subtype of luminal A and Bcl-2 immuno-expression by Wijesinghe et al [13] and Bayoudh et al [14] The study of Hwang et al [11] observed the Bcl-2 immunoexpression in 51.2% cases and luminal A subtype held its association with significant p-value (p < 0.01).…”

Section: Short Review Results and Discussionsupporting

confidence: 57%

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Bcl-2 Immunoexpression in Invasive Ductal Carcinoma and Its Evaluative Correlation with Molecular Sub-Types and BR-Grade and TNM Stage

Pandey¹,

Bhake²

2023

Breast Cancer Updates

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Invasive Ductal carcinoma is the most common histological type of breast cancer. It constitutes about 80 percent of all breast cancer diagnoses. The molecular pathogenesis of breast cancer involves multiple gene types. Bcl-2 is one of them. Bcl-2, is an anti-apoptotic protein which is up regulated by oestrogen in breast cancer patients. The immunoexpression of Bcl-2 detection is being carried out by immunohistochemical methods as described in many published studies. Bcl-2 as is known acts through transcriptional induction in pathogenesis of breast cancer. The present chapter describes the role of Bcl-2 in pathogenesis, significance and its relationship with BR Grade and TNM stage. The present chapter specifically describes its observation of Bcl-2 immunoexpression and relationship with molecular subtypes of breast carcinoma.

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Section: Short Review Results and Discussionsupporting

confidence: 57%

“…The search for publications over this topic originating in India was found to be marginal which correlated clinicopathological variables, molecular subtypes of breast cancer and BR-grades [12,13].…”

Section: Flowchart -Evasion Of Cell Deathmentioning

confidence: 99%

Bcl-2 Immunoexpression in Invasive Ductal Carcinoma and Its Evaluative Correlation with Molecular Sub-Types and BR-Grade and TNM Stage

Pandey¹,

Bhake²

2023

Breast Cancer Updates

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show abstract

“…The search for publications over this topic originating in India was found to be marginal rather, the correlative studies with clinicopathological variable, molecular subtypes of breast cancer and BR-grades are negligible [11].…”

Section: Introductionmentioning

confidence: 99%

A Study of Bcl-2 Immuno-expression in Invasive Ductal Carcinoma of Breast and it’s Correlation with Molecular Sub-types

Pandey

Bhake

Vagha

2021

JPRI

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Background: The incidence of Breast cancers has overtaken the cervical cancers amongst Indian females. Invasive Ductal carcinoma is reported to be the most common form of breast cancer. Bcl-2 has been studied extensively as a common factor in the pathogenesis of solid tumours including breast cancer. Bcl-2 is an anti-apoptotic protein normally expressed in mammary tissue and is up-regulated by oestrogen in breast cancer through direct consequence of transcriptional induction. The present study attempts to look into Bcl-2 immunoexpression as a key parameter for predicting the treatment outcomes and recurrence of Invasive Ductal Carcinoma. Methodology : This will be an observational study conducted in Department of Pathology, JNMC, Wardha. The study will include clinicopathological detailing of 50 mastectomy specimens of Invasive ductal carcinoma, detailed sectioning of tumour tissues, histopathological BR-grading and molecular subtyping using Bcl-2 immunohistochemistry. Expected Results: A significant correlation is expected between Bcl-2 expression and treatment outcomes and recurrence of Invasive Ductal Carcinoma. Conclusion: The conclusion will be drawn based on careful analysis of the results.

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Prognostic indices predictive of short-term disease-free survival of breast carcinoma patients receiving primary surgical treatment in Sri Lanka

Cited by 2 publications

References 24 publications

Bcl-2 Immunoexpression in Invasive Ductal Carcinoma and Its Evaluative Correlation with Molecular Sub-Types and BR-Grade and TNM Stage

Bcl-2 Immunoexpression in Invasive Ductal Carcinoma and Its Evaluative Correlation with Molecular Sub-Types and BR-Grade and TNM Stage

A Study of Bcl-2 Immuno-expression in Invasive Ductal Carcinoma of Breast and it’s Correlation with Molecular Sub-types

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