Prognostic indicators in venous ulcers

Phillips, Tania J.; Machado, Fidelis; Trout, Richard; Porter, John M.; Olin, Jeffrey W.; Falanga, Vincent

doi:10.1067/mjd.2000.107496

Cited by 180 publications

(136 citation statements)

References 19 publications

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“…It is expected that the incidence and prevalence of chronic wounds will rise due to an increasingly elderly population with compromised cardiovascular status (Phillips et al, 2000). Therefore, a greater sense of urgency is developing for increasing the effectiveness of our clinical approach to chronic wounds.…”

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confidence: 99%

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Fibroblasts from chronic wounds show altered TGF‐β‐signaling and decreased TGF‐β Type II Receptor expression

Kim

Park

et al. 2003

Journal Cellular Physiology

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Chronic wounds are characterized by failure to heal in a defined time frame. However, the pathogenic steps leading from the etiological factors to failure to heal are unknown. Recently, increasing evidence suggests that resident cells in chronic wounds display a number of critical abnormalities, including senescence and unresponsiveness to the stimulatory action of transforming growth factor-b1 (TGF-b1). In this study, we have determined some of the mechanisms that might be responsible for unresponsiveness to TGF-b1. Using Northern analysis and affinity labeling, we show that venous ulcer fibroblasts have decreased TGF-b Type II receptor expression. This finding is not the result of genetic mutation, as shown by experiments with Type II receptor satellite instability. Decreased Type II receptor expression was accompanied by failure of ulcer fibroblasts to phosphorylate Smad 2, Smad 3, and p42/44 mitogen activating protein kinase (MAPK), and was associated with a slower proliferative rate in response to TGF-b1. We conclude that venous ulcer fibroblasts show decreased Type II receptor expression and display abnormalities in the downstream signaling pathway involving MAPK and the early Smad pathway. These findings suggest ways to address and treat the abnormal cellular phenotype of cells in chronic wounds.

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confidence: 99%

“…However, in spite of this substantial progress in how chronic wounds are treated, there remains a great need for accelerating their healing and for preventing recurrences. Also, many chronic wounds heal extremely slowly or simply do not heal in spite of all appropriate therapies (Phillips et al, 2000;Falanga, 2001).…”

mentioning

confidence: 99%

Fibroblasts from chronic wounds show altered TGF‐β‐signaling and decreased TGF‐β Type II Receptor expression

Kim

Park

et al. 2003

Journal Cellular Physiology

Self Cite

167

128

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“…But there is substantial evidence to indicate our lacunae in the treatment of chronic wounds particularly of more than 1 year duration. 5 Stem cell therapy has been extensively studied to fill in this void. With the inherent difficulties involved in using embryonic stem cells, both from the technical and regulatory standpoints, adult autologous bone marrow-derived stem cells become an attractive alternative.…”

Section: Discussionmentioning

confidence: 99%

Autologous Bone Marrow Aspirate Therapy in Wound Healing

Chittoria

Nandhagopal

Mohapatra

et al. 2016

Advances in Wound Care

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“…Die wesentlichen prognostischen Indikatoren für die Abheilung VU sind die Größe und Bestandsdauer [4]. So sinkt die Abheilungsrate bei einer Ausdehnung >5 cm² von 72 % auf 40 % und bei einer Bestandsdauer von >2 Jahren auf 29 %.…”

Section: Epidemiologie Und Sozioökonomische Datenunclassified

Das venöse Ulcus cruris

Böhler

2016

Wien Med Wochenschr

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Zusammenfassung Erkrankungen der Beinvenen, die zu einer permanenten venösen Drucksteigerung füh-ren, sind bei weitem die häufigste Ursache für Substanzdefekte an den unteren Extremitäten. Mit einer Prävalenz von 1 %, die bei Personen über 80 Jahren auf 4 % ansteigt, und dem meist chronischen Krankheitsverlauf verschlingt die Therapie des venösen Ulcus 1 % des gesamten Gesundheitsbudgets westlicher Industriestaaten. Erst eine detaillierte Abklärung der vorliegenden venösen Funktionsstörungen ermöglicht eine differenzierte Therapie, die, sofern möglich, die operative Sanierung venöser Refluxe ebenso wie die Lokaltherapie der Wunde umfasst. Für therapieresistente Ulcera hat sich die tangentiale Abtragung der Wunde mit anschließender Spalthautdeckung bewährt. So kann vor allem bei lang bestehenden und großflä-chigen Defekten eine Abheilung erzielt werden. Die Kompressionstherapie stellt eine Basismaßnahme in der Therapie und der Rezidivprophylaxe venöser Ulcera dar. Aus differentialdiagnostischer Sicht müssen vor allem Pathologien der arteriellen Strombahn sowie entzündliche Gefäßerkrankungen und Neoplasien bedacht werden.Schlüsselwörter Chronisch venöse Insuffizienz · Venöses Ulcus · Beinulcus Venous ulcerSummary Venous disorders causing a permanent increase in venous pressure are by far the most frequent reason for ulcers of the lower extremity. With Ao.Univ.-Prof. Dr.med.univ. K. Böhler ( )

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Prognostic indicators in venous ulcers

Cited by 180 publications

References 19 publications

Fibroblasts from chronic wounds show altered TGF‐β‐signaling and decreased TGF‐β Type II Receptor expression

Fibroblasts from chronic wounds show altered TGF‐β‐signaling and decreased TGF‐β Type II Receptor expression

Autologous Bone Marrow Aspirate Therapy in Wound Healing

Das venöse Ulcus cruris

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