Prognostic Indicators for Successful Low-intensity Extracorporeal Shock Wave Therapy Treatment of Erectile Dysfunction

Adeldaeim, Hussein M.; Abouyoussif, Tamer; Gebaly, Omar El; Assem, Akram; Wahab, Moataza M. Abdel; Rashad, Hazem; Sakr, Mostafa A.; Zahran, Abdelrahman

doi:10.1016/j.urology.2020.12.019

Cited by 13 publications

(15 citation statements)

References 21 publications

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“…In our study, the statistically significant increase in the IIEF-EF scores 6 months post-treatment (p = .001) as compared to the baseline scores in each patient group is consistent with the literature indicating that Li-SWT applications are effective in ED treatment (Adeldaeim et al, 2021;Raheem et al, 2020).…”

Section: Ta B L E 3 Comparison Of the Mean Iief-ef Score Increase Between Groups Based On Ed Gradessupporting

confidence: 91%

“…Even though the application of regenerative therapies in humans is limited, the use of Li‐SWT and PRP is well known (Campbell et al., 2020). Although the mechanism of the treatment is unclear and a standardised treatment protocol is lacking, Li‐SWT is known to be safe and effective in the treatment of ED (Adeldaeim et al., 2021; Campbell et al., 2019). Moreover, it is a recommended treatment option in the EAU guidelines for ED and in patients with mild vasculogenic ED or poor responses to PDE5i (EAU Guidelines, 2020).…”

Section: Discussionmentioning

confidence: 99%

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Comparison of the efficacy of low‐intensity shock wave therapy and its combination with platelet‐rich plasma in patients with erectile dysfunction

Geyik

2021

Andrologia

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We aimed to compare the efficacy of low-intensity shock wave therapy (Li-SWT) alone and its combination with platelet-rich plasma (PRP) in the treatment of patients with erectile dysfunction (ED). Between January 2015 and October 2020, patients who did not benefit from the use of phosphodiesterase type 5 inhibitors (PDE5i; 5 mg/day) for at least 3 months and underwent Li-SWT or Li-SWT with PRP were How to cite this article: Geyik, S. (2021). Comparison of the efficacy of low-intensity shock wave therapy and its combination with platelet-rich plasma in patients with erectile dysfunction. Andrologia, 53, e14197.

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Section: Ta B L E 3 Comparison Of the Mean Iief-ef Score Increase Between Groups Based On Ed Gradessupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Comparison of the efficacy of low‐intensity shock wave therapy and its combination with platelet‐rich plasma in patients with erectile dysfunction

Geyik

2021

Andrologia

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“…High-energy shock waves have been used for the disintegration of urinary tract stones since 1980. Subsequently, several studies have reported the application of LESW to human tissue for the regeneration or repair of bones [ 24 ], muscles [ 25 ], and other soft tissues [ 26 , 27 ]. The advantages of shock waves are their noninvasiveness, ease of handling by clinicians, and the short-term treatment course.…”

Section: Discussionmentioning

confidence: 99%

Extracorporeal Shock Wave Enhances the Cisplatin Efficacy by Improving Tissue Infiltration and Cellular Uptake in an Upper Urinary Tract Cancer Animal and Human-Derived Organoid Model

Luo

Liu

Chang

et al. 2021

Cancers

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Upper urinary tract urothelial carcinoma (UTUC) is a relatively rare cancer with a poor prognosis if diagnosed at an advanced stage. Although cisplatin-based chemotherapy is a common treatment strategy, it has a limited response rate. Shock wave lithotripsy is a common treatment for upper urinary tract stones. Low-energy shock waves (LESWs) temporarily increase tissue permeability and enhance drug penetration to the targeted tissue. However, no study has investigated the efficacy of the combination of shock wave lithotripsy and chemotherapy in UTUC. Hence, in this study, we aimed to identify the potential application of the combination of LESW and chemotherapy in UTUC. We evaluated the synergistic effects of LESW and cisplatin in vitro, in vivo, and in patient-derived organoid (PDO) models. Compared with cisplatin alone, the combination treatment caused more significant tumour suppression in vitro and in animal models, without increased toxicity. Histological examination showed that compared with animals treated with cisplatin alone, those who received the combination treatment showed more deteriorated cell arrangement and cell oedema. Moreover, LESW improved the cytotoxicity of cisplatin in the preclinical PDO model of UTUC. Thus, LESW combined with cisplatin is a potential new antitumour strategy for improving the treatment response in locally advanced UTUC.

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“…Though the study design is missing randomization and blinding, the long follow up and volume of patients, stratified by severity of ED, is worth noting. 34 To better identify the ideal LiSWT treatment, there have been a few studies that have compared various treatment protocols. Ramasamy et al performed a RCT comparing patients receiving 3,600 shocks over 1 week (n = 40) vs 2 weeks (n = 40) (Electromagnetic, MoreNova, DirexGroup, Israel, energy density of 0.09 mJ/mm 2 and frequency of 1Hz).…”

Section: Low-intensity Shock Wave Therapy (Liswt)mentioning

confidence: 99%

“…Though the study design is missing randomization and blinding, the long follow up and volume of patients, stratified by severity of ED, is worth noting. 34 …”

Section: Low-intensity Shock Wave Therapy (Liswt)mentioning

confidence: 99%

Restorative Therapies for Erectile Dysfunction: Position Statement From the Sexual Medicine Society of North America (SMSNA)

et al. 2021

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Introduction: Current non-invasive treatments for erectile dysfunction (ED) include oral medications, intracavernosal injections, and vacuum-assisted devices. Though these therapies work well for many, a subset of patients have contraindications or are unsatisfied with these options. Restorative therapies for ED are a new frontier of treatments focused on regenerating diseased tissue and providing a potential "cure" for ED. Aim: The aim of this position statement is to examine existing clinical trial data for restorative therapies and identify elements that require further research before widespread adoption. Methods: A literature review was performed to identify all clinical trials performed with regenerative therapy for ED. This includes treatments such as stem cell therapy (SCT), platelet rich plasma (PRP), and restorative related technologies like low-intensity shockwave therapy (LiSWT). Main Outcome Measures: Most clinical trials in restorative therapies were assessed for safety, feasibility, or efficacy. This included recording adverse events, changes in sexual function and erectile function questionnaires, and diagnostics measures. Results: To date there is an absence of robust clinical data supporting the efficacy of restorative therapies regarding ED, though technologies such as LiSWT have established relative safety. Conclusions: Restorative therapies are a promising technology that represents a new frontier of treatment geared towards reversing disease pathology rather than just treating symptoms. However, current published clinical studies are limited. Future work needs to be adequately powered, multi-center, randomized, sham/ placebo-controlled trials in well-characterized patient populations to ensure safety and demonstrate efficacy. Until these studies are done, restorative therapies should be reserved for clinical trials and not offered in routine clinical practice. Liu JL, Chu KY, Gabrielson AT, et al. Restorative Therapies for Erectile Dysfunction: Position Statement From the Sexual Medicine Society of North America (SMSNA).

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Prognostic Indicators for Successful Low-intensity Extracorporeal Shock Wave Therapy Treatment of Erectile Dysfunction

Cited by 13 publications

References 21 publications

Comparison of the efficacy of low‐intensity shock wave therapy and its combination with platelet‐rich plasma in patients with erectile dysfunction

Comparison of the efficacy of low‐intensity shock wave therapy and its combination with platelet‐rich plasma in patients with erectile dysfunction

Extracorporeal Shock Wave Enhances the Cisplatin Efficacy by Improving Tissue Infiltration and Cellular Uptake in an Upper Urinary Tract Cancer Animal and Human-Derived Organoid Model

Restorative Therapies for Erectile Dysfunction: Position Statement From the Sexual Medicine Society of North America (SMSNA)

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