Prognostic indicators based on inflammatory and nutritional factors after pancreaticoduodenectomy for pancreatic cancer

Abstract

The mGPS, PNI, and NLR were effective predictive indicators of postoperative complications. The PLR was the most useful prognostic indicator for pancreatic cancer patients after pancreaticoduodenectomy.

The influence of nutritional status on the incidence of postoperative complications in patients following distal pancreatectomy

“…Watanabe et al [18] analysed inflammatory and nutritional parameters using the modified Glasgow Prognostic Score (mGPS), PNI, NLR, and PLR in 46 patients after pancreaticoduodenectomy for pancreatic cancer. In patients with PNI < 40, significantly lower haemoglobin levels and a higher number of intra-abdominal bleedings were noted.…”

“…In multivariate analysis, only the PLR was an independent prognostic indicator. There are some other publications in the literature regarding the influence of immunological status on the incidence of postoperative complications [18].…”

“…Information regarding deterioration of nutritional status, body weight before disease and current body weight, loss of body weight and food intake since the onset of disease, comorbidities (arterial hypertension, ischaemic heart disease, diabetes mellitus), and smok- [16,17]. The immunological parameters, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and lymphocyte/monocyte ratio (LMR), were calculated [18]. Onodera's nutritional prognostic index (PNI) was calculated based on the serum albumin concentration and total lymphocyte count in the peripheral blood using the following formula: 10 × level of albumin (g/dl) + 0.005 × total lymphocyte count (/mm 3 ) [19].…”

A serological scoring system to predict lymph node metastasis in patients with hepatocellular carcinoma

“…Recently, a microRNA markers model in predicting LNM in HCC patients has been reported, but this model cannot be used routinely by clinicians. 10 As serological markers such as the neutrophil/lymphocyte rate (NLR) and platelet/lymphocyte rate (PLR) have gradually become commonly used in clinical studies in the diagnosis and prognosis of various cancers , [11][12][13][14][15][16][17][18] it would be interesting to study the association between serological markers and LNM, which has not been reported in HCC patients. Noninvasive methods that predict LNM in HCC patients provide important information to clinicians to decide on the most appropriate choice of treatment for HCC patients.…”

Influencia del estado nutricional e inflamatorio preoperatorio sobre las complicaciones tras cirugía curativa del cáncer colorrectal

“…En el CCR, se correlaciona de forma significativa con la supervivencia, de un modo inversamente proporcional a su valor, de tal modo que cuanto más elevado se muestra este cociente, peor es la SG, SLE y la supervivencia específica por cáncer[235,[241][242][243][244][245].Al igual que se apreció con el NLR, el valor de PLR es muy superior en pacientes con CCR comparado con pacientes sanos o con pólipos no malignizados. Por lo que se ha propuesto como un método complementario de seguimiento en pacientes con pólipos ya que un aumento de su valor también puede hacer sospechar, de forma barata y sencilla, la presencia de CCR[234].Al contrario que el resto de scores, su relación con la aparición de complicaciones y con la mortalidad postoperatoria apenas ha sido estudiada, y cuando lo ha sido, no ha mostrado una significación estadística relevante como para ser considerada una variable capaz de predecir la morbimortalidad postoperatoria[246].1.10.7.-ALBÚMINA Y PREALBÚMINA.Tanto la albúmina como la prealbúmina se han utilizado extensamente en la valoración nutricional de pacientes. Y aunque no reflejan de forma muy fidedigna el grado de desnutrición proteica, sus niveles sí se modifican de forma importante ante situaciones inflamatorias, lo que les hace unos marcadores fiables, rápidos y sencillos a la hora de valorar el estado nutricional e inflamatorio de los pacientes oncológicos.…”